Results 21 to 30 of about 102,321 (242)

MORPHOLOGICAL ANALYSIS OF HEPATITIS B VIRUS WITH ESCAPE MUTATIONS IN S-gene G145R AND S143L

Вопросы вирусологии, 2017
Background. In terms of serological properties and immunization, the wild type of HBsAg HBV and its G145R mutant behave as different antigens. This testifies to serious structural changes, which presumably could have a significant impact on the ...
M. V. Konopleva, M. V. Sokolova, N. V. Shevlyagina, A. I. Bazhenov, A. A. Fel’Dsherova, M. A. Krymskij, V. N. Borisova, T. A. Semenenko, V. G. Nesterenko, A. P. Suslov   +9 more
doaj   +1 more source

A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion

Journal of Biomedical Science, 2021
Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA.
Chih-Hsu Chang, Shu-Fan Chou, Chiaho Shih   +2 more
doaj   +1 more source

Purification and Proteomics of Influenza Virions [PDF]

, 2018
This chapter describes a basic workflow for analyzing the protein composition of influenza virions. In order to obtain suitable material, the chapter describes how to concentrate influenza virions from the growth media of infected cells and to purify them by ultracentrifugation through a density gradient.
Hutchinson, Edward C., Stegmann, Monika
openaire   +2 more sources

Identification of the ¹⁵FRFG domain in HIV-1 Gag p6 essential for Vpr packaging into the virion

Retrovirology, 2004
The auxiliary regulatory protein Vpr of HIV-1 is packaged in the virion through interaction with the Gag C-terminal p6 domain. Virion packaging of Vpr is critical for Vpr to exert functions in the HIV-1 life cycle.
Zhu Henghu, Jian Heng, Zhao Ling-Jun
doaj   +1 more source

Intravirion DNA Can Access the Space Occupied by the Bacteriophage P22 Ejection Proteins

Viruses, 2021
Tailed double-stranded DNA bacteriophages inject some proteins with their dsDNA during infection. Phage P22 injects about 12, 12, and 30 molecules of the proteins encoded by genes 7, 16 and 20, respectively.
Justin C. Leavitt, Eddie B. Gilcrease, Brianna M. Woodbury, Carolyn M. Teschke, Sherwood R. Casjens   +4 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Zika Virus NS2A-Mediated Virion Assembly

mBio, 2019
The flavivirus virion consists of an envelope outer layer, formed by envelope (E) and membrane (M) proteins on a lipid bilayer, and an internal core, formed by capsid (C) protein and genomic RNA. The molecular mechanism of flavivirus assembly is not well
Xianwen Zhang, Xuping Xie, Hongjie Xia, Jing Zou, Linfen Huang, Vsevolod L. Popov, Xinwen Chen, Pei-Yong Shi   +7 more
doaj   +1 more source

Vaccinia Virus A6 Is Essential for Virion Membrane Biogenesis and Localization of Virion Membrane Proteins to Sites of Virion Assembly [PDF]

Journal of Virology, 2012
ABSTRACT Poxvirus acquires its primary envelope through a process that is distinct from those of other enveloped viruses. The molecular mechanism of this process is poorly understood, but several poxvirus proteins essential for the process have been identified in studies of vaccinia virus (VACV), the prototypical poxvirus ...
Xiangzhi, Meng, Addie, Embry, Lloyd, Rose, Bo, Yan, Chungui, Xu, Yan, Xiang   +5 more
openaire   +2 more sources

Endonucleases and simian virus 40 virions: origin of a virion-associated endonuclease [PDF]

Journal of Virology, 1976
The origin and role of the endonuclease activity associated with purified virions of simian virus 40, previously described by this and other laboratories, have been further investigated. We found that the enzymatic activity from virions of temperature-sensitive (ts) mutants is not more heat labile than that from wild-type virions.
D C, Dooley, M T, Ryzlak, H L, Ozer
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source