Results 11 to 20 of about 949,142 (303)
To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity
Viruses, 2021 Direct-acting antiviral agents have proven highly effective at treating existing hepatitis C infections but despite their availability most countries will not reach the World Health Organization targets for elimination of HCV by 2030.
Felicia Schlotthauer +2 more
doaj +2 more sources
An Update on mRNA-Based Viral Vaccines. [PDF]
Vaccines (Basel), 2021 With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ...
Jeeva S +4 more
europepmc +2 more sources
Temperature-Dependent Viral Pathogenicity: Implications for Attenuation of Viral Vaccines. [PDF]
VirusesThis review highlights the role of temperature sensitivity, a common feature of attenuated virus vaccines, in mediating attenuation. Viral attenuation mechanisms were analyzed by comparing vaccine characteristics and genes with those of wild-type viruses.
Shiraki K, Kawana T, Whitley RJ.
europepmc +2 more sources
Transmissible Viral Vaccines [PDF]
Trends in Microbiology, 2018 Genetic engineering now enables the design of live viral vaccines that are potentially transmissible. Some designs merely modify a single viral genome to improve on the age-old method of attenuation whereas other designs create chimeras of viral genomes.
Bull, James J. +2 more
openaire +3 more sources
The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines. [PDF]
Viruses, 2020 Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Mok DZL, Chan KR.
europepmc +2 more sources
Using the Past to Maximize the Success Probability of Future Anti-Viral Vaccines. [PDF]
Vaccines (Basel), 2020 Rapid obtaining of safe, effective, anti-viral vaccines has recently risen to the top of the international agenda. To maximize the success probability of future anti-viral vaccines, the anti-viral vaccines successful in the past are summarized here by ...
Serwer P.
europepmc +2 more sources
Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundViral vaccines have been proven significant in protecting us against viral diseases such as COVID-19. To better understand and design viral vaccines, it is critical to systematically collect, annotate, and analyse various viral vaccines and ...
Anthony Huffman +8 more
doaj +2 more sources
60 Years of viral vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2022 Wahren B.
openaire +4 more sources
Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines
Vaccines, 2022 New influenza strains are constantly emerging, causing seasonal epidemics and raising concerns to the risk of a new global pandemic. Since vaccination is an effective method to prevent the spread of the disease and reduce its severity, the development of
Zeyu Yang +10 more
doaj +1 more source
Vaccines, 2023 The administration of viral vectored vaccines remains one of the most effective ways to respond to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic.
Zeyu Yang +5 more
doaj +1 more source