Results 101 to 110 of about 17,431 (301)

Oncolytic polio virotherapy of cancer [PDF]

Cancer, 2014
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
John H. Sampson, Sarah Gemberling, Henry S. Friedman, Ross W. Walton, Allan H. Friedman, Michael C. Brown, Mikhail I. Dobrikov, Annick Desjardins, Matthias Gromeier, Smita K. Nair, Elena Y. Dobrikova, Douglas S. Tyler, Darell D. Bigner   +12 more
openaire   +3 more sources

Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?

Cancer Cell International, 2022
Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity.
Sara Shayan, Arash Arashkia, Kayhan Azadmanesh   +2 more
doaj   +1 more source

Analysis and analytical simulation for a biophysical fractional diffusive cancer model with virotherapy using the Caputo operator

AIMS Biophysics, 2023
In this paper, a biophysical fractional diffusive cancer model with virotherapy is thoroughly analyzed and analytically simulated. The goal of this biophysical model is to represent both the dynamics of cancer development and the results of virotherapy ...
Mohammed Alabedalhadi , Mohammed Shqair, Ibrahim Saleh   +2 more
doaj   +1 more source

The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient

Cancer Gene Therapy
Colorectal cancer (CRC) is known to be resistant to immunotherapy. In our phase-I clinical trial, one patient achieved a 313-day prolonged response during the combined treatment of oncolytic virotherapy and immunotherapy.
Hangyu Zhang, Yiqing Ren, Feiyu Wang, Xiaoxuan Tu, Z. Tong, Lulu Liu, Yi Zheng, Peng Zhao, Jinlin Cheng, Jianwen Li, Weijia Fang, Xia Liu   +11 more
semanticscholar   +1 more source

Oncolytic Virotherapy: From Bench to Bedside

Frontiers in Cell and Developmental Biology, 2021
Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years.
Ludi Yang, X. Gu, Jie Yu, S. Ge, Xianqun Fan   +4 more
semanticscholar   +1 more source

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms

Frontiers in Cardiovascular Medicine, 2021
The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine protease cascades are critical determinants of morbidity and mortality during infection and with vascular or tissue injury. Both the clot forming (thrombotic) and the
Jordan R. Yaron, Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Shelley E. Haydel, Shelley E. Haydel, Alexandra R. Lucas   +6 more
doaj   +1 more source

The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma [PDF]

, 2015
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed.
Ayyoub, Baeuerle, Bell, Bell, Bell, Benveniste, Bonecchi, Burgert, Chariot, Chieffi, Cobb, Coussens, Curti, Di Cristofano, Dupuy, Fagin, Fernando, Feuerer, Fidler, Fong, Fueyo, Ghosh, Giordano, Guo, Hallden, Hallden, Hanahan, Haugen, Haugen, Hickman, Horwitz, Horwitz, Iwasaki, Kairemo, Karin, Kirn, Kirn, Kracht, Leonardi, Maeda, Mameli, Mantovani, Mantovani, Mantovani, Matsuno, McCart, McKiernan, Melcher, Melillo, Nemunaitis, Okubo, Pinchera, Pollard, Portella, Portella, Portella, Portella, Portella, Portella, Portella, Rabkin, Remick, Ribatti, Rice, Schmittgen, Sheridan, Syed, Tanaka, Udelsman, Vilcek, Weinberg, Wilson   +71 more
core   +2 more sources

Generalized Hamiltonian and Lagrangian aspects of a model for virus–tumor interaction in oncolytic virotherapy

Mathematical Methods in the Applied Sciences, Volume 48, Issue 4, Page 4173-4184, 15 March 2025.
We analyze the generalized Hamiltonian structure of a system of first‐order ordinary differential equations for the Jenner et al. system (Letters in Biomathematics 5 (2018), no. S1, S117–S136). The system of equations is used for modeling the interaction of an oncolytic virus with a tumor cell population.
Partha Guha, Anindya Ghose‐Choudhury
wiley   +1 more source

Immunostimulatory bacterial antigen-armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy.

Journal of Clinical Investigation, 2021
Clinical immunotherapy approaches are lacking efficacy in the treatment of glioblastoma (GBM). In this study, we sought to reverse local and systemic GBM-induced immunosuppression using the Helicobacter pylori neutrophil-activating protein (NAP), a ...
E. Panagioti, C. Kurokawa, K. Viker, Arun Ammayappan, S. K. Anderson, S. Sotiriou, Kyriakos Chatzopoulos, K. Ayasoufi, Aaron J. Johnson, I. Iankov, E. Galanis   +10 more
semanticscholar   +1 more source

Analisa Kestabilan Model Matematika Untuk Penyembuhan Kanker Menggunakan Oncolytic Virotherapy [PDF]

, 2016
Oncolytic virotherapy is one type of cancer treatment using oncolytic virus. In this paper, we will present a mathematical model for treatment of cancer using oncolytic virotherapy with the burst size of a virus (the number of new viruses released from ...
Novellina, V. (Via), Utomo, R. H. (Robertus), Widowati, W. (Widowati)   +2 more
core   +2 more sources