Results 61 to 70 of about 1,729,369 (285)

Plasma CD4 Count and Duration ARV as a Predictor of Virological Failure Amongst AIDS Patients [PDF]

, 2021
Background: The 90-90-90 strategy to overcome the HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome) epidemic in the world still has challenges because 20% of people live with HIV/AIDS (PLWHA) received anti retroviral (ARVs) are ...
Musofa Rusli, -, Erwin Astha Triyono, -, Choirina Windradi, -   +2 more
core   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study

BMC Infectious Diseases, 2020
Background Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virological failure on antiretroviral therapy (ART) is serious in this area.
Dan Yuan, Meijing Liu, Peng Jia, Yiping Li, Yuling Huang, Li Ye, Laze Api, Maogang Chen, Liang Yao, Zixin Wang, Honglu Liu, Shu Liang, Shujuan Yang   +12 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Multicenter study in Turkiye of unsuppressed viremia in people living with human immunodeficiency virus: aegean experience

BMC Infectious Diseases
Introduction/Objective This Turkish study aimed to investigate the factors that contribute to the failure of virological suppression in people with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART).
Ilkay Akbulut, Zeynep Sedef Varol, Veysel Akca, Basak Gol Serin, Emel Erogul, Ilker Odemiş, Seniha Senbayrak, Sabri Atalay   +7 more
doaj   +1 more source

Predictors of Virological Failure in HIV Patients Receiving First Line Antiretroviral Therapy with Good Adherence

Jurnal Penyakit Dalam Indonesia, 2017
Introduction. Antiretroviral therapy (ART) effectively suppress HIV replication. Viral load (VL) measurement is better predictor than clinical or immunological criteria to evaluate success or failure of ART.
Farid Kurniawan, Samsuridjal Djauzi, Evy Yunihastuti, Pringgodigdo Nugroho   +3 more
doaj   +1 more source

Subgroup analysis on treatment, virological, and immunological failure prevalence.

, 2023
Subgroup analysis on treatment, virological, and immunological failure prevalence.
Fangfang Chen (302428), Fan Lyu (15389245), Houlin Tang (573087), Yushan Hou (9111662), Decai Zhao (155378), Dandan Niu (584008), Hehe Zhao (13951842), Shi Wang (116703)   +7 more
core   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Risk factors for virological failure and subtherapeutic antiretroviral drug concentrations in HIV-positive adults treated in rural northwestern Uganda [PDF]

, 2009
: BACKGROUND: Little is known about immunovirological treatment outcomes and adherence in HIV/AIDS patients on antiretroviral therapy (ART) treated using a simplified management approach in rural areas of developing countries, or about the main factors ...
Pinoges Loretxu, Laurence Ahoua, Balkan, S, Marie-Laure Chaix, Anguzu Paul, Balkan Suna, Olson David, Olson, D, Olaro Charles, Pinoges, L, Le Tiec, C, Clotilde Le Tiec, Charles Olaro, Ahoua Laurence, Guenther Gunar, Gunar Guenther, Chaix Marie-Laure, Paul Anguzu, Pujades-Rodríguez Mar, Loretxu Pinoges, Anguzu, P, Mar Pujades-Rodríguez, Olaro, C, Guenther, G, Le Tiec Clotilde, Suna Balkan, David Olson, Chaix, M L, Pujades-Rodriguez, M, Ahoua, L   +29 more
core   +2 more sources