Results 91 to 100 of about 18,764 (290)

Targeting Gene-Virotherapy for Cancer [PDF]

Acta Biochimica et Biophysica Sinica, 2005
Gene therapy and viral therapy for cancer have therapeutic effects, but there has been no significant breakthrough in these two forms of therapy. Therefore, a new strategy called "targeting gene-virotherapy", which combines the advantages of gene therapy and viral therapy, has been formulated. This new therapy has stronger antitumor effects than either
Xin-Yuan, Liu, Jing-Fa, Gu, Wen-Fang, Shi   +2 more
openaire   +2 more sources

Principles and Practice Guidelines of Microbiota Medicine: Statements From the CHINAGUT Conference

Microbiota Medicine Research, EarlyView.
The 2025 CHINAGUT Conference convened a panel of 48 clinicians from 39 hospitals in 5 countries to develop 15 key statements, aimed at providing clinicians, educators, and healthcare administrators with a comprehensive framework to advance education, clinical practice, research, and public popularization in microbiota medicine.
Faming Zhang, Zheshun Pi, Sunny Hei Wong, Vineet Ahuja, Serena Porcari, Dai Ishikawa, Hailong Cao, Linlin Chen, Ning Chen, Xiong Chen, Bota Cui, Xiao Ding, Xingxiang He, Jia Hu, Jiang Jin, Ji Li, Weiwei Liao, Jingmei Liu, Ling Liu, Yanyan Liu, Yaping Liu, Yu Liu, Chen Lu, Gaochen Lu, Muhan Lv, Xiangjun Meng, Yongzhan Nie, Qian Ren, Lixuan Sang, Xin Sun, Yang Sun, Hongliang Tian, Baohong Wang, Honggang Wang, Liangjing Wang, Xin Wang, Weihong Wang, Zheyu Wang, Yanling Wei, Quan Wen, Lihao Wu, Xia Wu, Lijing Xiong, Guoliang Ye, Bo Yi, You Yu, Yue Zeng, Huihong Zhai, Ting Zhang, Zulun Zhang, Li Zhou, Li Zhu, Kaichun Wu   +52 more
wiley   +1 more source

An Unconventional Case Study of Neoadjuvant Oncolytic Virotherapy for Recurrent Breast Cancer

Vaccines
Intratumoural oncolytic virotherapy may have promise as a means to debulk and downstage inoperable tumours in preparation for successful surgery. Here, we describe the unique case of a 50-year-old self-experimenting female virologist with locally ...
D. Forčić, Karmen Mršić, M. Perić-Balja, T. Kurtović, S. Ramić, T. Silovski, Ivo Pedišić, Ivan Milas, B. Halassy   +8 more
semanticscholar   +1 more source

Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword

International Journal of Molecular Sciences, 2022
Oncolytic virotherapy is a rapidly progressing field that uses oncolytic viruses (OVs) to selectively infect malignant cells and cause an antitumor response through direct oncolysis and stimulation of the immune system.
Sarah E. Blitz, A. Kappel, F. Gessler, Neil V. Klinger, O. Arnaout, Yi Lu, Pierpaolo Peruzzi, Timothy R. Smith, E. Chiocca, G. Friedman, J. Bernstock   +10 more
semanticscholar   +1 more source

Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley   +1 more source

High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System

Frontiers in Bioengineering and Biotechnology, 2020
Biopharmaceuticals are a large and fast-growing sector of the total pharmaceutical market with antibody-based therapeutics accounting for over 100 billion USD in sales yearly.
Andrew G. Diamos, Andrew G. Diamos, Joseph G. L. Hunter, Joseph G. L. Hunter, Mary D. Pardhe, Mary D. Pardhe, Sun H. Rosenthal, Sun H. Rosenthal, Haiyan Sun, Haiyan Sun, Bonnie C. Foster, Michelle P. DiPalma, Michelle P. DiPalma, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +16 more
doaj   +1 more source

Oncolytic virotherapy and the current approaches in veterinary medicine

German Journal of Veterinary Research, 2022
Cancer has an increasing incidence worldwide in humans and animals. In addition to traditional treatments such as surgery, radiotherapy, and chemotherapy, there is a search for new treatment strategies for cancer treatment.
Bengu Bilgic, Banu Dokuzeylul, Mehmet Or
doaj   +1 more source

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis [PDF]

, 2013
Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of ...
Fujiwara, Toshiyoshi, Kagawa, Shunsuke, Tazawa, Hiroshi   +2 more
core   +1 more source

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Nature Communications
The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatment failures ...
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, A. H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, D. van der Horst, Christoph F Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna S. Twayana, Rasmus N Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E Kiib, Florian E H Kromm, Hauke J. Weiss, Daniele Di Carlo, M. Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, T. Tong, A. Ozsvar, W. Hou, Vivien R. Schack, C. K. Holm, Yunan Zheng, Melanie Ruzek, Joanna M Kalucka, L. de la Vega, W. Elgaher, A. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, L. O'Neill, D. Roy, Markus M. Rinschen, Nadine van Montfoort, J. Diallo, H. Farin, Tommy Alain, D. Olagnier   +49 more
semanticscholar   +1 more source

Oncolytic Virotherapy for Cancer: Clinical Experience

Biomedicines, 2021
Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
S. Chaurasiya, Y. Fong, S. Warner
semanticscholar   +1 more source