Results 71 to 80 of about 1,729,369 (285)

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil

Brazilian Journal of Infectious Diseases, 2017
Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS.
Monaliza Cardozo Rebouças, Márcio Oliveira da Silva, Tatiana Haguihara, Carlos Brites, Eduardo Martins Netto   +4 more
doaj   +1 more source

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Italian Journal of Pediatrics, 2021
Background Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and
Belete Gelaw, Getasew Mulatu, Getasew Tesfa, Chalie Marew, Bogale Chekole, Animut Alebel   +5 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Viral failure and associated factors in adults on second line antiretroviral therapy in public hospitals of Harari Region and Dire Dawa administration, Eastern Ethiopia

Journal of Public Health Research
Background: Virological failure in second-line antiretroviral therapy (ART) occurs when HIV patients have a viral load exceeding 1000 copies/ml, presenting significant public health challenges, including increased risk of transmission of HIV, heightened ...
Lemid Mustefa, Kirubel Minsamo, Alemayehu Deressa, Dawit Firdisa, Shiferaw Letta   +4 more
doaj   +1 more source

Molecular transmission network of pretreatment drug resistance among human immunodeficiency virus-positive individuals and the impact of virological failure on those who received antiretroviral therapy in China

Frontiers in Medicine, 2022
ObjectivesWe investigated the prevalence of pretreatment drug resistance (PDR), the molecular transmission network among HIV-positive individuals, and the impact of virological failure on those who received antiretroviral therapy (ART) in China ...
Hongli Chen, Jing Hu, Chang Song, Miaomiao Li, Yesheng Zhou, Aobo Dong, Ruihua Kang, Jingjing Hao, Jiaxin Zhang, Xiu Liu, Dan Li, Yi Feng, Lingjie Liao, Yuhua Ruan, Hui Xing, Yiming Shao   +15 more
doaj   +1 more source

Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting

BMC Infectious Diseases, 2008
Background Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alternative monitoring strategy has not
Lawn Stephen D, Badri Motasim, Wood Robin   +2 more
doaj   +1 more source

Switching to an etravirine regimen in virologically suppressed patients with previous virological failures and presence of resistance mutations [PDF]

Journal of the International AIDS Society, 2012
BackgroundSimplification of antiretroviral therapy (ART) may be an option for virologically suppressed patients for a variety of reasons. Etravirine (ETV) 400 mg qd has a good safety profile and retains activity against viruses resistant to nevirapine or efavirenz.
J Blanco, J Casado, A González‐Cordón, E Martinez, M del Palacio, P Domingo, J Mallolas, M Mateo, M Pérez Elías, I Pérez, M Gutiérrez, J Gatell   +11 more
openaire   +1 more source

Significant predictors associated with virological failure and therapeutic failure.

, 2016
Significant predictors associated with virological failure and therapeutic failure.
Michèle Treger (3308376), Pierre-Marie Roger (774036), Firouze Bani-Sadr (432319), Pierre Gantner (2190394), Thomas Jovelin (3308373), David Rey (697350), Rodolphe Garraffo (3308370), Pascal Pugliese (816486)   +7 more
core   +1 more source

Virological treatment failure and associated factors among adults on first-line antiretroviral therapy in West Hararghe, Ethiopia

Frontiers in Public Health
BackgroundVirological failure on first-line antiretroviral therapy (ART) remains a major challenge in the management of HIV/AIDS in resource-limited settings, including Ethiopia.
Ebisa Zerihun, Kenesa Tesema, Fekadu Abera   +2 more
doaj   +1 more source