Results 291 to 300 of about 2,747,170 (398)

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Goody two plasmids: An optimized transient transfection system for AAV vector production

Molecular Therapy: Methods & Clinical Development, 2023
Sergio David Moreno Velasquez, Emma Gerstmann, Dirk Grimm   +2 more
doaj  

Induction of Adult-like Antibody, Th1, and CTL Responses to Measles Hemagglutinin by Early Life Murine Immunization with An Attenuated Vaccinia-Derived NYVAC(K1L) Viral Vector

, 2001
Jiří Kovařík, Muriel Gaillard, Xavier Martínez, Paola Bozzotti, Paul‐Henri Lambert, Thorsten Wild, C.-A. Siegrist   +6 more
openalex   +1 more source

204. Quantitative Assessment of Cell Growth Reagents for Quality Control Purposes in a Good Manufacturing Practice Facility for Viral Gene Therapy Vector Production [PDF]

, 2002

openalex   +1 more source

Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs. [PDF]

Nucleic Acids Res
Li Z, Wang X, Janssen JM, Liu J, Tasca F, Hoeben RC, Gonçalves MAFV.   +6 more
europepmc   +1 more source

Systemic delivery of IL‐27 by an adeno‐associated viral vector inhibits T cell‐mediated colitis and induces multiple inhibitory pathways in T cells

Journal of Leukocyte Biology, 2016
Xiaotong Zhu, Zhihao Liu, Jin-qing Liu, Jianmin Zhu, Jianchao Zhang, Jonathan P. Davis, J. Chu, Jianhua Yu, Jie Zhou, Mingsong Li, X. Bai   +10 more
semanticscholar   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Generation of an artificially attenuated fowl adenovirus 4 viral vector using the reverse genetics system based on full-length infectious clone. [PDF]

Vet Res
Tang Z, Feng D, Fan W, Yan L, Song S.
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Long-term inhibition of Hepatitis B virus gene expression by a primary microrna expressing ancestral adeno-associated viral vector. [PDF]

Virol J
Mnyandu NZ, Limani SW, Ely A, Wadee R, Arbuthnot P, Maepa MB.   +5 more
europepmc   +1 more source