Results 51 to 60 of about 22,731 (252)

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Italian Journal of Pediatrics, 2021
Background Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and
Belete Gelaw, Getasew Mulatu, Getasew Tesfa, Chalie Marew, Bogale Chekole, Animut Alebel   +5 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Leveraging corona virus disease 2019 vaccination to promote hepatitis C screening

Hepatology Communications, EarlyView., 2022
Abstract Health care initiatives, such as hepatitis C virus (HCV) screening, have been greatly overshadowed by the corona virus disease 2019 (COVID‐19) pandemic. However, COVID‐19 vaccination programs also provide an opportunity to engage with a high volume of people in a health care setting.
Aaron Vanderhoff, David Smookler, Mia J. Biondi, Scott Enman, Tintin Fuliang, Sana Mahmood, Agustina Crespi, Maria Marquez, Rafique Van Uum, Lucy You, Brett Wolfson‐Stofko, Renee Logan, Erin LeDrew, Hemant Shah, Harry Janssen, Camelia Capraru, Elisa Venier, Jordan J. Feld   +17 more
wiley   +1 more source

Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting

BMC Infectious Diseases, 2008
Background Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alternative monitoring strategy has not
Lawn Stephen D, Badri Motasim, Wood Robin   +2 more
doaj   +1 more source

Molecular transmission network of pretreatment drug resistance among human immunodeficiency virus-positive individuals and the impact of virological failure on those who received antiretroviral therapy in China

Frontiers in Medicine, 2022
ObjectivesWe investigated the prevalence of pretreatment drug resistance (PDR), the molecular transmission network among HIV-positive individuals, and the impact of virological failure on those who received antiretroviral therapy (ART) in China ...
Hongli Chen, Jing Hu, Chang Song, Miaomiao Li, Yesheng Zhou, Aobo Dong, Ruihua Kang, Jingjing Hao, Jiaxin Zhang, Xiu Liu, Dan Li, Yi Feng, Lingjie Liao, Yuhua Ruan, Hui Xing, Yiming Shao   +15 more
doaj   +1 more source

Virological failure to raltegravir in Spain: incidence, prevalence and clinical consequences

Journal of Antimicrobial Chemotherapy, 2015
The objective of this study was to evaluate the incidence, prevalence and clinical consequences of virological failure (VF) to raltegravir-based regimens in Spain.A multicentre, retrospective, observational study was performed in 10 tertiary hospitals (January 2006 to June 2013).
Santos, José R., Blanco, José Luis, Masiá, Mar, Gutiérrez, Félix, Pérez-Elías, María Jesús, Iribarren, José Antonio, Force, Lluis, Antela, Antonio, Knobel, Hernando, Salavert, Miquel, López Bernaldo de Quirós, Juan Carlos, Pino, Maria, Paredes, Roger, Clotet, Bonaventura   +13 more
openaire   +6 more sources

Switching to an etravirine regimen in virologically suppressed patients with previous virological failures and presence of resistance mutations [PDF]

Journal of the International AIDS Society, 2012
BackgroundSimplification of antiretroviral therapy (ART) may be an option for virologically suppressed patients for a variety of reasons. Etravirine (ETV) 400 mg qd has a good safety profile and retains activity against viruses resistant to nevirapine or efavirenz.
J Blanco, J Casado, A González‐Cordón, E Martinez, M del Palacio, P Domingo, J Mallolas, M Mateo, M Pérez Elías, I Pérez, M Gutiérrez, J Gatell   +11 more
openaire   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Viral failure and associated factors in adults on second line antiretroviral therapy in public hospitals of Harari Region and Dire Dawa administration, Eastern Ethiopia

Journal of Public Health Research
Background: Virological failure in second-line antiretroviral therapy (ART) occurs when HIV patients have a viral load exceeding 1000 copies/ml, presenting significant public health challenges, including increased risk of transmission of HIV, heightened ...
Lemid Mustefa, Kirubel Minsamo, Alemayehu Deressa, Dawit Firdisa, Shiferaw Letta   +4 more
doaj   +1 more source

Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil

Brazilian Journal of Infectious Diseases, 2017
Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS.
Monaliza Cardozo Rebouças, Márcio Oliveira da Silva, Tatiana Haguihara, Carlos Brites, Eduardo Martins Netto   +4 more
doaj   +1 more source