Results 71 to 80 of about 1,274,523 (300)

Viral induction and suppression of RNA silencing in plants

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
RNA silencing in plants and insects can function as a defence mechanism against invading viruses. RNA silencing-based antiviral defence entails the production of virus-derived small interfering RNAs which guide specific antiviral effector complexes to inactivate viral genomes. As a response to this defence system, viruses have evolved viral suppressors
Shimura, H., Pantaleo, V.
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Short-Cycle Therapy in Adolescents after Continuous Therapy with Established Viral Suppression: The Impact on Viral Load Suppression [PDF]

AIDS Research and Human Retroviruses, 2009
This was a proof-of-principle study to evaluate the impact of short cycle therapy (SCT; 4 days on/3 days off) in adolescents and young adults with good viral suppression on a protease inhibitor-based antiretroviral regimen. Subjects were recruited by the Adolescent Trials Network for HIV/AIDS Interventions and the Pediatric AIDS Clinical Trials Group ...
Bret J, Rudy, John, Sleasman, Bill, Kapogiannis, Craig M, Wilson, James, Bethel, Leslie, Serchuck, Sushma, Ahmad, Coleen K, Cunningham   +7 more
openaire   +2 more sources

Viral suppression among HIV-positive patients on antiretroviral therapy in northwestern Nigeria: an eleven-year review of tertiary care centre records, January 2009–December 2019

BMC Infectious Diseases, 2021
Background Human Immuno-Deficiency Virus (HIV) remains one of the world’s significant public health challenges. Viral suppression is the key indicator for treatment success in People living with HIV (PLHIV).
Suleiman Bello Abdullahi, Olayinka Rasheed Ibrahim, Abdulkadir Baba Okeji, Rabilu Iliyasu Yandoma, Ibrahim Bashir, Suleiman Haladu, Suleiman Ahmad Idris, T. I. A. Oseni, Bello Muhammad Suleiman, Mohammed Yahaya, Mabel Kamweli Aworh, Mu’awiyyah Babale Sufiyan   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

“I desire to have an HIV-free baby”: pregnant and breastfeeding mothers’ perceptions of Viral load testing and suppression in HIV care in southwestern Uganda

Discover Social Science and Health
Introduction Viral suppression is a critical component for preventing mother-to-child transmission of HIV(MTCT). Mothers’ perceptions of viral load suppression is crucial in the attainment of successful outcomes in preventing mother to child transmission
Jane Kabami, Cecilia Akatukwasa, Stella Kabageni, Joanita Nangendo, Ambrose Byamukama, Fredrick Atwiine, Valence Mfitumukiza, John Bosco Tamu Munezero, Elizabeth Arinaitwe, Andrew Mutabazi, Peter Ssebutinde, Phillipa Musoke, Moses R. Kamya, Anne R. Katahoire   +13 more
doaj   +1 more source

Viral suppression

, 2018
Viral suppression for HIV-infected pregnant women initiating ART for the first ...
Maganizo B Chagomerana (5059979), Chagomerana, Maganizo B   +1 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Factors associated with viral suppression and rebound among adult HIV patients on treatment: a retrospective study in Ghana

AIDS Research and Therapy, 2022
Background Viral suppression remains the most desired outcome in the management of patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and this can be achieved by an effective Antiretroviral Therapy (ART).
Stephen Opoku, Samuel Asamoah Sakyi, Nana Kwame Ayisi-Boateng, Anthony Kwame Enimil, Ebenezer Senu, Richard Owusu Ansah, Bismark Dankwah Aning, Diana Atsieno Ojuang, Doreen Nafula Wekesa, Fatima Osman Ahmed, Chidinma B. Okeke, Ama Darkoaa Sarfo   +11 more
doaj   +1 more source