Results 201 to 210 of about 104,970 (255)

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Interferon-induced transmembrane proteins in cancer and virus biology: a membrane perspective. [PDF]

mBio
Xia T, Cimarelli A.
europepmc   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source

Bioorthogonal click-chemistry labeling and visualization of dual noncanonical amino acid-incorporated HIV-1 Env on intact virions. [PDF]

Methods Enzymol
Gonepudi NK, Xu W, Awuah HB, Lu M.
europepmc   +1 more source

Nanoscopy reveals heparan sulfate clusters as docking sites for SARS-CoV-2 attachment and entry. [PDF]

Elife
Han S, Wang X, Li T, Mohseni A, Kosik I, Chan CY, López-Muñoz AD, Matthias J, Suddaby R, Wang Z, Jin AJ, Wurm CA, Yewdell JW, Wu LG.   +13 more
europepmc   +1 more source

Comparative Genomic Analysis of Two Bat Poxviruses in the Genus <i>Vespertilionpoxvirus</i>. [PDF]

Viruses
Zhang C, Heye K, Lelli D, Tazi L, Rothenburg S.   +4 more
europepmc   +1 more source

PIM1 and PIM3 Kinases Suppress HIV-1 Protein Expression and Particle Production Through Distinct Roles. [PDF]

Pathogens
Tran KQ, Le BQ, Koma T, Doi N, Kondo T, Komoda N, Udagawa M, Okumura N, Gotoda C, Nagasaka M, Ichinomiya T, Inamoto Y, Adachi A, Nomaguchi M.   +13 more
europepmc   +1 more source

Beyond assembly: functions of the coronavirus M protein. [PDF]

Virol J
Kariuki CK, Doijen J, Mann MK, Xie J, Van Loock M, Van Damme E.   +5 more
europepmc   +1 more source

H1N1 seasonal surge in India, 2026: Emerging public health threat and evidence based preventive strategies. [PDF]

New Microbes New Infect
Choudhary OP, Choudhary P.
europepmc   +1 more source

Scavenger Receptor Class F Member 2: An Intracellular Receptor Escorting Hepatitis B Virus From Endosome to Nuclear Pore

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
Yujing Ng, Lin Du, Huahao Fan
wiley   +1 more source