Results 51 to 60 of about 1,274,523 (300)

Alcohol use and depression: link with adherence and viral suppression in adult patients on antiretroviral therapy in rural Lesotho, Southern Africa: a cross-sectional study [PDF]

, 2016
BACKGROUND: Depression and alcohol use disorder have been shown to be associated with poor adherence to antiretroviral therapy (ART). Studies examining their association with viral suppression in rural Africa are, however, scarce.
Likabelo Toti-Mokoteli, Masetsibi, Motlomelo, Cerutti, Bernard, Bader, Joelle, Labhardt, Niklaus D, Broers, Barbara, Klimkait, Thomas, Niklaus D Labhardt, Bernard Cerutti, Joelle Bader, Motlomelo Masetsibi, Faturiyele, Olatunbosun, Olatunbosun Faturiyele, Motlatsi, Mokete, Thomas Klimkait, Toti-Mokoteli, Likabelo, Barbara Broers, Labhardt, Niklaus D., Mokete Motlatsi   +18 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of Age on Retention in Care and Viral Suppression [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015
Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to effect viral suppression. We evaluated whether the association between retention and viral suppression differed by age at entry into care.
Baligh R, Yehia, Peter, Rebeiro, Keri N, Althoff, Allison L, Agwu, Michael A, Horberg, Hasina, Samji, Sonia, Napravnik, Kenneth, Mayer, Ellen, Tedaldi, Michael J, Silverberg, Jennifer E, Thorne, Ann N, Burchell, Sean B, Rourke, Anita, Rachlis, Angel, Mayor, Michael J, Gill, Anne, Zinski, Michael, Ohl, Kathryn, Anastos, Alison G, Abraham, Mari M, Kitahata, Richard D, Moore, Kelly A, Gebo   +22 more
openaire   +2 more sources

Viral load suppression in HIV-infected adolescents in cameroon: towards achieving the UNAIDS 95% viral suppression target

BMC Pediatrics, 2023
Abstract Background Achieving the UNAIDS 95% sustained viral suppression (VS) rate requires considerable global efforts, particularly among adolescents living with HIV (ALHIV) who are often associated with high rates of virological failure (VF).
Djiyou, Armando, Penda, Calixte Ida, Madec, Yoann, Ngondi, Grace Dalle, Moukoko, Astrid, Varloteaux, Marie, de Monteynard, Laure-Amélie, Moins, Cecile, Moukoko, Carole Else Eboumbou, Aghokeng, Avelin   +9 more
openaire   +4 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Accuracy of Provider Predictions of Viral Suppression Among Adolescents and Young Adults With HIV in an HIV Clinical Program

Journal of the International Association of Providers of AIDS Care
Background Providers caring for adolescents and young adults with HIV (AYA-HIV) mostly base their adherence counseling during clinical encounters on clinical judgment and expectations of patients’ medication adherence.
Johannes Thrul PhD, Hasiya Yusuf MD, MPH, Janardan Devkota MS, MPH, Jill Owczarzak PhD, MA, Elise Tirza Ohene-Kyei MD, MPH, Kelly Gebo MD, MPH, Allison Agwu MD, ScM, FAAP, FIDSA   +6 more
doaj   +1 more source

Level of viral load suppression in Rwinkwavu District Hospital: A cross-sectional study

Journal of Interventional Epidemiology and Public Health
Introduction: The Rwinkwavu district hospital faces challenges in understanding and improving the human immunodeficiency virus viral load suppression rates among patients receiving antiretroviral therapy.
Metuschelah Habimana, Rachel Niyogushimwa, Vedaste Ndahindwa, Theoneste Ntakirutimana   +3 more
doaj   +1 more source

Suppression of viral infectivity through lethal defection [PDF]

Proceedings of the National Academy of Sciences, 2005
RNA viruses replicate with a very high error rate and give rise to heterogeneous, highly plastic populations able to adapt very rapidly to changing environments. Viral diseases are thus difficult to control because of the appearance of drug-resistant mutants, and it becomes essential to seek mechanisms able to force the extinction of the quasispecies ...
Grande-Pérez, Ana, Lázaro, Ester, Lowenstein, Pedro R., Domingo, Esteban, Manrubia Cuevas, Susanna   +4 more
openaire   +3 more sources

Failure to Attain HIV Viral Suppression After Intensified Adherence Counselling—What Can We Learn About Its Factors?

, 2023
James Samwel Mundamshimu,1 Kija Malale,1 Benson R Kidenya,1 Daniel W Gunda,1 Logious Bwemelo,1,* Mwakile Mwashiuya,1,* Salhida Shamnte Omar,1,* Neema Mlowe,1,* Magwa Kiyumbi,1 James S Ngocho,2,3 Emmanuel Balandya,4 Bruno Sunguya,4 Stephen
Mteta K, Kalluvya S, Bartlett J, Mshana SE, Malale K, Omar SS, Kiyumbi M, Lyamuya E, Mwashiuya M, Mmbaga BT, Balandya E, Kidenya BR, Mlowe N, Ngocho JS, Sunguya B, Gunda DW, Mundamshimu JS, Bwemelo L   +17 more
core