Results 121 to 130 of about 18,764 (290)
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
Journal of Hematology & Oncology, 2021 Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far ...
Johannes P. W. Heidbuechel +1 more
doaj +1 more source
Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies [PDF]
, 2016 Encouraging results from recent clinical trials are revitalizing the field of oncolytic virotherapies. Human adenovirus type 5 (HAdV-C5/Ad5) is a common vector for its ease of manipulation, high production titers and capacity to transduce multiple cell ...
Chester, John +4 more
core +1 more source
Oncolytic polio virotherapy of cancer [PDF]
Cancer, 2014 Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
Michael C, Brown +12 more
openaire +2 more sources
Plant Biotechnology Journal, Volume 23, Issue 11, Page 5013-5031, November 2025.ABSTRACT The plant virus cowpea mosaic virus (CPMV) is being developed as a drug candidate for intratumoral immunotherapy for solid tumours. Data from preclinical studies in mice and rats as well as clinical studies in canine cancer patients demonstrate potent efficacy and an excellent safety profile.
Patrick Opdensteinen +3 more
wiley +1 more source
American Journal of Ophthalmology Case Reports, 2020 Purpose: To describe a case of choroidal melanoma treated with Rigvir® virotherapy in an adjuvant setting. Observations: A female patient born in 1956 presented with a small choroidal melanoma in October 2007. 34 months after transpupillary thermotherapy
Inta Jaunalksne +4 more
doaj +1 more source
Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms
Frontiers in Cardiovascular Medicine, 2021 The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine protease cascades are critical determinants of morbidity and mortality during infection and with vascular or tissue injury. Both the clot forming (thrombotic) and the
Jordan R. Yaron +6 more
doaj +1 more source
Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer [PDF]
, 2016 BACKGROUND: A major hurdle incurrent to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy agents is their limited therapeutic efficacy.
Ashshi, Ahmad Mohammad +4 more
core +2 more sources
Current Approaches for Glioma Gene Therapy and Virotherapy
Frontiers in Molecular Neuroscience, 2021 Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain barrier (BBB), an immunosuppressive tumor microenvironment (TME) and ...
K. Banerjee +13 more
semanticscholar +1 more source
Supplementary Figure 2 from Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer [PDF]
, 2023 Ryo Sakai +9 more
openalex +1 more source
Cancer Cell International, 2022 Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity.
Sara Shayan +2 more
doaj +1 more source