Literature review: Virus and cancer [PDF]
, 2017 Traballo fin de grao (UDC.CIE). Bioloxía. Curso 2016/2017[Abstract] Cancer is one of the main causes of global mortality, and even though it is considered to be a non-communicable disease, several infectious agents have been found to contribute to ...
Carreira Santos, Sofía
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Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies [PDF]
, 2016 Encouraging results from recent clinical trials are revitalizing the field of oncolytic virotherapies. Human adenovirus type 5 (HAdV-C5/Ad5) is a common vector for its ease of manipulation, high production titers and capacity to transduce multiple cell ...
Chester, John +4 more
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Targeting oncogenic fusion-driven NUT carcinoma with CRISPR-Cas9 genome editing
Molecular Therapy: OncologyNUT carcinoma (NC) is a highly aggressive malignancy characterized by an oncogenic fusion gene incorporating the NUTM1 gene. To date, no established treatment options exist.
Maxim F. Carle +7 more
doaj +1 more source
Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy [PDF]
, 2014 Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis.
Alvarez-Breckenridge, Christopher A. +3 more
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The impact of hypoxia on oncolytic virotherapy [PDF]
, 2011 The hypoxic tumor microenvironment plays significant roles in tumor cell metabolism and survival, tumor growth, and progression. Hypoxia modulates target genes in target cells mainly through an oxygen-sensing signaling pathway mediated by hypoxia ...
Sheng Guo, Z
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HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]
, 2014 Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D +4 more
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The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma [PDF]
, 2015 Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed.
Ayyoub +71 more
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Editorial: Oncolytic virotherapy
Frontiers in Molecular Biosciences, 2023 Ahmed Majeed Al-Shammari +2 more
openaire +3 more sources
Oncolytic Viroradiotherapy for Neuroblastoma [PDF]
, 2014 College of Education and Human Ecology Undergraduate Research ScholarshipNeuroblastoma is the most common extra-cranial solid tumor in childhood and the leading cause of childhood cancer mortality.
Kunkler, Anne
core
Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1 [PDF]
, 2014 Human tumors develop multiple strategies to evade recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic strategies have been developed to reactivate and reorganize the human immune system.
Bernd Heinrich +6 more
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