Results 131 to 140 of about 614,007 (276)

Myeloid Cells Are Enriched in Tonsillar Crypts, Providing Insight into the Viral Tropism of Human Papillomavirus. [PDF]

Am J Pathol, 2021
Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI.   +15 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Differential tissue tropism and transmission efficiency of two dominant influenza D clades with overlapping but distinct receptor binding fine specificities in ferrets.

PLoS Pathogens
Influenza D virus (IDV) utilizes bovines as a primary reservoir causing periodical spillover to pigs and other hosts. In this study, we utilized ferrets to study IDV with a focus on the role of the Hemagglutinin-Esterase-Fusion (HEF) protein in the ...
Tirth Uprety, Chithra C Sreenivasan, Jieshi Yu, Miaoyun Zhao, Runxia Liu, Hai Yu, Ahsan Naveed, Lianne G Eertink, Shalini Soni, Rebecca E Ruby, Xi Chen, Radhey S Kaushik, Zizhang Sheng, Qingsheng Li, Dan Wang, Feng Li   +15 more
doaj   +1 more source

COVID-19-associated Aspergillus tracheobronchitis: the interplay between viral tropism, host defence, and fungal invasion. [PDF]

Lancet Respir Med, 2021
van de Veerdonk FL, Brüggemann RJM, Vos S, De Hertogh G, Wauters J, Reijers MHE, Netea MG, Schouten JA, Verweij PE.   +8 more
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Cutaneous-Tropism Viruses: Unraveling Pathogenetic Mechanisms and Immunoprophylactic Strategies

Life
Cutaneous viral infections result from the complex interaction between viruses and skin structures, influenced by viral tropism and the host immune response.
Mariana Lupoae, Alina Mihaela Elisei, Ancuța Iacob, Andreea Lupoae, Alin Laurențiu Tatu, Elena Niculeț, Maria Nina Căuș, Denisa Batîr, Aurel Nechita, Mădălina Nicoleta Matei, Claudia Simona Ștefan, Elena Lăcrămioara Lisă, Lungu Irinel, Dana Tutunaru   +13 more
doaj   +1 more source

Viral tropism and detection of clade 2.3.4.4b H5N8 highly pathogenic avian influenza viruses in feathers of ducks and geese. [PDF]

Sci Rep, 2021
Gaide N, Foret-Lucas C, Figueroa T, Vergne T, Lucas MN, Robertet L, Souvestre M, Croville G, Le Loc'h G, Delverdier M, Guérin JL.   +10 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19

Journal of Virology
Systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to extrapulmonary tissues has been observed following acute infections. Autopsy studies further indicate tissue-specific virus diversity, including in immune-privileged sites.
Katherine E. E. Johnson, Sydney Stein, Rita Afriyie Boateng, Shilpi Jain, Sabrina C. Ramelli, Trevor Stantliff, Shelly Curran, Marcos J. Ramos-Benítez, Andrew P. Platt, Stephanie Banakis, Wei Wang, Stephen M. Hewitt, Christa Zerbe, Steven M. Holland, Elizabeth M. Kang, Manmeet Singh, Emmie de Wit, William A. Lauer, Eric C. Rouchka, Melissa Smith, Mehul S. Suthar, Daniel S. Chertow, Elodie Ghedin   +22 more
doaj   +1 more source

Temperature dependent viral tropism: understanding viral seasonality and pathogenicity as applied to the avoidance and treatment of endemic viral respiratory illnesses. [PDF]

Rev Med Virol, 2022
Shaw Stewart PD, Bach JL.
europepmc   +1 more source