Results 31 to 40 of about 1,645 (202)
A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]
, 2018 Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI +5 more
core +2 more sources
Human cytomegalovirus: taking the strain [PDF]
, 2015 In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments.
Aicheler, Rebecca +11 more
core +3 more sources
Virome genomics: a tool for defining the human virome
Current Opinion in Microbiology, 2013 High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and ...
Wylie, Kristine M +2 more
openaire +2 more sources
Expanding standards in viromics: in silico evaluation of dsDNA viral genome identification, classification, and auxiliary metabolic gene curation [PDF]
PeerJ, 2021 Background Viruses influence global patterns of microbial diversity and nutrient cycles. Though viral metagenomics (viromics), specifically targeting dsDNA viruses, has been critical for revealing viral roles across diverse ecosystems, its analyses ...
Akbar Adjie Pratama +9 more
doaj +2 more sources
Diversity of dsDNA viruses in a South African hot spring assessed by metagenomics and microscopy [PDF]
, 2017 The current view of virus diversity in terrestrial hot springs is limited to a few sampling sites. To expand our current understanding of hot spring viral community diversity, this study aimed to investigate the first African hot spring (Brandvlei hot ...
Ackermann +4 more
core +2 more sources
The gut virome:the ‘missing link’ between gut bacteria and host immunity? [PDF]
, 2019 The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our well-being. Despite its predominance, the virome remains one of the least understood components of the
Carding, Simon R. +4 more
core +2 more sources
mSystems, 2021 To our knowledge, this is the first article to apply metagenomics to characterize changes in gut microbial population dynamics caused by a clinically relevant model of central nervous system (CNS) trauma.
Jingjie Du +5 more
doaj +1 more source
Speculations on the clinical significance of asymptomatic viral infections [PDF]
, 2016 A detailed understanding of asymptomatic chronic viral infections is critical to analyse their pathogenesis, assess the severity and burden of disease and, where required, optimize public health control measures.
Gentile, Giuseppe, Micozzi, Alessandra
core +1 more source
Virome Capture Sequencing Enables Sensitive Viral Diagnosis and Comprehensive Virome Analysis [PDF]
mBio, 2015 ABSTRACT Insensitivity and technical complexity have impeded the implementation of high-throughput nucleic acid sequencing in differential diagnosis of viral infections in clinical laboratories. Here, we describe the development of a virome capture sequencing platform for vertebrate viruses (VirCapSeq-VERT) that increases the sensitivity of ...
Thomas Briese +6 more
openaire +3 more sources
VIROME: Downloading libraries of VIROME data v1
, 2015 This tutorial explainshow to download entire libraries of data from the VIROME web application. Wommack, K. E., J. Bhavsar, S. W. Polson, J. Chen, M. Dumas, S. Srinivasiah, M. Furman, S. Jamindar, and D. J. Nasko. 2012. VIROME: a standard operating procedure for analysis of viral metagenome sequences.
Jaysheel Bhavsar +2 more
openaire +2 more sources