Results 21 to 30 of about 24,194,770 (306)

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E, Woodward, Martin J, Rooks, David, Rooks, D. J., Smith, Darren L, McCarthy, Alan J, McDonald, James E; id_orcid, Woodward, Martin J., Darren L. Smith, Smith, Darren, Rooks, David J, David J. Rooks, Martin J. Woodward, McCarthy, Alan, McCarthy, A. J., Smith, D. L., Heather E. Allison, McDonald, James, Allison, Heather, James E. McDonald, Woodward, Martin, Alan J. McCarthy, McDonald, J. E., Allison, H. E.   +23 more
core   +1 more source

A stochastic analysis of three viral sequences. [PDF]

Molecular Biology and Evolution, 1992
This paper analyzes the nucleotide sequences of three viruses: Kunjin, west Nile, and yellow fever. Each virus has one long open reading frame of greater than 10,200 nucleotides that codes for four structural and seven nonstructural genes. The Kunjin and west Nile viruses are the most closely related pair, when assessed on the basis of matches between ...
openaire   +2 more sources

The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: A longitudinal analysis [PDF]

, 2009
Background/Aims: Although there have been a few reports regarding the effect of basal core promoter (BCP) double mutations (A1762T and G1764A) on hepatitis B viral loads, the association remains uncertain.
Fang, Kong-Xiong, Yang, Jin-Ye, Harrison, Tim J., Wang, Xue-Yan, Wei, SC, Harrison, TJ, Wang, XY, Fang, KX, Chen, QY, Fang, ZL, Dong, Bai-Qing, Wei, Shao-Chao, Chen, Qin-Yan, Sabin, Caroline A, Yang, JY, Sabin, CA, Dong, BQ, Fang, Zhong-Liao   +17 more
core   +1 more source

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]

, 2010
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H., G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +7 more
core   +1 more source

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

Genome Biology, 2023
Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated ...
Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox   +29 more
doaj   +1 more source

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]

, 1991
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schlicht, Hans-Jürgen, Ruppert, Thomas, Margarita Del Val, Hans-Jürgen Schlicht, Thomas Ruppert, Matthias J. Reddehase, Ulrich H. Koszinowski   +9 more
core   +1 more source

Viral metagenomics updated the prevalence of human papillomavirus types in anogenital warts

Emerging Microbes and Infections, 2019
To investigate the composition of human papillomavirus (HPV) types in anogenital warts (AGWs), viral nucleic acid in 110 AGWs, pooled into 11 specimen pools, were subjected to viral metagenomic analysis.
Hui Xu, Yu Ling, Yuan Xi, Hong Ma, Hao Wang, Hui-Min Hu, Qi Liu, Yu-Mei Li, Xu-Tao Deng, Shi-Xing Yang, Eric Delwart, Wen Zhang   +11 more
doaj   +1 more source

HCMV Envelope Glycoprotein Diversity Demystified

Frontiers in Microbiology, 2019
Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals.
Mathilde Foglierini, Mathilde Foglierini, Jessica Marcandalli, Laurent Perez   +3 more
doaj   +1 more source

Analysis of viral diversity for vaccine target discovery

BMC Medical Genomics, 2017
Background Viral vaccine target discovery requires understanding the diversity of both the virus and the human immune system. The readily available and rapidly growing pool of viral sequence data in the public domain enable the identification and ...
Asif M. Khan, Yongli Hu, Olivo Miotto, Natascha M. Thevasagayam, Rashmi Sukumaran, Hadia Syahirah Abd Raman, Vladimir Brusic, Tin Wee Tan, J. Thomas August   +8 more
doaj   +1 more source