Results 71 to 80 of about 45,169 (292)

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]

, 2013
BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry, Alexandra Calmy, Anne-Marie Taburet, Avihingsanon, Blackwelder, Boulle, Carlota Silva, Chen, Christine Rouzioux, Christophe Michon, Cohen, Cohen, Davies, Dejesus, Dieterich, Elisabeth Baudin, Elizabete Nunes, Flandre, Ford, Gengiah, Gulick, Ilesh Jani, Kwara, Laura Ciaffi, Maartens, Manosuthi, Manosuthi, Maryline Bonnet, Matteelli, Mbuagbaw, Meintjes, Nilesh Bhatt, Rui Bastos, Scourfield, Shipton, Soriano, Swaminathan, Tang, Telenti, van Leth   +39 more
core   +3 more sources

Multicenter study in Turkiye of unsuppressed viremia in people living with human immunodeficiency virus: aegean experience

BMC Infectious Diseases
Introduction/Objective This Turkish study aimed to investigate the factors that contribute to the failure of virological suppression in people with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART).
Ilkay Akbulut, Zeynep Sedef Varol, Veysel Akca, Basak Gol Serin, Emel Erogul, Ilker Odemiş, Seniha Senbayrak, Sabri Atalay   +7 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Virological failure after 1 year of first-line ART is not associated with HIV minority drug resistance in rural Cameroon [PDF]

, 2017
Objectives The aim of this study was to describe clinical and virological outcomes in therapy-naive HIV-1-positive patients treated in a routine ART programme in rural Cameroon.
Awasom, C., Burchard, G. D., Campbell, N. K., Drexler, J. F., Feldt, T., Hammerl, R., Jochum, J., Metzner, K. J., Nassimi, N., Raymond, Y., Schmiedel, S., Taka, N., van Lunzen, J., Zoufaly, A.   +13 more
core  

Predictors of Virological Failure in HIV Patients Receiving First Line Antiretroviral Therapy with Good Adherence

Jurnal Penyakit Dalam Indonesia, 2017
Introduction. Antiretroviral therapy (ART) effectively suppress HIV replication. Viral load (VL) measurement is better predictor than clinical or immunological criteria to evaluate success or failure of ART.
Farid Kurniawan, Samsuridjal Djauzi, Evy Yunihastuti, Pringgodigdo Nugroho   +3 more
doaj   +1 more source

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Italian Journal of Pediatrics, 2021
Background Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and
Belete Gelaw, Getasew Mulatu, Getasew Tesfa, Chalie Marew, Bogale Chekole, Animut Alebel   +5 more
doaj   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil

Brazilian Journal of Infectious Diseases, 2017
Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS.
Monaliza Cardozo Rebouças, Márcio Oliveira da Silva, Tatiana Haguihara, Carlos Brites, Eduardo Martins Netto   +4 more
doaj   +1 more source

Molecular transmission network of pretreatment drug resistance among human immunodeficiency virus-positive individuals and the impact of virological failure on those who received antiretroviral therapy in China

Frontiers in Medicine, 2022
ObjectivesWe investigated the prevalence of pretreatment drug resistance (PDR), the molecular transmission network among HIV-positive individuals, and the impact of virological failure on those who received antiretroviral therapy (ART) in China ...
Hongli Chen, Jing Hu, Chang Song, Miaomiao Li, Yesheng Zhou, Aobo Dong, Ruihua Kang, Jingjing Hao, Jiaxin Zhang, Xiu Liu, Dan Li, Yi Feng, Lingjie Liao, Yuhua Ruan, Hui Xing, Yiming Shao   +15 more
doaj   +1 more source