Results 61 to 70 of about 90,448 (261)

Virome Analysis and Association of Positive Coxsackievirus B Serology during Pregnancy with Congenital Heart Disease

Microorganisms, 2023
Background: We have previously shown coxsackievirus B (CVB) to be a potent inducer of congenital heart disease (CHD) in mice. The clinical relevance of these findings in humans and the roles of other viruses in the pathogenesis of CHD remain unknown ...
Mathieu Garand, Susie S. Y. Huang, Lisa S. Goessling, Fei Wan, Donna A. Santillan, Mark K. Santillan, Anoop Brar, Todd N. Wylie, Kristine M. Wylie, Pirooz Eghtesady   +9 more
doaj   +1 more source

3BNC117 a Broadly Neutralizing Antibody Suppresses Viremia in HIV-1-Infected Humans

Nature, 2015
HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was therefore abandoned.
M. Caskey, F. Klein, J. C. Lorenzi, M. Seaman, A. West, Noreen Buckley, G. Kremer, Lilian Nogueira, Malte Braunschweig, J. Scheid, J. Horwitz, I. Shimeliovich, Sivan Ben Avraham-Shulman, M. Witmer-Pack, M. Platten, C. Lehmann, L. Burke, T. Hawthorne, R. Gorelick, B. Walker, T. Keler, R. Gulick, G. Fätkenheuer, S. Schlesinger, M. Nussenzweig   +24 more
semanticscholar   +1 more source

Improving Linkage to the HCV Care Cascade in Nonspecialist Settings: Evaluation of the Performance and Triage Utility of the Elecsys HCV Duo Assay in Japan

Journal of Clinical Laboratory Analysis, EarlyView.
In nonspecialist departments, most anti‐HCV–positive individuals do not proceed to RNA testing. The Elecsys HCV Duo assay simultaneously detects anti‐HCV antibodies and core antigen from a single blood draw and preferentially identifies patients with clinically meaningful viral loads.
Hiroko Setoyama, Takehisa Watanabe, Shiho Miyase, Masakuni Tateyama, Motohiko Tanaka, Nobuhiro Minami, Masato Sasaki, Shunpei Hashigo, Kotaro Fukubayashi, Shotaro Ishii, Mutsuo Koga, Ryo Ichikawa, Hirofumi Iwashita, Yoshinari Sakai, Toshihiko Motohara, Kohei Tomita, Akinori Nakata, Yutaka Kai, Takeyasu Kounoe, Katsuki Haraoka, Takako Inoue, Takanori Suzuki, Kentaro Matsuura, Yasuhito Tanaka   +23 more
wiley   +1 more source

A Pilot Study of the Humoral Response Against the AntiSense Protein (ASP) in HIV-1-Infected Patients

Frontiers in Microbiology, 2020
The existence of an antisense Open Reading Frame (ORF) that encodes a putative AntiSense Protein (ASP) on the proviral genome of Human Immunodeficiency Virus type 1 (HIV-1) was a source of debate for 30 years.
Juliette Savoret, Nathalie Chazal, Jean-Pierre Moles, Edouard Tuaillon, Faroudy Boufassa, Laurence Meyer, Camille Lecuroux, Olivier Lambotte, Olivier Lambotte, Philippe Van De Perre, Jean-Michel Mesnard, Antoine Gross   +11 more
doaj   +1 more source

Differences in Humoral Immune Response against the Type 2 Porcine Reproductive and Respiratory Syndrome Virus via Different Immune Pathways

Viruses, 2022
The intramuscular vaccine is the principal strategy to protect pigs from porcine reproductive and respiratory syndrome virus (PRRSV), However, it is still difficult to control PRRSV effectively.
Wen Li, Yangyang Sun, Shijie Zhao, Zhiying Cui, Yu Chen, Pengli Xu, Jing Chen, Yina Zhang, Pingan Xia   +8 more
doaj   +1 more source

Successful treatment of vertically acquired Hepatitis C in a child using direct‐acting antiviral therapy administered via gastrojejunal tube: A case report

JPGN Reports, EarlyView.
Abstract Hepatitis C virus (HCV) remains a significant global health burden, with vertical transmission being the primary route of infection in children. Direct‐acting antivirals (DAAs) have transformed HCV treatment in pediatrics, but limited data exist on their administration in medically complex children who are dependent on enteral tubes. We report
Connie Chen, Leah Gibson, James Squires
wiley   +1 more source

Oral Inoculation of Specific-Pathogen-Free Chickens with Chicken Anemia Virus Induces Dose-Dependent Viremia and Transient Anemia

Pathogens, 2019
Chicken infectious anemia caused by chicken anemia virus (CAV) is a very important immunosuppressive disease in chickens. The horizontal spread of CAV in field chickens has been confirmed mainly through oral infection in our published article.
Suttitas Tongkamsai, Meng-Shiou Lee, Yi-Lun Tsai, Hsyang-Hsun Chung, Guan-Hua Lai, Jai-Hong Cheng, Ming-Chu Cheng, Yi-Yang Lien   +7 more
doaj   +1 more source

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation

Viruses, 2022
BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.
Olga Mineeva-Sangwo, Joan Martí-Carreras, Evert Cleenders, Dirk Kuypers, Piet Maes, Graciela Andrei, Maarten Naesens, Robert Snoeck   +7 more
doaj   +1 more source

Predictive value of tenofovir diphosphate in dried blood spots for future viremia in persons living with HIV.

Journal of Infectious Diseases, 2019
BACKGROUND Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is associated with viral suppression in persons living with HIV (PLWH) taking tenofovir disoproxil fumarate (TDF). However, its value as a predictor of future viremia remains unknown.
Mary Morrow, S. MaWhinney, Ryan P Coyle, Stacey S. Coleman, E. Gardner, Jia-Hua Zheng, L. Ellison, Lane R. Bushman, J. Kiser, P. Anderson, J. Castillo-Mancilla   +10 more
semanticscholar   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source