Results 171 to 180 of about 11,703 (213)

Personalizing Oncolytic Virotherapy

Human Gene Therapy, 2023
The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells.
Firas Hamdan, M. Fusciello, V. Cerullo
semanticscholar   +3 more sources

Oncolytic virotherapy: Challenges and solutions.

Current Problems in Cancer, 2020
Viruses as cancer therapies have attracted attention since the 19th century. Scientists observation that viruses can preferentially lyse cancer cells rather than healthy cells, created the field of oncolytic virology.
N. H. Goradel, A. Baker, A. Arashkia, Nasim Ebrahimi, Sajjad Ghorghanlu, B. Negahdari   +5 more
semanticscholar   +3 more sources

Oncolytic Virotherapy

2023
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima, Deeba, Amraiz, Muhammad Tariq, Navid   +2 more
openaire   +3 more sources

Poxvirus oncolytic virotherapy

Expert Opinion on Biological Therapy, 2019
Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Grant Mcfadden
exaly   +3 more sources

Optimization of Virotherapy for Cancer

Bulletin of Mathematical Biology, 2009
Several viruses preferentially infect and replicate in cancer cells by usurping pathways that are defective in the tumor cell population. Such viruses have a potential as oncolytic agents. The aim of tumor virotherapy is that after injection of the replicating virus, it propagates in the tumor cell population with amplification.
Jung-Han Kimn, David Dingli, Zeljko Bajzer   +2 more
exaly   +3 more sources

Oncolytic Virotherapy

Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze, Tony R, Reid, Steven C, Rose   +2 more
openaire   +2 more sources

Potential targeting of the tumor microenvironment to improve cancer virotherapy.

Pharmacology and Therapeutics, 2023
In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant adeno-associated virus (AAV) delivery was also approved. However, systemic administration remains challenging due to the limited number of viruses that successfully ...
Z. Liao, S. Hsu, S. Tang, I. Kempson, Pan-Chyr Yang, S. Tseng   +5 more
semanticscholar   +1 more source

Pevonedistat, a First in-class NEDD8-activating Enzyme Inhibitor, sensitizes cancer cells to VSVΔ51 Oncolytic Virotherapy.

Molecular Therapy, 2023
The clinical efficacy of VSVΔ51 oncolytic virotherapy has been limited by tumor resistance to viral infection, thus strategies to transiently repress antiviral defenses are warranted.
Boaz Wong, A. Bergeron, Glib Maznyi, Kristy Ng, A. Jirovec, H. Birdi, D. Serrano, Marcus M. Spinelli, Max Thomson, Zaid Taha, Akram Alwithenani, Andrew Chen, Ian Lorimer, B. Vanderhyden, R. Arulanandam, J. Diallo   +15 more
semanticscholar   +1 more source

Syncytia Formation in Oncolytic Virotherapy [PDF]

Molecular Therapy - Oncolytics, 2019
Oncolytic virotherapy uses replication-competent virus as a means of treating cancer. Whereas this field has shown great promise as a viable treatment method, the limited spread of these viruses throughout the tumor microenvironment remains a major challenge. To overcome this issue, researchers have begun looking at syncytia formation as a novel method
Eric Bartee
exaly   +4 more sources