Results 241 to 250 of about 657,629 (304)

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Strategic and Technical Considerations in Manufacturing Viral Vector Vaccines for the Biomedical Advanced Research and Development Authority Threats. [PDF]

Vaccines (Basel)
Parish LA, Rele S, Hofmeyer KA, Luck BB, Wolfe DN.   +4 more
europepmc   +1 more source

Buffer Valency Engineering Enables High-concentration and Shelf-stable DNA Transfection Particles for Viral Vector Production [PDF]

Hai‐Quan Mao, Jia-You Lin, Yizong Hu, Turash H. Pial, Ke Ding, Di Yu, Marine Guise, Paetra Brailsford, Maria Choi-Ali, Sixuan Li, Yining Zhu, Jingyao Ma, Leonardo Cheng, Xiaoya Lu, Nicole Korinetz, Tza‐Huei Wang, Tine Curk   +16 more
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Improved Recombinant Adeno-Associated Viral Vector Production via Molecular Evolution of the Viral Rep Protein. [PDF]

Int J Mol Sci
Steininger T, Öttl V, Franken LE, Frank C, Ohland P, Lopez Ferreiro M, Klostermann S, Fritsch J, Hirschauer E, Sandmeir A, Hilgenfeld LD, Semmelmann F, Dürr MS, Konkel F, Pechmann G, Linder S, Haindl M, Yazicioglu MN, Ringler P, Lauer ME, Phichith D, Seeber S, Fakhiri J.   +22 more
europepmc   +1 more source

In vitro cellular immune response to measles viral glycoproteins: role of the antigen vector.

, 1987
O Bakouche, Bruno Mougin, Denis Gerlier
openalex   +1 more source

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

, 2008
Zhong Li, Baozheng Li, Giridhararao Jayandharan, Cathryn Mah, L. Govindasamy, Mavis Agbandje‐McKenna, Roland W. Herzog, Kirsten A. Weigel-Van Aken, Jacqueline A. Hobbs, Sergei Zolotukhin, Nicholas Muzyczka, Arun Srivastava   +11 more
openalex   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery. [PDF]

Nanomaterials (Basel)
Leach M, Edmonds K, Ingram E, Dutch R, Wickramasinghe R, Chwatko M, Bhattacharyya D.   +6 more
europepmc   +1 more source