Results 21 to 30 of about 104,970 (255)

HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

open access: yesViruses, 2013
The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck. However, the implication of this interaction for viral replication and infectivity in macrophages and T lymphocytes remains ...
Gilda Tachedjian   +3 more
doaj   +1 more source

Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating.

open access: yesPLoS Pathogens, 2021
The hemagglutinin (HA) surface glycoprotein is triggered by endosomal low pH to cause membrane fusion during influenza A virus (IAV) entry yet must remain sufficiently stable to avoid premature activation during virion transit between cells and hosts. HA
Guohua Yang   +2 more
doaj   +1 more source

HUMAN PARVOVIRUS В19: VIRUS CHARACTERISTICS, DISTRIBUTION AND DIAGNOSTICS OF PARVOVIRUS INFECTION

open access: yesИнфекция и иммунитет, 2014
. The modern data about morphology as well as structural and functional organization of the parvovirus B19 genome, circulating virus genotypes are presented in the review.
I. N. Lavrentyeva, A. Y. Antipova
doaj   +1 more source

Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. [PDF]

open access: yesPLoS ONE, 2011
Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope.
Aaron To   +6 more
doaj   +1 more source

MORPHOLOGICAL ANALYSIS OF HEPATITIS B VIRUS WITH ESCAPE MUTATIONS IN S-gene G145R AND S143L

open access: yesВопросы вирусологии, 2017
Background. In terms of serological properties and immunization, the wild type of HBsAg HBV and its G145R mutant behave as different antigens. This testifies to serious structural changes, which presumably could have a significant impact on the ...
M. V. Konopleva   +9 more
doaj   +1 more source

A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion

open access: yesJournal of Biomedical Science, 2021
Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA.
Chih-Hsu Chang   +2 more
doaj   +1 more source

Purification and Proteomics of Influenza Virions [PDF]

open access: yes, 2018
This chapter describes a basic workflow for analyzing the protein composition of influenza virions. In order to obtain suitable material, the chapter describes how to concentrate influenza virions from the growth media of infected cells and to purify them by ultracentrifugation through a density gradient.
Hutchinson, Edward C., Stegmann, Monika
openaire   +2 more sources

Human Cytomegalovirus Primary Infection and Reactivation: Insights From Virion-Carried Molecules

open access: yesFrontiers in Microbiology, 2020
Human cytomegalovirus (HCMV), a ubiquitous beta-herpesvirus, is able to establish lifelong latency after initial infection. Periodical reactivation occurs after immunosuppression, remaining a major cause of death in immunocompromised patients.
Yu-Qing Wang   +2 more
doaj   +1 more source

Identification of the 15FRFG domain in HIV-1 Gag p6 essential for Vpr packaging into the virion

open access: yesRetrovirology, 2004
The auxiliary regulatory protein Vpr of HIV-1 is packaged in the virion through interaction with the Gag C-terminal p6 domain. Virion packaging of Vpr is critical for Vpr to exert functions in the HIV-1 life cycle.
Zhu Henghu, Jian Heng, Zhao Ling-Jun
doaj   +1 more source

Intravirion DNA Can Access the Space Occupied by the Bacteriophage P22 Ejection Proteins

open access: yesViruses, 2021
Tailed double-stranded DNA bacteriophages inject some proteins with their dsDNA during infection. Phage P22 injects about 12, 12, and 30 molecules of the proteins encoded by genes 7, 16 and 20, respectively.
Justin C. Leavitt   +4 more
doaj   +1 more source

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