Results 81 to 90 of about 18,764 (290)

Oncolytic Virotherapy with Myxoma Virus [PDF]

Journal of Clinical Medicine, 2020
Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers. They selectively infect and kill cancer cells while sparing the normal counterparts, expose cancer- specific antigens and activate the host immune system against both viral and tumor determinants.
Masmudur M. Rahman, Grant McFadden
openaire   +2 more sources

Retargeted adenoviruses for radiation-guided gene delivery [PDF]

, 2016
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz, AP Patel, BL Davidson, C Roller, Cancer Genome Atlas Research Network, D E Hallahan, DA Boothman, DA Reardon, DA Spencer, DE Hallahan, DY Dadey, F Tameire, G Bajocchi, H Hsu, H Li, H Yan, HO McCarthy, JJ Mezhir, K Daino, L N Kaliberova, LM Hendershot, M Gonzalez-Gronow, M Hamdi, M Martin, M Westphal, MA Arap, MJ Gray, N Belousova, N Mittereder, R Datta, R Stupp, R Stupp, RJ Passarella, RR Weichselbaum, S A Kaliberov, S Akli, S Mittal, S Parisi, S Takahashi, SA Kaliberov, SC Noureddini, SL Eck, SS Talibi, T Ichikawa, TA Ajith, TC He, Ulasov IV, V Kapoor, VN Krasnykh, WL Blalock, WW Zhang, X Xing, Y Touchefeu, Y Zhang, YL Tsai   +54 more
core   +2 more sources

The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics

Pathogens
Cutaneous T-cell lymphoma (CTCL) is a devastating, potentially fatal T-lymphocyte malignancy affecting the skin. Despite all efforts, the etiology of this disease remains unknown.
Assia Angelova, Jean Rommelaere, Guy Ungerechts   +2 more
doaj   +1 more source

Myxoma Virus dsRNA Binding Protein M029  Inhibits the Type I IFN‐Induced Antiviral State in a  Highly Species‐Specific Fashion

Viruses, 2017
Myxoma virus (MYXV) is Leporipoxvirus that possesses a specific rabbit‐restricted host tropism but exhibits a much broader  cellular host range in cultured cells.
Masmudur M. Rahman, Grant McFadden
doaj   +1 more source

Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis

, 2018
Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects.
Eladdadi, Amina, Malinzi, Joseph, Ouifki, Rachid, Torres, Delfim F. M., White, K. A. Jane   +4 more
core   +1 more source

A genetically modified adenoviral vector with a phage display-derived peptide incorporated into fiber fibritin chimera prolongs survival in experimental glioma [PDF]

, 2015
The dismal clinical context of advanced-grade glioma demands the development of novel therapeutic strategies with direct patient impact. Adenovirus-mediated virotherapy represents a potentially effective approach for glioma therapy.
Ahmed, Atique U, Balyasnikova, Irina V, Chang, Alan L, Curiel, David T, Han, Yu, Kane, J. Robert, Kanojia, Deepak, Kim, Julius W, Lesniak, Maciej S, Miska, Jason, Morshed, Ramin A, Young, Jacob S, Zhang, Lingjiao   +12 more
core   +2 more sources

Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

Nature Communications, 2022
Immunotherapies directly enhancing anti-tumor CD8^+ T cell responses have yielded measurable but limited success, highlighting the need for alternatives.
J. Svensson-Arvelund, Sara Cuadrado-Castano, Gvantsa Pantsulaia, Kristy Kim, Mark Aleynick, L. Hammerich, R. Upadhyay, M. Yellin, H. Marsh, Daniel Oreper, S. Jhunjhunwala, C. Moussion, M. Merad, Brian D. Brown, A. García-Sastre, J. Brody   +15 more
semanticscholar   +1 more source

The role of viruses in cancer development versus cancer therapy: An oncological perspective

Cancer Medicine, 2023
Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents.
Hossein Javid, Alireza Sharbaf Mashhad, Shaghayegh Yazdani, Mahsa Akbari Oryani, Sanaz Akbari, Nastaran Rezagholinejad, Mahboubeh Tajaldini, Mehdi Karimi‐Shahri   +7 more
doaj   +1 more source

Combination therapy with reovirus and anti-PD-1 blockade controls tumor growth through innate and adaptive immune responses. [PDF]

, 2016
Oncolytic reovirus can be delivered both systemically and intratumorally, in both pre-clinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and anti-tumor activity is directly ...
Coffey, M, Diaz, RM, Harrington, K, Ilett, E, Kottke, T, Melcher, A, Pandha, H, Parrish, C, Rajani, K, Shim, KG, Thompson, J, Vile, R, Zaidi, S   +12 more
core   +1 more source

Combination of Oncolytic Virotherapy with Different Antitumor Approaches against Glioblastoma

International Journal of Molecular Sciences
Glioblastoma is one of the most malignant and aggressive tumors of the central nervous system. Despite the standard therapy consisting of maximal surgical resection and chemo- and radiotherapy, the median survival of patients with this diagnosis is about
A. Ageenko, N. Vasileva, Vladimir Richter, E. Kuligina   +3 more
semanticscholar   +1 more source