Results 271 to 280 of about 2,747,170 (398)

Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery. [PDF]

Nanomaterials (Basel)
Leach M, Edmonds K, Ingram E, Dutch R, Wickramasinghe R, Chwatko M, Bhattacharyya D.   +6 more
europepmc   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

660 Production of Therapeutic Proteins in Transgenic Plants and Viral Vectors

, 2000
John Hammond
openalex   +1 more source

Humoral Immune Response to Recombinant Adenovirus and Adeno-Associated Virus after In Utero Administration of Viral Vectors in Mice [PDF]

, 2002
Marina Jerebtsova, Mark L. Batshaw, Xuehai Ye   +2 more
openalex   +1 more source

Scalable control of stem cell fate by riboswitch-regulated RNA viral vector without genomic integration. [PDF]

Mol Ther
Kim N, Yokobayashi Y.
europepmc   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Therapeutic Liabilities of in Vivo Viral Vector Tropism: Adeno-Associated Virus Vectors, NMDAR1 Antisense, and Focal Seizure Sensitivity [PDF]

, 2002
Rebecca P. Haberman, Hugh E. Criswell, Stephen Snowdy, Zhen Ming, George R. Breese, R. Jude Samulski, Thomas J. McCown   +6 more
openalex   +1 more source

Safety comparison of mRNA, viral vector, and inactivated Covid-19 vaccines: incidence of adverse events following primary and booster doses among medical professionals in Malaysia. [PDF]

BMC Infect Dis
Prabhu R, Prabhu G, Htay MNN, Thundakattil AV, Moe S, Das S.   +5 more
europepmc   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

A breath of fresh air: targeted non-viral in vivo gene correction in the mammalian lung

Signal Transduction and Targeted Therapy
Jixin Liu, Dirk Grimm
doaj   +1 more source