Results 81 to 90 of about 24,194,770 (306)

Viral proteins acquired from a host converge to simplified domain architectures. [PDF]

PLoS Computational Biology, 2012
The infection cycle of viruses creates many opportunities for the exchange of genetic material with the host. Many viruses integrate their sequences into the genome of their host for replication.
Nadav Rappoport, Michal Linial
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Bioinformatics analysis of large-scale viral sequences [PDF]

Virulence, 2013
Due to a significant decrease in the cost of DNA sequencing, the number of sequences submitted to the public databases has dramatically increased in recent years. Efficient analysis of these data sets may lead to a significant understanding of the nature of pathogens such as bacteria, viruses, parasites, etc.
openaire   +2 more sources

Bioinformatics and Microarray-Based Technologies to Viral Genome Sequence Analysis [PDF]

, 2019
Identification of microbial pathogen is an important event which lead to diagnosis, treatment, and control of infections produce by them. The high-throughput technology like microarray and new-generation sequencing machine are able to generate huge amount of nucleotide sequences of viral and bacterial genome of both known and unknown pathogens.
Pokhriyal, Mayank, Ratta, Barkha, Yadav, Brijesh S.   +2 more
openaire   +1 more source

Rapidly obtaining genome sequence of Severe Fever with Thrombocytopenia Syndrome virus directly from clinical serum specimen using long amplicon based nanopore sequencing workflow.

PLoS ONE
Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging viral infectious disease discovered in 2009 with a high fatality rate and continuing to pose a public threat for many countries.
Tingting Tian, Yanhan Wen, Liping Gao, Tiezhu Liu, Xiaoxia Huang, Chuan Li, Shanshan Du, Hao Li, Meijun Guo, Jiandong Li, Shiwen Wang, Dexin Li, Aqian Li, Mifang Liang   +13 more
doaj   +1 more source

The ViReflow pipeline enables user friendly large scale viral consensus genome reconstruction

Scientific Reports, 2022
Throughout the COVID-19 pandemic, massive sequencing and data sharing efforts enabled the real-time surveillance of novel SARS-CoV-2 strains throughout the world, the results of which provided public health officials with actionable information to ...
Niema Moshiri, Kathleen M. Fisch, Amanda Birmingham, Peter DeHoff, Gene W. Yeo, Kristen Jepsen, Louise C. Laurent, Rob Knight   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Viral Diagnostics in Plants Using Next Generation Sequencing: Computational Analysis in Practice [PDF]

Frontiers in Plant Science, 2017
Viruses cause significant yield and quality losses in a wide variety of cultivated crops. Hence, the detection and identification of viruses is a crucial facet of successful crop production and of great significance in terms of world food security. Whilst the adoption of molecular techniques such as RT-PCR has increased the speed and accuracy of viral ...
Susan Jones, Amanda Baizan-Edge, Stuart MacFarlane, Lesley Torrance, Lesley Torrance   +4 more
openaire   +4 more sources

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source