Results 11 to 20 of about 1,005,947 (300)

An Update on mRNA-Based Viral Vaccines. [PDF]

Vaccines (Basel), 2021
With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ...
Jeeva S, Kim KH, Shin CH, Wang BZ, Kang SM.   +4 more
europepmc   +2 more sources

Temperature-Dependent Viral Pathogenicity: Implications for Attenuation of Viral Vaccines. [PDF]

Viruses
This review highlights the role of temperature sensitivity, a common feature of attenuated virus vaccines, in mediating attenuation. Viral attenuation mechanisms were analyzed by comparing vaccine characteristics and genes with those of wild-type viruses.
Shiraki K, Kawana T, Whitley RJ.
europepmc   +2 more sources

The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines. [PDF]

Viruses, 2020
Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Mok DZL, Chan KR.
europepmc   +2 more sources

60 Years of viral vaccines. [PDF]

Hum Vaccin Immunother, 2022
Wahren B.
europepmc   +5 more sources

Transmissible Viral Vaccines. [PDF]

Trends Microbiol, 2018
Genetic engineering now enables the design of live viral vaccines that are potentially transmissible. Some designs merely modify a single viral genome to improve on the age-old method of attenuation whereas other designs create chimeras of viral genomes.
Bull JJ, Smithson MW, Nuismer SL.
europepmc   +4 more sources

The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of inactivated viral vaccines. [PDF]

Vaccine, 2020
Inactivated viral vaccines have long been used in humans for diseases of global health threat and are now among the vaccines for COVID-19 under development.
Kochhar S, Excler JL, Kim D, Robertson JS, Fast PE, Condit RC, Drew S, Wood D, Gurwith M, Klug B, Whelan M, Khuri-Bulos N, Mallett Moore T, Smith ER, Chen RT, Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG). Electronic address: brightoncollaborationv3swg@gmail.com.   +15 more
europepmc   +2 more sources

Viral vector vaccines

Current Opinion in Immunology, 2022
Over the past two years, the SARS-CoV-2 pandemic has highlighted the impact that emerging pathogens can have on global health. The development of new and effective vaccine technologies is vital in the fight against such threats. Viral vectors are a relatively new vaccine platform that relies on recombinant viruses to deliver selected immunogens into ...
McCann, N, O'Connor, D, Lambe, T, Pollard, AJ   +3 more
openaire   +3 more sources

Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”?

Viruses, 2023
The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav, Martina Kosikova, Peter Radvak, Yuan-Chia Kuo, Hyung Joon Kwon, Hang Xie   +5 more
doaj   +1 more source

A Review on Rubella Vaccine: Iran (1975-2019) [PDF]

Archives of Razi Institute, 2021
The first Attenuated rubella vaccine was developed by Parkman and Meyer in 1966. Ten years later in the 1975s, the rubella vaccine was developed in Razi Vaccine and serum research institute) RVSRI).
A Shafayi, A Mohammadi
doaj   +1 more source

Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances

, 2022
Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry.
Guo, Jinshuo, Jue Liu, Zhou, Jianwei, Liu, Jue, Hou, Lei, Dedong Wang, Yongqiu Cui, Xufei Feng, Lei Hou, Jinshuo Guo, Jianwei Zhou, Cui, Yongqiu, Wang, Dedong, Feng, Xufei   +13 more
core   +1 more source