Results 41 to 50 of about 1,005,947 (300)

MODELLING OF HEPATITIS E IN MINI-PIGS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2017
Aim. Experimental reproduction of HEV-infection in mini-pigs and comparative analysis of virological and immunological characteristics of experimental infection. Materials and methods.
S. A. Gulyaev, I. A. Potemkin, V. S. Kichatova, A. A. Karlsen, O. V. Isaeva, T. V. Guiyaeva, M. A. Vannus, I. V. Gordeichuk, K. K. Kyuregyan, M. I. Mikhailov   +9 more
doaj   +1 more source

SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Nature Communications, 2021
Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and ...
Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie   +11 more
doaj   +1 more source

The Immunological and Epidemiological Effectiveness of Pediatric Single-Dose Vaccination against Hepatitis A 9 to 11 Years after Its Implementation in the Tyva Republic, the Russian Federation

Vaccines
Since 2012, universal single-dose HAV vaccination in children aged 3 years and older has been implemented in the Tyva Republic, a region of the Russian Federation.
Maria A. Lopatukhina, Karen K. Kyuregyan, Anastasia A. Karlsen, Fedor A. Asadi Mobarkhan, Ilya A. Potemkin, Vera S. Kichatova, Olga V. Isaeva, Lyudmila Yu. Ilchenko, Anna A. Saryglar, Mikhail I. Mikhailov   +9 more
doaj   +1 more source

Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19

, 2022
The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission ...
Aiquan Chang, Jingyou Yu
core   +1 more source

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

Vaccines, 2021
Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population.
Karen K. Kyuregyan, Vera S. Kichatova, Olga V. Isaeva, Ilya A. Potemkin, Elena Yu. Malinnikova, Maria A. Lopatukhina, Anastasia A. Karlsen, Fedor A. Asadi Mobarhan, Eugeniy V. Mullin, Olga S. Slukinova, Margarita E. Ignateva, Snezhana S. Sleptsova, Elena E. Oglezneva, Elena V. Shibrik, Maria G. Isaguliants, Mikhail I. Mikhailov   +15 more
doaj   +1 more source

Matrix and Backstage: Cellular Substrates for Viral Vaccines

, 2014
Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of ...
Ingo Jordan, Volker Sandig
core   +1 more source

Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action

, 2023
Neuraminidase (NA) is an important surface protein on influenza virions, playing an essential role in the viral life cycle and being a key target of the immune system.
Nada Abbadi, Mousa, Jarrod J., Abbadi, Nada, Jarrod J. Mousa   +3 more
core   +1 more source

Vaccines in the Prevention of Viral Pneumonia [PDF]

Clinics in Chest Medicine, 2017
Pneumonia is of great global public health importance. Viral infections play both direct and indirect parts in its cause across the globe. Influenza is a leading cause of viral pneumonia in both children and adults, and respiratory syncytial virus is increasingly recognized as causing disease at both extremes of age.
Fraser, CS, Jha, A, Openshaw, PJM
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Viral vaccines for farmed finfish [PDF]

VirusDisease, 2013
Over the past decade, aquaculture has grown at an average annual growth rate of approximately 6 % worldwide despite many challenges. Viral diseases are one of the major challenges that are threatening a sustainable growth of finfish farming globally.
Arun K, Dhar, Sanjib K, Manna, F C, Thomas Allnutt   +2 more
openaire   +2 more sources