Results 121 to 130 of about 17,431 (301)

An evaluation of the efficacy of adenovirus-mediated gene therapy with p53 for the treatment of cancer [PDF]

, 2015
Cancer is the second leading cause of mortality in the United States today, and equally prevalent throughout the world. Traditional treatments such as chemotherapy and radiotherapy have thus far proven unable to treat the disease with high efficacy, with
Liepart IV, George Hampson
core   +1 more source

Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma [PDF]

, 2010
A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation of proinflammatory, antiviral cytokine ...
Barber, G, Diaz, RM, Galivo, F, Kottke, T, Melcher, A, Thompson, J, Vile, R, Wongthida, P   +7 more
core   +1 more source

Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells

International Journal of Cancer, Volume 156, Issue 3, Page 638-651, 1 February 2025.
What's New? Pancreatic adenocarcinoma is characterized by a high stroma content and an immunosuppressive tissue environment. Here, the authors investigated the capacity of vaccinia viruses to stimulate the human innate immune system upon exposure to pancreatic carcinoma cells.
Ruonan Wang, Mengwen Hu, Isis Lozzi, Cao Zhong Jing Jin, Dou Ma, Katrin Splith, Jörg Mengwasser, Vincent Wolf, Linda Feldbrügge, Peter Tang, Lea Timmermann, Karl Herbert Hillebrandt, Marieluise Kirchner, Philipp Mertins, Georg Hilfenhaus, Christopher Claudius Maximilian Neumann, Thomas Kammertoens, Johann Pratschke, Thomas Malinka, Igor Maximillian Sauer, Elfriede Noessner, Zong Sheng Guo, Matthäus Felsenstein   +22 more
wiley   +1 more source

Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response

Cancers, 2021
Simple Summary Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor. Despite multimodal treatment, the prognosis of GBM patients remains very poor.
E. Stavrakaki, C. Dirven, M. Lamfers
semanticscholar   +1 more source

Current strategies in engaging oncolytic viruses with antitumor immunity

Molecular Therapy: Oncolytics, 2021
Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni, Divya Ravirala, Shaun Xiaoliu Zhang   +2 more
doaj  

Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1 [PDF]

, 2014
Human tumors develop multiple strategies to evade recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic strategies have been developed to reactivate and reorganize the human immune system.
Bernd Heinrich, Caroline J. Breitbach, Jean Rommelaere, Katrin Goepfert, Maike Delic, Markus Moehler, Peter Robert Galle   +6 more
core   +2 more sources

The Use of Gut Organoids: To Study the Physiology and Disease of the Gut Microbiota

Journal of Cellular and Molecular Medicine, Volume 29, Issue 4, February 2025.
ABSTRACT The intestinal flora has attracted much attention in recent years. An imbalance in the intestinal flora can cause not only intestinal diseases but also cause a variety of parenteral diseases, such as endocrine diseases, nervous system diseases and cardiovascular diseases.
Ya Deng, Xiaolu Yuan, XianMin Lu, Jiangbo Wu, Chen Luo, Ting Zhang, Qi Liu, Siqi Tang, Zhuo Li, Xingyi Mu, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie   +13 more
wiley   +1 more source

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Journal of Hematology & Oncology, 2021
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far ...
Johannes P. W. Heidbuechel, Christine E. Engeland   +1 more
doaj   +1 more source

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis [PDF]

, 2013
Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of ...
Fujiwara, Toshiyoshi, Kagawa, Shunsuke, Tazawa, Hiroshi   +2 more
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Decorin Expressed From Herpes Simplex Virus Vector Improves Oncolytic Efficacy in Lung Adenocarcinoma Cells

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT Decorin (DCN) is a small extracellular proteoglycan with significant oncosuppressive activity. Lung adenocarcinoma is commonly devoid of DCN expression and is a leading cause of cancer mortality globally. As a proof‐of‐concept study for evaluating the oncosuppressive potential of DCN expression in lung adenocarcinoma cells, we constructed an ...
Fanny Frejborg, Jussi Palomäki, Kiira Kalke, Julius Orpana, Oliver Koivisto, Henrik Paavilainen, Jessica M. Rosenholm, Hongbo Zhang, Veijo Hukkanen, Hannu Järveläinen   +9 more
wiley   +1 more source