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Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression. [PDF]
iScienceHorvathova L +7 more
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Oncolytic viruses in head and neck cancers: clinical applications and therapeutic potential. [PDF]
Front MicrobiolGupta A +3 more
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Bibliometric evaluation of research trends and hotspots concerning the interaction between immune checkpoint inhibitors and glioma. [PDF]
Discov OncolXu D, He L, Zhao X, Yang Z.
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2023
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima +2 more
openaire +3 more sources
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima +2 more
openaire +3 more sources
Poxvirus oncolytic virotherapy
Expert Opinion on Biological Therapy, 2019Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Diana Thomas
exaly +3 more sources
Oncolytic virotherapy as immunotherapy
Science, 2021Recognizing immune responses to oncolytic virotherapy opens the way for new ...
Alan, Melcher +2 more
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Personalizing Oncolytic Virotherapy
Human Gene Therapy, 2023The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells. This platform offers a highly specific tumor killing with exceptional safety profiles.
Firas Hamdan +2 more
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Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze +2 more
openaire +2 more sources
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze +2 more
openaire +2 more sources
Optimization of Virotherapy for Cancer
Bulletin of Mathematical Biology, 2009Several viruses preferentially infect and replicate in cancer cells by usurping pathways that are defective in the tumor cell population. Such viruses have a potential as oncolytic agents. The aim of tumor virotherapy is that after injection of the replicating virus, it propagates in the tumor cell population with amplification.
Biesecker, Matt +4 more
openaire +2 more sources