Results 41 to 50 of about 1,490,578 (344)
Viral targets for vaccines against COVID-19
Nature reviews. Immunology, 2020 Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic and to help the return to pre-pandemic normalcy. A great many vaccine candidates are being developed, several of which have completed late-stage clinical trials and ...
L. Dai, G. Gao
semanticscholar +1 more source
Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines
npj Vaccines, 2021 Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading pathogens through recognition of pathogen-associated molecular patterns.
Rossella Sartorius +4 more
semanticscholar +1 more source
Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer?
Vaccines, 2021 Molecular pharming or the technology of application of plants and plant cell culture to manufacture high-value recombinant proteins has progressed a long way over the last three decades.
S. Venkataraman +3 more
semanticscholar +1 more source
medRxiv, 2021 The coronavirus disease-2019 (COVID-19) pandemic has become a severe healthcare problem worldwide since the first outbreak in late December 2019. Currently, the COVID-19 vaccine has been used in many countries, but it is still unable to control the ...
S. Kanokudom +14 more
semanticscholar +1 more source
Viruses, 2023 We previously reported a novel rhabdovirus produced from the Spodoptera frugiperda Sf9 cell line, designated as Sf-rhabdovirus X+ since it contained a unique accessory gene X.
Hailun Ma, Trent J. Bosma, Arifa S. Khan
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Review of COVID-19 viral vector-based vaccines and COVID-19 variants.
Le infezioni in medicina, 2021 The concept of viral vector-based vaccine was introduced in 1972 by Jackson et al and in 1982 Moss et al introduced the use of vaccinia virus as a transient gene expression vector.
Rachana Vanaparthy +3 more
semanticscholar +1 more source
Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development [PDF]
BioDrugs, 2021 Vaccine-associated enhanced disease (VAED) is a serious barrier to attaining successful virus vaccines in human and veterinary medicine. VAED occurs as two different immunopathologies, antibody-dependent enhancement (ADE) and vaccine-associated hypersensitivity (VAH).
openaire +2 more sources
Nature Communications, 2021 Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and ...
Peter Radvak +11 more
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Nature Communications, 2022 Here the authors show that a third SARS-CoV-2 vaccination significantly boosts neutralizing antibodies against Omicron subvariants and that hybrid immunity (infection and vaccination) results in broader neutralization activity and cross-reactive antibody
Lorenza Bellusci +6 more
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Vaccines, 2021 Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population.
Karen K. Kyuregyan +15 more
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