Results 41 to 50 of about 370,832 (346)

Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond

iScience, 2022
Summary: Here we interrogate the factors responsible for SARS-CoV-2 breakthrough infections in a K18-hACE2 transgenic mouse model. We show that Delta and the closely related Kappa variant cause viral pneumonia and severe lung lesions in K18-hACE2 mice ...
Hyung-Joon Kwon, Martina Kosikova, Weichun Tang, Uriel Ortega-Rodriguez, Peter Radvak, Ruoxuan Xiang, Kelly E. Mercer, Levan Muskhelishvili, Kelly Davis, Jerrold M. Ward, Ivan Kosik, Jaroslav Holly, Insung Kang, Jonathan W. Yewdell, Ewan P. Plant, Wilbur H. Chen, Mallory C. Shriver, Robin S. Barnes, Marcela F. Pasetti, Bin Zhou, David E. Wentworth, Hang Xie   +21 more
doaj   +1 more source

Molecular aspects of MERS-CoV [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Ahmed, Shamsah H., Al-Tawfiq, Jaffar A., Bazzi, Ali M., Rabaan, Ali A.   +3 more
core   +1 more source

Genome Analysis and Replication Studies of the African Green Monkey Simian Foamy Virus Serotype 3 Strain FV2014

Viruses, 2020
African green monkey (AGM) spumaretroviruses have been less well-studied than other simian foamy viruses (SFVs). We report the biological and genomic characterization of SFVcae_FV2014, which was the first foamy virus isolated from an African green monkey
Sandra M. Fuentes, Eunhae H. Bae, Subhiksha Nandakumar, Dhanya K. Williams, Arifa S. Khan   +4 more
doaj   +1 more source

Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisation strategy [PDF]

, 2018
Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection.
Alicino C., Ansaldi F., Calamusa G., Canepa P., Colomba G. M. E., Orsi A., Pojero F., Tramuto F., Trucchi C., Vitale F.   +9 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Development of Robust Freeze-Drying Process for Long-Term Stability of rVSV-SARS-CoV-2 Vaccine

Viruses
The thermostability of vaccines, particularly enveloped viral vectored vaccines, remains a challenge to their delivery wherever needed. The freeze-drying of viral vectored vaccines is a promising approach but remains challenging due to the water removal ...
MD Faizul Hussain Khan, Maryam Youssef, Sean Nesdoly, Amine A. Kamen   +3 more
doaj   +1 more source

Outside in – inside out. Creating focus on the patient – a vaccine company perspective

Human Vaccines & Immunotherapeutics, 2018
Involving patients in the development of medicines and vaccines should result in benefits to patients. The vaccine recipient is usually a healthy person.
Denis Sohy, Isabelle Dusart, Philibert Goulet, Diane Visy, Luc Gasthuys, Tatjana Poplazarova, Thomas Breuer, Norman Begg   +7 more
doaj   +1 more source

Validation of a Harmonized Enzyme-Linked-Lectin-Assay (ELLA-NI) Based Neuraminidase Inhibition Assay Standard Operating Procedure (SOP) for Quantification of N1 Influenza Antibodies and the Use of a Calibrator to Improve the Reproducibility of the ELLA-NI With Reverse Genetics Viral and Recombinant Neuraminidase Antigens: A FLUCOP Collaborative Study

Frontiers in Immunology, 2022
Current vaccination strategies against influenza focus on generating an antibody response against the viral haemagglutination surface protein, however there is increasing interest in neuraminidase (NA) as a target for vaccine development. A critical tool
Marie-Clotilde Bernard, Joanna Waldock, Sylvie Commandeur, Lea Strauß, Claudia Maria Trombetta, Serena Marchi, Fan Zhou, Serge van de Witte, Peter van Amsterdam, Sammy Ho, Katja Hoschler, Vladimir Lugovtsev, Jerry P. Weir, Emanuele Montomoli, Rebecca J. Cox, Othmar G. Engelhardt, Damien Friel, Ralf Wagner, Thierry Ollinger, Sophie Germain, Hanna Sediri-Schön   +20 more
doaj   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Determination of antibodies to Caprine arthritis encephalitis virus in goats and sheep in some localities in Sudan

Journal of Advanced Veterinary and Animal Research, 2016
Objective: Caprine arthritis encephalitis (CAE) infection is existing worldwide causing economic loss in goat production. This work was conducted to investigate the prevalence of CAE in local and foreign goat breeds and sheep in different localities in ...
Wegdan Hassan Ali, Intisar Kamil Saeed, Shaza Mohammed Mutwakil, Omer A. Algezoli, Abdelgader Ballal Mohammed, Ihsan Hussein Ahmed, Sahar Mohammed Elhassan, Baraa Abdelaziz Ahmed, Rayan M. A. Asil, Saafass M. A. Alsarraj, Abdelmhmoud Atalmanan Abdelgader and Yahia Hassan Ali   +10 more
doaj   +1 more source