Results 71 to 80 of about 257,933 (304)

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity

open access: yesViruses, 2021
The SARS-CoV-2 B.1.617 lineage variants, Kappa (B.1.617.1) and Delta (B.1.617.2, AY) emerged during the second wave of infections in India, but the Delta variants have become dominant worldwide and continue to evolve.
Sabari Nath Neerukonda   +10 more
doaj   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

open access: yesAdvanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett   +19 more
wiley   +1 more source

Universal Single-Dose Vaccination against Hepatitis A in Children in a Region of High Endemicity

open access: yesVaccines, 2020
Since August 2012, universal single-dose vaccination in children aged at least three years has been implemented in the Republic of Tuva, which was previously the region most affected by hepatitis A in Russia.
Mikhail I. Mikhailov   +11 more
doaj   +1 more source

Measles Vaccines Designed for Enhanced CD8+ T Cell Activation

open access: yes, 2020
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of ...
Johanna K. M. Mayer   +13 more
core   +1 more source

Inflammatory Control of Viral Infection

open access: yes, 2023
Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases.
Ritu Chakravarti   +2 more
core   +1 more source

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies [PDF]

open access: yes, 2022
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19 pandemic owing to rapid development, effectiveness, and scalability to meet the global demand.
Bello, Muhammad Bashir   +4 more
core   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

open access: yesAdvanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park   +15 more
wiley   +1 more source

Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus

open access: yesViruses, 2021
There is a large unmet need for a prophylactic vaccine against human cytomegalovirus (HCMV) to combat the ubiquitous infection that is ongoing with this pathogen.
Sanda Ravlić   +4 more
doaj   +1 more source

Viral veterinary vaccines.

open access: yesDevelopments in biological standardization, 1999
The value of animal models for assessing the quality of veterinary viral vaccines is not to be despised, particularly since one has access to target animal models which are often more relevant than those in the laboratory, especially for challenge/protection studies. Immune protection involves complex immunological phenomena and processes.
Pastoret, Paul-Pierre, Falize, F.
openaire   +2 more sources

Prophylactic Hepatitis E Vaccines: Antigenic Analysis and Serological Evaluation

open access: yes, 2020
Hepatitis E virus (HEV) infection causes sporadic outbreaks of acute hepatitis worldwide. HEV was previously considered to be restricted to resource-limited countries with poor sanitary conditions, but increasing evidence implies that HEV is also a ...
Jun Zhang   +6 more
core   +1 more source

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