Results 221 to 230 of about 145,951 (305)

Virtual memory CD8+ T cells restrain the viral reservoir in HIV-1-infected patients with antiretroviral therapy through derepressing KIR-mediated inhibition. [PDF]

Cell Mol Immunol, 2020
Jin JH, Huang HH, Zhou MJ, Li J, Hu W, Huang L, Xu Z, Tu B, Yang G, Shi M, Jiao YM, Fan X, Song JW, Zhang JY, Zhang C, Wang FS.   +15 more
europepmc   +1 more source

Spatial behavior of socially isolated wild pigs (Sus scrofa) following sounder removal via trapping

Pest Management Science, EarlyView.
Following partial sounder removal, socially isolated wild pigs maintained site fidelity near traps, highlighting post‐control behavioral tendencies that are relevant to pest management and disease mitigation. Abstract BACKGROUND The rapid expansion of wild pig (Sus scrofa) populations across North America, coupled with increased concern over disease ...
Sebastian Gomez‐Maldonado, Matthew T McDonough, Jonathon J Valente, Mark D Smith, Stephen S. Ditchkoff   +4 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Promoter targeted small RNAs: stabilising viral reservoirs

Microbiology Australia, 2014
openaire   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet‐Based Cell Mechanoporation Platform

Small, EarlyView.
This study introduces a microfluidic droplet mechanoporation system for the engineering of primary human T cells. The platform enables efficient, scalable, and robust delivery of mRNA for CAR T cell production and CRISPR‐Cas9 ribonucleoproteins for genome editing, while maintaining high cell viability.
You‐Jeong Kim, Sungwon Bang, Aram J. Chung   +2 more
wiley   +1 more source

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

Capture of isoflurane from anaesthetised dogs and cats following methadone, medetomidine and ketamine administration

Veterinary Record, EarlyView.
Abstract Background Volatile anaesthetic agents contribute to climate change, and reducing this impact is a commendable ambition. We evaluated the efficiency of a veterinary capture device for isoflurane (VET‐can/VET‐dock, SageTech Veterinary) in anaesthetised cats and dogs.
Florence Hillen, David Yates, Kate White
wiley   +1 more source

Unraveling the impact of dog‐friendly spaces on urban–wildland pumas and other wildlife

Wildlife Biology, EarlyView.
As the most widespread large carnivore on the planet, domestic dogs Canis lupus familiaris can pose a major threat to wildlife, even within protected areas (PAs). Growing human presence in PAs, coupled with increasing pet dog ownership underscores the urgency to understand the influence of dogs on wildlife activity and health.
Alys Granados, Zara McDonald, Katie McPherson, David Stoner   +3 more
wiley   +1 more source

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. [PDF]

Nat Microbiol, 2019
Ahn M, Anderson DE, Zhang Q, Tan CW, Lim BL, Luko K, Wen M, Chia WN, Mani S, Wang LC, Ng JHJ, Sobota RM, Dutertre CA, Ginhoux F, Shi ZL, Irving AT, Wang LF.   +16 more
europepmc   +1 more source