Results 21 to 30 of about 2,747,170 (398)
Engineering multiple levels of specificity in an RNA viral vector [PDF]
, 2020 Synthetic molecular circuits could provide powerful therapeutic capabilities, but delivering them to specific cell types and controlling them remains challenging.
Chong, Lucy S. +4 more
core +1 more source
Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
Vaccines, 2021 Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently
Jean Carlos dos Santos da Luz +5 more
doaj +1 more source
Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design
Biomedicines, 2021 Various vaccinia virus (VACV) strains were applied during the smallpox vaccination campaign to eradicate the variola virus worldwide. After the eradication of smallpox, VACV gained popularity as a viral vector thanks to increasing innovations in genetic ...
Onur Kaynarcalidan +2 more
semanticscholar +1 more source
Type I Interferon Promotes Humoral Immunity in Viral Vector Vaccination
Journal of Virology, 2021 Viral vectors, including MVA, are an important antigen delivery platform and have been commonly used in vaccine development. Understanding the innate host-viral vector interactions and their impact on vaccine-induced immunity is critical but understudied.
Chaojie Zhong +10 more
semanticscholar +1 more source
Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR
Pathogens, 2022 In 2012–2013, chikungunya virus (CHIKV) was the cause of a major outbreak in the southern part of Lao People’s Democratic Republic (Lao PDR). Since then, only a few imported cases, with isolates belonging to different lineages, were recorded between 2014
Elodie Calvez +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, arose at the end of 2019 as a zoonotic virus, which is the causative agent of the novel coronavirus outbreak COVID-19. Without any clear indications of abatement, the disease has become a major
Rajashri Bezbaruah +7 more
semanticscholar +1 more source
Engineering influenza viral vectors [PDF]
Bioengineered, 2013 The influenza virus is a respiratory pathogen with a negative-sense, segmented RNA genome. Construction of recombinant influenza viruses in the laboratory was reported starting in the 1980s. Within a short period of time, pioneer researchers had devised methods that made it possible to construct influenza viral vectors from cDNA plasmid systems. Herein,
Mingtao Zeng +2 more
openaire +3 more sources
Журнал микробиологии, эпидемиологии и иммунобиологии, 2022 Despite the improvement of the obstetric care system, purulent-septic infections (PSI) of puerperas and the associated maternal mortality do not lose relevance at the present time.
S. S. Smirnova +2 more
doaj +1 more source
Vaccines, 2021 Viral vectors and viral vaccines are invaluable tools in prevention and treatment of diseases. Many infectious diseases are controlled using vaccines designed from subunits or whole viral structures, whereas other genetic diseases and cancers are being ...
Aline Do Minh, A. Kamen
semanticscholar +1 more source
Applied biosafety : journal of the American Biological Safety Association, 2020 Introduction: National Institutes of Health (NIH) defines gene therapy as an experimental technique that uses genes to treat or prevent disease. Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders,
Sumit Ghosh +3 more
semanticscholar +1 more source