Results 31 to 40 of about 22,731 (252)

Detecting virological failure in HIV-infected Tanzanian children

South African Medical Journal, 2014
The performance of clinical and immunological criteria to predict virological failure in HIV-infected children receiving antiretroviral therapy (ART) is not well documented.To determine the validity of clinical and immunological monitoring in detecting virological failure in children on ART.A total of 218 children were included in the study.
Mgelea, E M, Kisenge, R, Aboud, S
openaire   +5 more sources

Virological failure and associated factors among children receiving anti-retroviral therapy, Northwest Ethiopia.

PLoS ONE, 2021
BackgroundVirological failure is under-recognized issue among children living with human immunodeficiency virus in developing countries. This partly may lead to failure to achieve the global goal of 90-90-90 targets in most developing countries including
Biruk Bayleyegn, Zemene Demelash Kifle, Demeke Geremew   +2 more
doaj   +1 more source

Correlation of HIV-1 drug resistant mutations and virologic failure

Pan African Medical Journal, 2021
mutations are important by ensuring that the HIV-1 agent remains fit in the environment and evades drugs that are developed purposely to kill them. In Kenya, mutations conferring resistance to available ARVs have been reported in previous studies. However, there is a paucity of information on whether these previous studies have reported all mutations ...
Olipher Makwaga, David Hughes Mulama, John Muoma, Matilu Mwau   +3 more
openaire   +3 more sources

Long-Term Outcome of an HIV-Treatment Programme in Rural Africa: Viral Suppression despite Early Mortality

AIDS Research and Treatment, 2011
Objective. To define the long-term (2–4 years) clinical and virological outcome of an antiretroviral treatment (ART) programme in rural South Africa. Methods.
Roos E. Barth, Hugo A. Tempelman, Robert Moraba, Andy I. M. Hoepelman   +3 more
doaj   +1 more source

Magnitude and correlates of virological failure among adult HIV patients receiving PI based second line ART regimens in north western Tanzania; a case control study

BMC Infectious Diseases, 2019
Background With a growing access to free ART, switching of ART to second line regimen has also become common following failure of first line ART regimens.
Daniel W. Gunda, Semvua B. Kilonzo, Tarcisius Mtaki, Desderius M. Bernard, Samwel E. Kalluvya, Elichilia R. Shao   +5 more
doaj   +1 more source

Incidence and predictors of virological failure among HIV infected children and adolescents on first-line antiretroviral therapy in East Shewa hospitals, Oromia Region, Ethiopia: A retrospective follow up study.

PLoS ONE, 2023
IntroductionDespite gains made from improved antiretroviral therapy coverage in resource limited countries, the occurrence of first line drug resistance remains a priority agenda.
Netsanet Melkamu Abera, Tewodros Getaneh Alemu, Chilot Desta Agegnehu   +2 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

A cross-sectional study to evaluate second line virological failure and elevated bilirubin as a surrogate for adherence to atazanavir/ritonavir in two urban HIV clinics in Lilongwe, Malawi

BMC Infectious Diseases, 2017
Background Malawi’s national antiretroviral therapy program provides atazanavir/ritonavir–based second line regimens which cause concentration-dependent rise in indirect bilirubin.
Dennis Miyoge Ongubo, Robertino Lim, Hannock Tweya, Christopher Chikhosi Stanley, Petros Tembo, Richard Broadhurst, Salem Gugsa, McNeil Ngongondo, Colin Speight, Tom Heller, Sam Phiri, Mina C. Hosseinipour   +11 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Second-line virologic failure and elevated bilirubin as a potential surrogate marker of ART adherence among people living with HIV in Eastern Uganda

AIDS Research and Therapy
Second-line antiretroviral therapy (ART) failure remains a challenge in HIV Programs. We conducted a cross-sectional study among people living with HIV on second-line ART in Eastern Uganda to determine the prevalence and associated factors of virological
Simiyu Melap Lynnet, Jacob Stanley Iramiot, Rebecca Nekaka, Patrick Okware, Mary Abwola Olwedo, Joshua Epuitai, Paul Oboth, Herbert Itabangi, Lydia V. N. Ssenyonga, Julius Nteziyaremye, David Okia   +10 more
doaj   +1 more source