Results 161 to 170 of about 949,142 (303)

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Monogenic susceptibility to live viral vaccines. [PDF]

Curr Opin Immunol, 2021
Gothe F, Howarth S, Duncan CJ, Hambleton S.   +3 more
europepmc   +1 more source

Breaching the Barrier: Investigating Initial Herpes Simplex Viral Infection and Spread in Human Skin and Mucosa

Herpes simplex virus (HSV) is sexually transmitted via the anogenital mucosa where it initially infects epidermal keratinocytes and mononuclear phagocytes (MNPs). It then spreads to the dorsal root ganglion via sensory nerve endings, to remain latent for
Naomi R. Truong, Anthony L. Cunningham, Dona R. Sirimanne, Hafsa Rana   +3 more
core   +1 more source

Causal analysis of trade loss from pathogens: A global study of foot and mouth disease impacts on meat exports

American Journal of Agricultural Economics, EarlyView.
Abstract Our general interest is in global trade loss from livestock pathogens, specifically exports. We adopt a causal inference approach that considers animal disease outbreaks over time as non‐staggered binary treatments with the potential for switching in (infection) and out of treatment (recovery) within the sample period. The outcome evolution of
Mohammad Maksudur Rahman, Thomas L. Marsh   +1 more
wiley   +1 more source

Safety, immunogenicity and pregnancy outcomes in mothers and infants after vaccination with an adenovirus-vector COVID-19 vaccine during pregnancy

Human Vaccines & Immunotherapeutics
COVID-19 during pregnancy can be associated with adverse pregnancy and infant outcomes. We assessed the safety, reactogenicity, and immunogenicity of maternal vaccination with Ad26.COV2.S COVID-19 vaccine and monitored serum and breast milk antibody ...
Gloria Aguilar, Gabriela Tapia-Calle, Cynthia Robinson, Benoit Baron, David Lowson, Bassem Maximos, Veronica V. Rezelj, Anne Marit de Groot, Nicole Bet, Vitalija van Paassen, Mathieu Le Gars, Frank Struyf, Javier Ruiz-Guiñazú   +12 more
doaj   +1 more source

Immunogenicity of Viral Vaccines in the Italian Military. [PDF]

Biomedicines, 2021
Ferlito C, Biselli R, Visco V, Cattaruzza MS, Capobianchi MR, Castilletti C, Lapa D, Nicoletti L, Marchi A, Magurano F, Ciccaglione AR, Chionne P, Madonna E, Donatelli I, Calzoletti L, Fabiani C, Biondo MI, Teloni R, Mariotti S, Salerno G, Picchianti-Diamanti A, Salemi S, Caporuscio S, Autore A, Lulli P, Borelli F, Lastilla M, Nisini R, D'Amelio R.   +28 more
europepmc   +1 more source

Monophosphoryl-Lipid A (MPLA) is an Efficacious Adjuvant for Inactivated Rabies Vaccines

, 2019
Rabies, as one of the most threatening zoonoses in the world, causes a fatal central nervous system (CNS) disease. So far, vaccination with rabies vaccines has been the most effective measure to prevent and control this disease.
Chen Chen, Ming Zhou, Chengguang Zhang, Zongmei Wang, Yueming Yuan, Zhenfang Fu, Ruiming Li, Haoqi Li, Ling Zhao   +8 more
core   +1 more source

Risk management externalities in agrifood supply chains

American Journal of Agricultural Economics, EarlyView.
Abstract Firms may under‐ or over‐invest in risk management from the social planner's perspective, resulting in a negative externality on other economic agents in the supply chain. The externality of risk management is particularly relevant for agrifood supply chains, which frequently experience disruptions and play a primary role in preventing major ...
Jeffrey Hadachek, Meilin Ma
wiley   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

A WHO global framework to guide investigations into origins of potentially epidemic and pandemic pathogens

Nature Communications
In outbreak situations involving a novel pathogen timely and coordinated response is crucial. The WHO Scientific Advisory Group for the Origins of Novel Pathogens recently released a global framework to guide future scientific investigations into the ...
The Scientific Advisory Committee for the Origins of Novel Pathogens (SAGO) and WHO SAGO Secretariat
doaj   +1 more source