Results 61 to 70 of about 1,274,523 (300)

Avian Bornaviruses Escape Recognition by the Innate Immune System [PDF]

, 2010
Like other pathogens that readily persist in animal hosts, members of the Bornaviridae family have evolved effective mechanisms to evade the innate immune response.
Kothlow, Sonja, Ackermann, Andreas, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Kaspers, Bernd, Antje Reuter, Andreas Ackermann, Sonja Kothlow, Rinder, Monika, Monika Rinder, Reuter, Antje, Bernd Kaspers, Staeheli, Ackermann, Reuter, Kothlow, Kaspers, Rinder   +18 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Unsuppressed viral load after intensive adherence counselling in rural eastern Uganda; a case of Kamuli district, Uganda

BMC Public Health, 2021
Background The East Central (EC) region of Uganda has the least viral suppression rate despite having a relatively low prevalence of human immunodeficiency virus (HIV).
Geoffrey Ndikabona, John Bosco Alege, Nicholas Sebuliba Kirirabwa, Derrick Kimuli   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Therapy of Hepatitis B — Viral Suppression or Eradication? [PDF]

Hepatology, 2006
The practicing clinician is currently faced with a number of treatment options for chronic hepatitis B. Beginning in 1998 with the licensing of lamivudine and subsequently adefovir, the treatment paradigm shifted from 4 to 6 months of conventional alfa interferon to a year of nucleoside analog
openaire   +2 more sources

Viral suppression of RNA silencing by destabilization of ARGONAUTE 1 [PDF]

Plant Signaling & Behavior, 2008
RNA silencing is a manifestation of a ubiquitous phenomenon that acts, at least in plants and some insects, as a natural defense mechanism against viruses. As a counter-strategy, viruses have evolved to encode silencing suppressor proteins (SSPs) that can block the defense response and evade the host immunity. Although numerous SSP have been identified,
Bortolamiol, D., Pazhouhandeh, M., Ziegler-Graff, V.   +2 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania

BMC Infectious Diseases
Background The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed.
Monica S Kahabuka, Yimtubezinash Woldeamanuel, Peter M. Mbelele, Emmanuel A. Mpolya, Stellah G. Mpagama, Jonas P. Kessy, Tsegahun Manyazewal   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Factors associated with HIV RNA viral non-suppression among children and adolescents with HIV attending public health facilities in Gulu City, Uganda: a retrospective cohort study

Therapeutic Advances in Infectious Disease
Background: Human immunodeficiency virus (HIV) RNA viral load testing is the gold standard for monitoring antiretroviral therapy (ART), and sustained viral suppression is critical for preventing HIV-related morbidity and transmission.
Ventrina Lanyero, Felix Bongomin, Daniel S. Ebbs, Ritah Nantale, Emmanuel Ochola   +4 more
doaj   +1 more source