Results 1 to 10 of about 1,560,419 (396)
Transmissible Viral Vaccines. [PDF]
Trends Microbiol, 2018 Genetic engineering now enables the design of live viral vaccines that are potentially transmissible. Some designs merely modify a single viral genome to improve on the age-old method of attenuation whereas other designs create chimeras of viral genomes.
Bull JJ, Smithson MW, Nuismer SL.
europepmc +6 more sources
Inactivated Viral Vaccines [PDF]
Vaccine Analysis: Strategies, 2014 Inactivated vaccines have been used for over a century to induce protection against viral pathogens. This established approach of vaccine production is relatively straightforward to achieve and there is an augmented safety profile as compared to their live counterparts.
Sanders B, Koldijk M, Schuitemaker H.
europepmc +4 more sources
An Update on mRNA-Based Viral Vaccines. [PDF]
Vaccines (Basel), 2021 With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ...
Jeeva S +4 more
europepmc +2 more sources
Future perspectives on swine viral vaccines: where are we headed? [PDF]
Porcine Health Manag, 2021 Deliberate infection of humans with smallpox, also known as variolation, was a common practice in Asia and dates back to the fifteenth century. The world’s first human vaccination was administered in 1796 by Edward Jenner, a British physician. One of the
Opriessnig T +3 more
europepmc +2 more sources
Early type I IFN blockade improves the efficacy of viral vaccines. [PDF]
J Exp Med, 2020 IFN-I provide a rapid antiviral defense, but they limit antigen availability during priming. Here, the authors demonstrate that short-term IFN-I blockade after primary viral infection improves adaptive immunity and protection against reinfection.
Palacio N +6 more
europepmc +2 more sources
Current Opinion in Immunology, 2022 Over the past two years, the SARS-CoV-2 pandemic has highlighted the impact that emerging pathogens can have on global health. The development of new and effective vaccine technologies is vital in the fight against such threats. Viral vectors are a relatively new vaccine platform that relies on recombinant viruses to deliver selected immunogens into ...
McCann, N +3 more
openaire +4 more sources
The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines. [PDF]
NPJ Vaccines, 2020 The outbreak of 2019-novel coronavirus disease (COVID-19) that is caused by SARS-CoV-2 has spread rapidly in China, and has developed to be a Public Health Emergency of International Concern.
Shang W, Yang Y, Rao Y, Rao X.
europepmc +2 more sources
Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy. [PDF]
ACS OmegaIn the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional cancer vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration of the methodologies,
Mohite P +10 more
europepmc +2 more sources
The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines. [PDF]
Viruses, 2020 Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Mok DZL, Chan KR.
europepmc +2 more sources
Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. [PDF]
Sci Rep, 2019 Most currently available vaccines, particularly live vaccines, require the cold chain, as vaccine efficacy can be significantly hampered if they are not stored in a temperature range of 2–8 °C at all times.
Leung V +12 more
europepmc +2 more sources