Results 31 to 40 of about 246,650 (312)

Structural basis for the coevolution of a viral RNA–protein complex [PDF]

Nature Structural & Molecular Biology, 2007
The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA ...
Robert H. Singer, Jeffrey A. Chao, Steven C. Almo, Yury Patskovsky   +3 more
openaire   +3 more sources

Picornaviruses: A View from 3A

Viruses, 2021
Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important human and animal diseases. The genome encodes a single large polyprotein that is
Terry Jackson, Graham J. Belsham
doaj   +1 more source

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +1 more source

Sindbis viral structural protein cytotoxicity on human neuroblastoma cells [PDF]

Pediatric Surgery International, 2020
Abstract Purpose Oncolytic viral therapy for neuroblastoma (NB) cells with Sindbis virus (SINV) is a promising strategy for treating high-risk NB. Here, we evaluated the possibility of using SINV structural proteins as therapeutic agents for NB since UV-inactivated SINV could induce cytopathogenic effects.
Eriko Y. Saito, Kengo Saito, Tomoro Hishiki, Ayako Takenouchi, Takeshi Saito, Yoshiharu Sato, Keita Terui, Tadashi Matsunaga, Hiroshi Shirasawa, Hideo Yoshida   +9 more
openaire   +3 more sources

Structure and Neutralization of Viral Fusion Proteins

, 2023
Emerging infectious diseases remain persistent threats that are challenging to predict. Humanity has faced many terrible pandemics and will face more, but to pinpoint the specific time and place of an outbreak, the type of pathogen, and the consequences is effectively impossible.
openaire   +2 more sources

Structural and Functional Properties of Viral Membrane Proteins [PDF]

, 2018
Viruses have developed a large variety of transmembrane proteins to carry out their infectious cycles. Some of these proteins are simply anchored to membrane via transmembrane helices. Others, however, adopt more interesting structures to perform tasks such as mediating membrane fusion and forming ion-permeating channels.
Ying Dong, James J. Chou, Bo OuYang
openaire   +1 more source

Deciphering the Role of Bovine Viral Diarrhea Virus Non-Structural NS4B Protein in Viral Pathogenesis [PDF]

Veterinary Sciences, 2020
Bovine viral diarrhea virus (BVDV) is a (+) ssRNA virus that belongs to the family Flaviviridae. BVDV is a significant animal pathogen causing substantial economic losses to the cattle industry worldwide through respiratory and gastrointestinal infections and abortion or birth of persistently infected calves.
Shahbaz Bashir, Andrey Kossarev, Violeta Cascon Martin, Jan Paeshuyse   +3 more
openaire   +4 more sources

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Biomolecules, 2018
Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral
Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung   +8 more
doaj   +1 more source

Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis

Viruses, 2023
The porcine reproductive and respiratory syndrome virus (PRRSV) causes economic losses in the swine industry worldwide. However, current vaccines cannot provide effective protection against PRRSV, and PRRSV-specific treatments for infected herds are ...
Zhenbang Zhu, Yuqian Xu, Lulu Chen, Meng Zhang, Xiangdong Li   +4 more
doaj   +1 more source

A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin [PDF]

mBio, 2016
ABSTRACT Latent infections by viruses usually involve minimizing viral protein expression so that the host immune system cannot recognize the infected cell through the viral peptides presented on its cell surface. Herpes simplex virus (HSV), for example, is thought to express noncoding RNAs such as latency-associated transcripts (
Raja, Priya, Lee, Jennifer, Pesola, Jean, Coen, Donald, Knipe, David, Pan, Dongli   +5 more
openaire   +5 more sources