Results 51 to 60 of about 8,549 (213)

The Multifaceted Role of Macrophages in Oncolytic Virotherapy

Viruses, 2021
One of the cancer hallmarks is immune evasion mediated by the tumour microenvironment (TME). Oncolytic virotherapy is a form of immunotherapy based on the application of oncolytic viruses (OVs) that selectively replicate in and induce the death of tumour
Laura Hofman, Sean E. Lawler, Martine L. M. Lamfers   +2 more
doaj   +1 more source

Virotherapy – cancer targeted pharmacology

Drug Discovery Today, 2012
Building on their success in vaccination, many groups are now exploring the use of viruses as anticancer agents. In general, viral therapeutics provide the possibility to express anticancer proteins directly at the tumour site, decreasing exposure to normal tissue during delivery and maximising therapeutic index.
Tedcastle, A, Cawood, R, Di, Y, Fisher, K, Seymour, L   +4 more
openaire   +4 more sources

Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?

Cancer Cell International, 2022
Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity.
Sara Shayan, Arash Arashkia, Kayhan Azadmanesh   +2 more
doaj   +1 more source

Analysis and analytical simulation for a biophysical fractional diffusive cancer model with virotherapy using the Caputo operator

AIMS Biophysics, 2023
In this paper, a biophysical fractional diffusive cancer model with virotherapy is thoroughly analyzed and analytically simulated. The goal of this biophysical model is to represent both the dynamics of cancer development and the results of virotherapy ...
Mohammed Alabedalhadi , Mohammed Shqair, Ibrahim Saleh   +2 more
doaj   +1 more source

Impact of SPP1 and HMOX1 Genes in Glioma: Correlations With Oncolytic Virus Infection, Adverse Prognosis and Increased Cell Proliferation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT A high death rate among glioma patients is primarily due to poor prognostic outcomes and tumour metastasis. Oncolytic viruses have gained attention as a potential therapeutic strategy as eliminating tumour cells and modifying tumour microenvironment.
Chunze Cui, Chunyan Wu, Shaoqi Zhang, Xiaofeng Yin   +3 more
wiley   +1 more source

Targeting Triple‐Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cancer, with no sustainable cure available in the current treatment landscape. Its lack of targets makes it highly unresponsive to various treatment modalities, which is why chemotherapy continues to be the primary form of treatment ...
Rachana Raman, Shristi Debata, Thirupugal Govindarajan, Praveen Kumar   +3 more
wiley   +1 more source

Oncolytic polio virotherapy of cancer [PDF]

Cancer, 2014
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
John H. Sampson, Sarah Gemberling, Henry S. Friedman, Ross W. Walton, Allan H. Friedman, Michael C. Brown, Mikhail I. Dobrikov, Annick Desjardins, Matthias Gromeier, Smita K. Nair, Elena Y. Dobrikova, Douglas S. Tyler, Darell D. Bigner   +12 more
openaire   +3 more sources

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms

Frontiers in Cardiovascular Medicine, 2021
The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine protease cascades are critical determinants of morbidity and mortality during infection and with vascular or tissue injury. Both the clot forming (thrombotic) and the
Jordan R. Yaron, Jordan R. Yaron, Liqiang Zhang, Qiuyun Guo, Shelley E. Haydel, Shelley E. Haydel, Alexandra R. Lucas   +6 more
doaj   +1 more source

Generalized Hamiltonian and Lagrangian aspects of a model for virus–tumor interaction in oncolytic virotherapy

Mathematical Methods in the Applied Sciences, Volume 48, Issue 4, Page 4173-4184, 15 March 2025.
We analyze the generalized Hamiltonian structure of a system of first‐order ordinary differential equations for the Jenner et al. system (Letters in Biomathematics 5 (2018), no. S1, S117–S136). The system of equations is used for modeling the interaction of an oncolytic virus with a tumor cell population.
Partha Guha, Anindya Ghose‐Choudhury
wiley   +1 more source