Results 41 to 50 of about 65,777 (239)
Medical Laboratory Journal, 2020 Background and Objectives: Human parvovirus B19 (B19V) is a widespread virus with various manifestations depending on the immunologic and hematologic status of the host.
Idris Nasir Abdullahi +9 more
doaj
Advances and perspectives in animal models of human hepatitis A virus
Animal Models and Experimental Medicine, EarlyView.Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li +3 more
wiley +1 more source
Microorganisms, 2023 Background: We have previously shown coxsackievirus B (CVB) to be a potent inducer of congenital heart disease (CHD) in mice. The clinical relevance of these findings in humans and the roles of other viruses in the pathogenesis of CHD remain unknown ...
Mathieu Garand +9 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li +11 more
wiley +1 more source
Pathogens, 2019 Chicken infectious anemia caused by chicken anemia virus (CAV) is a very important immunosuppressive disease in chickens. The horizontal spread of CAV in field chickens has been confirmed mainly through oral infection in our published article.
Suttitas Tongkamsai +7 more
doaj +1 more source
A Pilot Study of the Humoral Response Against the AntiSense Protein (ASP) in HIV-1-Infected Patients
Frontiers in Microbiology, 2020 The existence of an antisense Open Reading Frame (ORF) that encodes a putative AntiSense Protein (ASP) on the proviral genome of Human Immunodeficiency Virus type 1 (HIV-1) was a source of debate for 30 years.
Juliette Savoret +11 more
doaj +1 more source
Viruses, 2022 The intramuscular vaccine is the principal strategy to protect pigs from porcine reproductive and respiratory syndrome virus (PRRSV), However, it is still difficult to control PRRSV effectively.
Wen Li +8 more
doaj +1 more source
Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action
Clinical Pharmacology &Therapeutics, EarlyView.Bemnifosbuvir (BEM) is a potent, pan‐genotypic inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. Its antiviral activity was evaluated in an ascending dose phase I clinical trial involving 30 patients treated once a day for 7 days. After treatment initiation, plasma HCV RNA declined in a biphasic manner with a mean reduction of 2.3 log10 ...
Carolin Zitzmann +4 more
wiley +1 more source
Viruses, 2022 BK polyomavirus (BKPyV) is a human DNA virus generally divided into twelve subgroups based on the genetic diversity of Viral Protein 1 (VP1). BKPyV can cause polyomavirus-associated nephropathy (PVAN) after kidney transplantation.
Olga Mineeva-Sangwo +7 more
doaj +1 more source
Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys
Equine Veterinary Journal, EarlyView.Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé +5 more
wiley +1 more source