Results 21 to 30 of about 949,142 (303)

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

iScience, 2021
Summary: Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2 convalescent plasma (CP) are under evaluation in clinical trials. Here we explored the antibody epitope repertoire, and virus neutralizing capacity of six hCoV-2IG batches as well ...
Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B. Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana   +9 more
doaj   +1 more source

Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures

Vaccines, 2021
The ongoing COVID-19 pandemic drew global attention to infectious diseases, attracting numerous resources for development of pandemic preparedness plans and vaccine platforms—technologies with robust manufacturing processes that can quickly be pivoted to
Julia Puppin Chaves Fulber, Omar Farnós, Sascha Kiesslich, Zeyu Yang, Shantoshini Dash, Leonardo Susta, Sarah K. Wootton, Amine A. Kamen   +7 more
doaj   +1 more source

Preclinical immunogenicity assessment of a cell-based inactivated whole-virion H5N1 influenza vaccine

Open Life Sciences, 2022
In influenza vaccine development, Madin–Darby canine kidney (MDCK) cells provide multiple advantages, including large-scale production and egg independence. Several cell-based influenza vaccines have been approved worldwide.
Zhang Zhegang, Jiang Zheng, Deng Tao, Zhang Jiayou, Liu Bo, Liu Jing, Qiu Ran, Zhang Qingmei, Li Xuedan, Nian Xuanxuan, Hong Yue, Li Fang, Peng Feixia, Zhao Wei, Xia Zhiwu, Huang Shihe, Liang Shuyan, Chen Jinhua, Li Changgui, Yang Xiaoming   +19 more
doaj   +1 more source

Viral vector vaccines

Current Opinion in Immunology, 2022
Over the past two years, the SARS-CoV-2 pandemic has highlighted the impact that emerging pathogens can have on global health. The development of new and effective vaccine technologies is vital in the fight against such threats. Viral vectors are a relatively new vaccine platform that relies on recombinant viruses to deliver selected immunogens into ...
McCann, N, O'Connor, D, Lambe, T, Pollard, AJ   +3 more
openaire   +3 more sources

Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use

Viruses, 2022
The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can rapidly be developed and manufactured on a large scale to immunize the population against emerging viruses.
Julia P. C. Fulber, Amine A. Kamen
doaj   +1 more source

Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses

npj Vaccines, 2021
Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic.
Peter Radvak, Martina Kosikova, Yuan-Chia Kuo, Xing Li, Richard Garner, Falko Schmeisser, Ivan Kosik, Zhiping Ye, Jerry P. Weir, Jonathan W. Yewdell, Hang Xie   +10 more
doaj   +1 more source

Capripoxvirus antibodies detection: Relationship between the two methods alpha and beta of virus neutralisation test [PDF]

Open Veterinary Journal, 2018
Virus neutralisation test (VNT) of capripoxvirus (CaPVs) was studied to assess the post-vaccination (vaccine effectiveness) or post-infection antibodies level using two methods: alpha-VNT and beta-VNT which are generally carried out to measure the ...
Mohamed Hamidouche, Nassira Belmessabih, Abderrahmane Boubguira, Amina Benfenatki, Naim Saada, Amina Sail, Fatima Bacha   +6 more
doaj   +1 more source

A Review on Rubella Vaccine: Iran (1975-2019) [PDF]

Archives of Razi Institute, 2021
The first Attenuated rubella vaccine was developed by Parkman and Meyer in 1966. Ten years later in the 1975s, the rubella vaccine was developed in Razi Vaccine and serum research institute) RVSRI).
A Shafayi, A Mohammadi
doaj   +1 more source

Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”?

Viruses, 2023
The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav, Martina Kosikova, Peter Radvak, Yuan-Chia Kuo, Hyung Joon Kwon, Hang Xie   +5 more
doaj   +1 more source

Phylodynamic Analysis Suggests That Deer Species May Be a True Reservoir for Hepatitis E Virus Genotypes 3 and 4

Microorganisms, 2023
Hepatitis E virus (HEV) genotypes 3 and 4 (HEV-3 and HEV-4) cause zoonotic infection in humans, with domestic pigs and wild boars being the main reservoirs of infection.
Anastasia A. Karlsen, Vera S. Kichatova, Karen K. Kyuregyan, Mikhail I. Mikhailov   +3 more
doaj   +1 more source