Results 71 to 80 of about 1,666,541 (346)

Level of viral load suppression in Rwinkwavu District Hospital: A cross-sectional study

Journal of Interventional Epidemiology and Public Health
Introduction: The Rwinkwavu district hospital faces challenges in understanding and improving the human immunodeficiency virus viral load suppression rates among patients receiving antiretroviral therapy.
Metuschelah Habimana, Rachel Niyogushimwa, Vedaste Ndahindwa, Theoneste Ntakirutimana   +3 more
doaj   +1 more source

Intermittent Bictegravir/Emtricitabine/Tenofovir Alafenamide Treatment Maintains High Level of Viral Suppression in Virally Suppressed People Living with HIV

Journal of Personalized Medicine, 2023
In this observational study, we aimed to evaluate whether bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) administered 5 or 4 days a week is able to maintain viral suppression in people living with HIV (PLHIV). We enrolled 85 patients who initiated intermittent B/F/TAF between 28 November 2018 and 30 July 2020: median (IQR) age 52 years (46 ...
Baptiste Sellem, Basma Abdi, Minh Lê, Roland Tubiana, Marc-Antoine Valantin, Sophie Seang, Luminita Schneider, Antoine Fayçal, Gilles Peytavin, Cathia Soulié, Anne-Geneviève Marcelin, Christine Katlama, Valérie Pourcher, Romain Palich   +13 more
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Short-Cycle Therapy in Adolescents after Continuous Therapy with Established Viral Suppression: The Impact on Viral Load Suppression [PDF]

AIDS Research and Human Retroviruses, 2009
This was a proof-of-principle study to evaluate the impact of short cycle therapy (SCT; 4 days on/3 days off) in adolescents and young adults with good viral suppression on a protease inhibitor-based antiretroviral regimen. Subjects were recruited by the Adolescent Trials Network for HIV/AIDS Interventions and the Pediatric AIDS Clinical Trials Group ...
Bret J, Rudy, John, Sleasman, Bill, Kapogiannis, Craig M, Wilson, James, Bethel, Leslie, Serchuck, Sushma, Ahmad, Coleen K, Cunningham   +7 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Accuracy of Provider Predictions of Viral Suppression Among Adolescents and Young Adults With HIV in an HIV Clinical Program

Journal of the International Association of Providers of AIDS Care
Background Providers caring for adolescents and young adults with HIV (AYA-HIV) mostly base their adherence counseling during clinical encounters on clinical judgment and expectations of patients’ medication adherence.
Johannes Thrul PhD, Hasiya Yusuf MD, MPH, Janardan Devkota MS, MPH, Jill Owczarzak PhD, MA, Elise Tirza Ohene-Kyei MD, MPH, Kelly Gebo MD, MPH, Allison Agwu MD, ScM, FAAP, FIDSA   +6 more
doaj   +1 more source

The Association of Clinical Follow-Up Intervals in HIV-Infected Persons with Viral Suppression on Subsequent Viral Suppression [PDF]

AIDS Patient Care and STDs, 2013
The recommendation for the frequency for routine clinical monitoring of persons with well-controlled HIV infection is based on evidence that relies on observed rather than intended follow-up intervals. We sought to determine if the scheduled follow-up interval is associated with subsequent virologic failure.
April, Buscher, Michael, Mugavero, Andrew O, Westfall, Jeanne, Keruly, Richard, Moore, Mari-Lynn, Drainoni, Meg, Sullivan, Tracey E, Wilson, Allan, Rodriguez, Lisa, Metsch, Lytt, Gardner, Gary, Marks, Faye, Malitz, Thomas P, Giordano   +13 more
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Antiretroviral Adherence Level Necessary for HIV Viral Suppression using Real-World Data

Journal of Acquired Immune Deficiency Syndromes, 2019
Background: A benchmark of near-perfect adherence (≥95%) to antiretroviral therapy (ART) is often cited as necessary for HIV viral suppression. However, given newer, more effective ART medications the threshold for viral suppression might be lower.
Kathy K. Byrd, John G. Hou, R. Hazen, H. Kirkham, Sumihiro Suzuki, P. Clay, T. Bush, Nasima M. Camp, P. Weidle, A. Delpino   +9 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source