Reference Module in Biomedical Sciences, 2014 Since antiquity, humans have strived to find ways to prevent the suffering and mortality caused by infectious pathogens. No interventions in medical history have had a bigger impact on human health than the development of preventative vaccines against infectious diseases.
Marconi, P +4 more
semanticscholar +4 more sources
An Update on mRNA-Based Viral Vaccines. [PDF]
Vaccines (Basel), 2021 With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ...
Jeeva S +4 more
europepmc +2 more sources
Early type I IFN blockade improves the efficacy of viral vaccines. [PDF]
J Exp Med, 2020 IFN-I provide a rapid antiviral defense, but they limit antigen availability during priming. Here, the authors demonstrate that short-term IFN-I blockade after primary viral infection improves adaptive immunity and protection against reinfection.
Palacio N +6 more
europepmc +2 more sources
A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens. [PDF]
VirusesPig farming has become a strategically significant and economically important industry across the globe. It is also a potentially vulnerable sector due to challenges posed by transboundary diseases in which viral infections are at the forefront.
Kamboj A +6 more
europepmc +2 more sources
Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines. [PDF]
Nat CommunDifferent approaches have been described for the transdermal delivery of drugs. Here the authors report the design of a fluorocarbon modified chitosan-based non-invasive transdermal platform for the delivery of biomacromolecules, such as viral antigens ...
Zhu W +11 more
europepmc +2 more sources
The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines. [PDF]
NPJ Vaccines, 2020 The outbreak of 2019-novel coronavirus disease (COVID-19) that is caused by SARS-CoV-2 has spread rapidly in China, and has developed to be a Public Health Emergency of International Concern.
Shang W, Yang Y, Rao Y, Rao X.
europepmc +2 more sources
Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy. [PDF]
ACS OmegaIn the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional cancer vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration of the methodologies,
Mohite P +10 more
europepmc +2 more sources
The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines. [PDF]
Viruses, 2020 Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Mok DZL, Chan KR.
europepmc +2 more sources
The CRISPR Journal, 2021 CRISPR-Cas technology, discovered originally as a bacterial defense system, has been extensively repurposed as a powerful tool for genome editing for multiple applications in biology.
N. Tang +4 more
semanticscholar +1 more source
Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. [PDF]
Sci Rep, 2019 Most currently available vaccines, particularly live vaccines, require the cold chain, as vaccine efficacy can be significantly hampered if they are not stored in a temperature range of 2–8 °C at all times.
Leung V +12 more
europepmc +2 more sources