Results 51 to 60 of about 257,933 (304)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Development of Robust Freeze-Drying Process for Long-Term Stability of rVSV-SARS-CoV-2 Vaccine

Viruses
The thermostability of vaccines, particularly enveloped viral vectored vaccines, remains a challenge to their delivery wherever needed. The freeze-drying of viral vectored vaccines is a promising approach but remains challenging due to the water removal ...
MD Faizul Hussain Khan, Maryam Youssef, Sean Nesdoly, Amine A. Kamen   +3 more
doaj   +1 more source

Genome Analysis and Replication Studies of the African Green Monkey Simian Foamy Virus Serotype 3 Strain FV2014

Viruses, 2020
African green monkey (AGM) spumaretroviruses have been less well-studied than other simian foamy viruses (SFVs). We report the biological and genomic characterization of SFVcae_FV2014, which was the first foamy virus isolated from an African green monkey
Sandra M. Fuentes, Eunhae H. Bae, Subhiksha Nandakumar, Dhanya K. Williams, Arifa S. Khan   +4 more
doaj   +1 more source

Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond

iScience, 2022
Summary: Here we interrogate the factors responsible for SARS-CoV-2 breakthrough infections in a K18-hACE2 transgenic mouse model. We show that Delta and the closely related Kappa variant cause viral pneumonia and severe lung lesions in K18-hACE2 mice ...
Hyung-Joon Kwon, Martina Kosikova, Weichun Tang, Uriel Ortega-Rodriguez, Peter Radvak, Ruoxuan Xiang, Kelly E. Mercer, Levan Muskhelishvili, Kelly Davis, Jerrold M. Ward, Ivan Kosik, Jaroslav Holly, Insung Kang, Jonathan W. Yewdell, Ewan P. Plant, Wilbur H. Chen, Mallory C. Shriver, Robin S. Barnes, Marcela F. Pasetti, Bin Zhou, David E. Wentworth, Hang Xie   +21 more
doaj   +1 more source

Matrix and Backstage: Cellular Substrates for Viral Vaccines

, 2014
Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of ...
Ingo Jordan, Volker Sandig
core   +1 more source

Improved adjuvanting of seasonal influenza vaccines: Pre-clinical studies of MVA-NP+M1 co-administration with inactivated influenza vaccine. [PDF]

, 2013
Licensed seasonal influenza vaccines induce antibody responses against influenza hemagglutinin that are limited in their ability to protect against different strains of influenza.
Gilbert, SC, Temperton, Nigel J., Charleston, Bryan, Molesti, E, Sarah C. Gilbert, Butter, Colin, Massimiliano Baratelli, Lambe, Teresa, Boyd, A, Mullarkey, CE, Charleston, B, Caitlin E. Mullarkey, Eleonora Molesti, Gilbert, Sarah, van Laarhoven, Arjan, Veronica Carr, B, van Laarhoven, A, Eric A. Lefevre, Molesti, Eleonora, Amy Boyd, Colin Butter, Mullarkey, Caitlin E, Gilbert, Sarah C, Lefevre, EA, B. Veronica Carr, Arjan van Laarhoven, Nigel J. Temperton, Lambe, T, Baratelli, M, Carr, B Veronica, Baratelli, Massimiliano, Lefevre, Eric A, Boyd, Amy, Temperton, NJ, Butter, C, Teresa Lambe, Bryan Charleston   +36 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Oral Poliovirus Vaccine (OPV) Manufacturing in Iran over Five Decades: from tOPV to bOPV and Future Planned Cessation [PDF]

Archives of Razi Institute
By the early 1970s, there were no manufacturers in Iran producing oral poliovirus vaccine (OPV). The only domestic OPV was produced by the Razi Vaccine and Serum Research Institute (RVSRI) in 1974 after receiving the Sabin seeds on 5 January 1973.
Behnam Alirezaie, Ashraf Mohammadi
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Vaccines in the Prevention of Viral Pneumonia [PDF]

Clinics in Chest Medicine, 2017
Pneumonia is of great global public health importance. Viral infections play both direct and indirect parts in its cause across the globe. Influenza is a leading cause of viral pneumonia in both children and adults, and respiratory syncytial virus is increasingly recognized as causing disease at both extremes of age.
Fraser, CS, Jha, A, Openshaw, PJM
openaire   +3 more sources