Results 101 to 110 of about 11,979 (257)

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Journal of Hematology & Oncology, 2021
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far ...
Johannes P. W. Heidbuechel, Christine E. Engeland   +1 more
doaj   +1 more source

Generalized Hamiltonian and Lagrangian aspects of a model for virus–tumor interaction in oncolytic virotherapy

Mathematical Methods in the Applied Sciences, Volume 48, Issue 4, Page 4173-4184, 15 March 2025.
We analyze the generalized Hamiltonian structure of a system of first‐order ordinary differential equations for the Jenner et al. system (Letters in Biomathematics 5 (2018), no. S1, S117–S136). The system of equations is used for modeling the interaction of an oncolytic virus with a tumor cell population.
Partha Guha, Anindya Ghose‐Choudhury
wiley   +1 more source

In vitro and in vivo evaluation of the cyclophosphamide effect along with oncolytic Newcastle disease virus (NDV): An animal preclinical research

Malignancy Spectrum, Volume 2, Issue 1, Page 13-25, March 2025.
This article explores combining Newcastle disease virus (NDV) with chemotherapy for treating breast cancer. Results show promising effects, including tumor suppression and improved patient prognosis without harming healthy tissues. The study suggests that NDV combined with chemotherapy could be a valuable treatment option, highlighting its potential ...
Mohammad Reza Foroughi‐Gilvaee, Alireza Jahandideh, Mohammad Faranoush, Reza Nekouian   +3 more
wiley   +1 more source

Gene and virotherapy for hematological malignancies [PDF]

International Journal of Hematology, 2016
Recent years have seen a transformation in the treatment of hematological malignancies. Advances in gene therapy and molecular techniques and significant gains in computational abilities have supported the rapid development of safer and better tolerated therapies for many patients with hematologic cancers.
Masato Yamamoto, Evidio Domingo-Musibay
openaire   +3 more sources

Lung cancer and oncolytic virotherapy——enemy's enemy

Translational Oncology, 2023
Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li, Zhang Feiyue, Li Gaofeng, Liang Haifeng   +3 more
doaj  

Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses

Veterinary and Comparative Oncology, Volume 23, Issue 1, Page 42-51, March 2025.
ABSTRACT Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low‐grade tumours. As a result, new treatment strategies are being sought.
Yeganeh Mehrani, Julia E. Kakish, Christina Napoleoni, Jennifer Jane Thompson, Jason P. Knapp, Jessica A. Minott, Jacob G. E. Yates, Deirdre Stuart, Brenda L. Coomber, Robert A. Foster, Byram W. Bridle, Khalil Karimi   +11 more
wiley   +1 more source

Targeting Gene-Virotherapy for Cancer [PDF]

Acta Biochimica et Biophysica Sinica, 2005
Gene therapy and viral therapy for cancer have therapeutic effects, but there has been no significant breakthrough in these two forms of therapy. Therefore, a new strategy called "targeting gene-virotherapy", which combines the advantages of gene therapy and viral therapy, has been formulated. This new therapy has stronger antitumor effects than either
Jing-Fa Gu, Xinyuan Liu, Wen-Fang Shi
openaire   +3 more sources

Oncolytic Viruses and the Immune System: The Dynamic Duo

Molecular Therapy: Methods & Clinical Development, 2020
Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach toward cancer treatment. This therapy takes advantage of the natural propensity of most tumor cells to be infected by specific OVs.
Ana Lemos de Matos, Lina S. Franco, Grant McFadden   +2 more
doaj  

Cell cycle‐based antibody selection for suppressing cancer cell growth

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Antibody selection for inducing tumor growth inhibition by in the G0/G1 phase. Cell cycle arrest and programmed cell death are crucial in cancer development, making the regulation of cell fate decisions essential for inducing these processes. We present a novel method using fluorescence‐activated cell sorting (FACS) to select antibodies from a library ...
Chi Hun Song, Chih‐Wei Lin, Kyung Ho Han   +2 more
wiley   +1 more source

Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells

International Journal of Cancer, Volume 156, Issue 3, Page 638-651, 1 February 2025.
What's New? Pancreatic adenocarcinoma is characterized by a high stroma content and an immunosuppressive tissue environment. Here, the authors investigated the capacity of vaccinia viruses to stimulate the human innate immune system upon exposure to pancreatic carcinoma cells.
Ruonan Wang, Mengwen Hu, Isis Lozzi, Cao Zhong Jing Jin, Dou Ma, Katrin Splith, Jörg Mengwasser, Vincent Wolf, Linda Feldbrügge, Peter Tang, Lea Timmermann, Karl Herbert Hillebrandt, Marieluise Kirchner, Philipp Mertins, Georg Hilfenhaus, Christopher Claudius Maximilian Neumann, Thomas Kammertoens, Johann Pratschke, Thomas Malinka, Igor Maximillian Sauer, Elfriede Noessner, Zong Sheng Guo, Matthäus Felsenstein   +22 more
wiley   +1 more source