Results 61 to 70 of about 22,731 (252)

Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohort. [PDF]

PLoS ONE, 2010
OBJECTIVE: Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure. DESIGN: We
Nathan Ford, Marta Darder, Tim Spelman, Emi Maclean, Edward Mills, Andrew Boulle   +5 more
doaj   +1 more source

Clinical and Virological Aspects of HBV Reactivation: A Focus on Acute Liver Failure [PDF]

Viruses, 2019
Hepatitis B virus (HBV) reactivation in immunosuppressed patients can cause considerable morbidity and mortality. The aim of our study was to evaluate factors associated with acute liver failure (ALF) in HBV reactivation. Clinical, laboratory, and virological data of 87 patients with HBV reactivation were analyzed retrospectively.
Olympia E. Anastasiou, Martin Theissen, Jens Verheyen, Barbara Bleekmann, Heiner Wedemeyer, Marek Widera, Sandra Ciesek   +6 more
openaire   +5 more sources

Real‐Time and Non‐Invasive Detection of Respiratory Viral Infections Using an Intelligent Odor Monitoring System (IOMS)

Advanced Science, EarlyView.
An intelligent odor monitoring system integrates an IVC animal model, gas sensor array, real‐time resistance readout, and machine‐learning analysis to continuously monitor infection‐associated odor changes. The platform captures longitudinal sensor responses, distinguishes infected from healthy states, and supports early‐stage respiratory viral ...
Yajie Shen, Weifeng Yuan, Long Li, Yucheng Zheng, Kenan Liu, Hegeng Li, Hua‐Yao Li, Yongliang Zhao, Binzhou Ying, Lanpeng Guo, Wenjian Zhang, Shu‐Ming Kuo, Zirui Zhang, Yufan Deng, Bohan Yin, Zhaocheng Luo, Ke Xu, Huan Liu   +17 more
wiley   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Virological treatment failure and associated factors among adults on first-line antiretroviral therapy in West Hararghe, Ethiopia

Frontiers in Public Health
BackgroundVirological failure on first-line antiretroviral therapy (ART) remains a major challenge in the management of HIV/AIDS in resource-limited settings, including Ethiopia.
Ebisa Zerihun, Kenesa Tesema, Fekadu Abera   +2 more
doaj   +1 more source

Synergistic Physicochemical Inhibition of Reactive Shale Formations Using Hydrothermally Synthesized Hydroxyapatite Nickel Tungstate Nanocomposites in Water‐Based Drilling Fluids

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Wellbore instability driven by the volumetric expansion of reactive shale formations remains a primary operational challenge in modern drilling engineering, causing severe mechanical failures and substantial economic deficits. The objective of this study is to formulate and evaluate a novel dual‐action chemical additive capable of ...
Ghaleb Oriquat, Basim Abdul Alrhym, A. C. Umamaheshwer Rao, Shivam P. Chaudhary, Pardeep Singh Bains, Ripendeep Singh, Murotov Nurshod, Rasulbek Eshmetov, Ahmad Abumalek   +8 more
wiley   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Virologic failure and metabolic syndrome in patients with HIV infection [PDF]

Journal of the International AIDS Society, 2008
Methods This was a cross-sectional observational study that included all consecutive HIV-infected patients evaluated at the metabolic clinic of the University of Modena and Reggio Emilia, Italy, between January 2006 and January 2008 who had received antiretroviral therapy for at least 2 years. Lipodystrophy and metabolic syndrome were defined according
Nicola Squillace, Giovanni Guaraldi, Chiara Stentarelli, Giulia Nardini, Barbara Beghetto, Giovanna Orlando, Stefano Zona   +6 more
openaire   +2 more sources

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Prevalence and determinants of virologic failure among HIV patients on ART in Africa: A systematic review and meta-analysis

Virology Journal
Background The Joint United Nations Programme on HIV/AIDS (UNAIDS) has established the 95-95-95 targets, aiming that by 2030, 95% of individuals on ART will achieve viral suppression.
Ayanaw Dinku Abebe, Worku Chekol Tassew, Yeshiwas Ayale Ferede, Jember Ayelgne Beyene, Muluneh Assefa   +4 more
doaj   +1 more source