Results 111 to 120 of about 17,431 (301)

In vitro and in vivo evaluation of the cyclophosphamide effect along with oncolytic Newcastle disease virus (NDV): An animal preclinical research

Malignancy Spectrum, Volume 2, Issue 1, Page 13-25, March 2025.
This article explores combining Newcastle disease virus (NDV) with chemotherapy for treating breast cancer. Results show promising effects, including tumor suppression and improved patient prognosis without harming healthy tissues. The study suggests that NDV combined with chemotherapy could be a valuable treatment option, highlighting its potential ...
Mohammad Reza Foroughi‐Gilvaee, Alireza Jahandideh, Mohammad Faranoush, Reza Nekouian   +3 more
wiley   +1 more source

Oncolytic virotherapy reverses the immunosuppressive tumor microenvironment and its potential in combination with immunotherapy

Cancer Cell International, 2021
It has been intensively reported that the immunosuppressive tumor microenvironment (TME) results in tumor resistance to immunotherapy, especially immune checkpoint blockade and chimeric T cell antigen therapy.
Yalei Zhang, Ye Li, Kun Chen, L. Qian, Peng Wang   +4 more
semanticscholar   +1 more source

Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells [PDF]

, 2014
Experimental evolution has been used for various biotechnological applications including protein and microbial cell engineering, but less commonly in the field of oncolytic virotherapy.
A Buckling, A Takaoka, AT Da Poian, BD Lichty, BK Jha, BW Grinnell, C Muñoz-Fontela, Carmen Rivas, DF Stojdl, E Hastie, EJ Faul, F Le Boeuf, G Wollmann, G Wollmann, GJ Letchworth, I Kuhn, I Pagán, I Palmero, IP Greene, IS Novella, J Martínez-Picado, JD Walker, Jean-Simon Diallo, JF Heiber, JJ Bull, JM Cuevas, JM Cuevas, JS Diallo, K Rainwater-Lovett, L Marcos-Villar, L Wu, M Dragosits, Marta M. Alonso, MG Kurilla, O Ebert, P Agudelo-Romero, Pablo Hernández-Alonso, PE Turner, R Alemany, R Belshaw, R Miralles, R Sanjuán, R Sanjuán, RA Burrell, Rafael Sanjuán, Raquel Garijo, RD Socha, S Elena, S Roche, SF Elena, SJ Russell, SK Remold, SP Whelan, TG Uil, TS Miest, V Furió, V Janelle, W Yan, Y Gao, Z Zhang   +59 more
core   +6 more sources

Sorting Out Pandora’s Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma [PDF]

, 2014
Oncolytic viral therapies have recently found their way into clinical application for hepatocellular carcinoma (HCC), a disease with limited treatment options and poor prognosis. Adding to the many intrinsic challenges of in vivo oncolytic viral therapy,
Jennifer Altomonte, Oliver Ebert
core   +3 more sources

Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses

Veterinary and Comparative Oncology, Volume 23, Issue 1, Page 42-51, March 2025.
ABSTRACT Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low‐grade tumours. As a result, new treatment strategies are being sought.
Yeganeh Mehrani, Julia E. Kakish, Christina Napoleoni, Jennifer Jane Thompson, Jason P. Knapp, Jessica A. Minott, Jacob G. E. Yates, Deirdre Stuart, Brenda L. Coomber, Robert A. Foster, Byram W. Bridle, Khalil Karimi   +11 more
wiley   +1 more source

Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination

Nature Communications, 2021
By conferring systemic protection and durable benefits, cancer immunotherapies are emerging as long-term solutions for cancer treatment. One such approach that is currently undergoing clinical testing is a therapeutic anti-cancer vaccine that uses two ...
D. Roy, K. Geoffroy, M. Marguerie, S. T. Khan, N. Martin, J. Kmiecik, D. Bobbala, A. Aitken, C. T. de Souza, K. Stephenson, B. Lichty, R. Auer, D. Stojdl, J. Bell, M. Bourgeois-Daigneault   +14 more
semanticscholar   +1 more source

High Level Production of Monoclonal Antibodies Using an Optimized Plant Expression System

Frontiers in Bioengineering and Biotechnology, 2020
Biopharmaceuticals are a large and fast-growing sector of the total pharmaceutical market with antibody-based therapeutics accounting for over 100 billion USD in sales yearly.
Andrew G. Diamos, Andrew G. Diamos, Joseph G. L. Hunter, Joseph G. L. Hunter, Mary D. Pardhe, Mary D. Pardhe, Sun H. Rosenthal, Sun H. Rosenthal, Haiyan Sun, Haiyan Sun, Bonnie C. Foster, Michelle P. DiPalma, Michelle P. DiPalma, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +16 more
doaj   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

Cell cycle‐based antibody selection for suppressing cancer cell growth

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Antibody selection for inducing tumor growth inhibition by in the G0/G1 phase. Cell cycle arrest and programmed cell death are crucial in cancer development, making the regulation of cell fate decisions essential for inducing these processes. We present a novel method using fluorescence‐activated cell sorting (FACS) to select antibodies from a library ...
Chi Hun Song, Chih‐Wei Lin, Kyung Ho Han   +2 more
wiley   +1 more source

The impact of microbiome dysbiosis on T cell function within the tumor microenvironment (TME)

Frontiers in Cell and Developmental Biology, 2023
Insights into the effect of the microbiome’s composition on immune cell function have recently been discerned and further characterized. Microbiome dysbiosis can result in functional alterations across immune cells, including those required for innate ...
Michelle P. DiPalma, Michelle P. DiPalma, Joseph N. Blattman, Joseph N. Blattman   +3 more
doaj   +1 more source