Results 91 to 100 of about 17,431 (301)

A Novel Molecular Therapy Using Bioengineered Adenovirus for Human Gastrointestinal Cancer [PDF]

, 2011
Replication-selective tumor-specific viruses constitute a novel approach for treatment of neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Human telomerase is
Fujiwara, Toshiyoshi
core   +1 more source

Impact of SPP1 and HMOX1 Genes in Glioma: Correlations With Oncolytic Virus Infection, Adverse Prognosis and Increased Cell Proliferation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT A high death rate among glioma patients is primarily due to poor prognostic outcomes and tumour metastasis. Oncolytic viruses have gained attention as a potential therapeutic strategy as eliminating tumour cells and modifying tumour microenvironment.
Chunze Cui, Chunyan Wu, Shaoqi Zhang, Xiaofeng Yin   +3 more
wiley   +1 more source

Oncolytic Virotherapy in Solid Tumors: The Challenges and Achievements

Cancers, 2021
Simple Summary Oncolytic virotherapy (OVT) is a promising approach in cancer immunotherapy. Oncolytic viruses (OVs) could be applied in cancer immunotherapy without in-depth knowledge of tumor antigens.
Ke-Tao Jin, Wen-Lin Du, Yuyao Liu, H. Lan, Jingxing Si, X. Mou   +5 more
semanticscholar   +1 more source

The Multifaceted Role of Macrophages in Oncolytic Virotherapy

Viruses, 2021
One of the cancer hallmarks is immune evasion mediated by the tumour microenvironment (TME). Oncolytic virotherapy is a form of immunotherapy based on the application of oncolytic viruses (OVs) that selectively replicate in and induce the death of tumour
Laura Hofman, Sean E. Lawler, Martine L. M. Lamfers   +2 more
doaj   +1 more source

The impact of hypoxia on oncolytic virotherapy [PDF]

, 2011
The hypoxic tumor microenvironment plays significant roles in tumor cell metabolism and survival, tumor growth, and progression. Hypoxia modulates target genes in target cells mainly through an oxygen-sensing signaling pathway mediated by hypoxia ...
Sheng Guo, Z
core   +3 more sources

Targeting Triple‐Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cancer, with no sustainable cure available in the current treatment landscape. Its lack of targets makes it highly unresponsive to various treatment modalities, which is why chemotherapy continues to be the primary form of treatment ...
Rachana Raman, Shristi Debata, Thirupugal Govindarajan, Praveen Kumar   +3 more
wiley   +1 more source

Virotherapy – cancer targeted pharmacology

Drug Discovery Today, 2012
Building on their success in vaccination, many groups are now exploring the use of viruses as anticancer agents. In general, viral therapeutics provide the possibility to express anticancer proteins directly at the tumour site, decreasing exposure to normal tissue during delivery and maximising therapeutic index.
Tedcastle, A, Cawood, R, Di, Y, Fisher, K, Seymour, L   +4 more
openaire   +4 more sources

Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy

Journal for ImmunoTherapy of Cancer, 2021
Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated oncolysis and subsequent antitumor immune responses. Clinical trials of currently available virotherapies showed that robust antitumor immunity characterizes the ...
D. Shin, Teresa T. Nguyen, B. Ozpolat, F. Lang, M. Alonso, C. Gomez-Manzano, J. Fueyo   +6 more
semanticscholar   +1 more source

A genetically modified adenoviral vector with a phage display-derived peptide incorporated into fiber fibritin chimera prolongs survival in experimental glioma [PDF]

, 2015
The dismal clinical context of advanced-grade glioma demands the development of novel therapeutic strategies with direct patient impact. Adenovirus-mediated virotherapy represents a potentially effective approach for glioma therapy.
Ahmed, Atique U, Balyasnikova, Irina V, Chang, Alan L, Curiel, David T, Han, Yu, Kane, J. Robert, Kanojia, Deepak, Kim, Julius W, Lesniak, Maciej S, Miska, Jason, Morshed, Ramin A, Young, Jacob S, Zhang, Lingjiao   +12 more
core   +2 more sources

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source