Results 81 to 90 of about 17,431 (301)

Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy [PDF]

, 2016
Ovarian cancer accounts for >140 000 deaths globally each year. Typically, disease is asymptomatic until an advanced, incurable stage. Although response to cytotoxic chemotherapy is frequently observed, resistance to conventional platinum-based therapies
A Hemminki, A L Parker, AD Gaggar, AL Parker, AL Parker, C Larson, CK Ingemarsdotter, D Jelovac, D Stone, E D'Ambrosio, E Nwanegbo, EV Shashkova, F Sakurai, H Uusi-Kerttula, H Uusi-Kerttula, H Uusi-Kerttula, H Wang, J D Chester, JA Greig, JM Bergelson, JS Kim, K Doronin, KM White, L Coughlan, L Hanna, L Thorsteinsson, M Kim, P Abbink, P Sova, R Alba, R Jones, R Vogels, R Waehler, RJ Stanton, S Corjon, S L Hulin-Curtis, SC Stevenson, SN Waddington, W Saitoh-Inagawa, Z Xu, Z You   +40 more
core   +1 more source

Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

Molecular Therapy: Oncolytics, 2021
Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and surgical resection, but there is no single treatment or combination ...
John D. Christie, Nicole Appel, Hannah Canter, Jazmin Galvan Achi, Natalie M. Elliott, Ana Lemos de Matos, Lina Franco, Jacquelyn Kilbourne, Kenneth Lowe, Masmudur M. Rahman, Nancy Y. Villa, Joshua Carmen, Evelyn Luna, Joseph Blattman, Grant McFadden   +14 more
doaj  

The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy

Frontiers in Immunology
Despite significant advances in our knowledge regarding the genetics and molecular biology of gliomas over the past two decades and hundreds of clinical trials, no effective therapeutic approach has been identified for adult patients with newly diagnosed
A. A. Stepanenko, A. Sosnovtseva, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Victor A. Naumenko, V. Chekhonin   +6 more
semanticscholar   +1 more source

Oncolytic virotherapy and the current approaches in veterinary medicine

German Journal of Veterinary Research, 2022
Cancer has an increasing incidence worldwide in humans and animals. In addition to traditional treatments such as surgery, radiotherapy, and chemotherapy, there is a search for new treatment strategies for cancer treatment.
Bengu Bilgic, Banu Dokuzeylul, Mehmet Or
doaj   +1 more source

How Can We Stop Cancer? [PDF]

, 2020
Cancer is a disease that humans have been struggling to combat for centuries. It originates from the accumulation of several mutations over the life of a cell that causes it to evade cell death and multiply rapidly.
Current, Joseph R
core   +1 more source

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. [PDF]

, 2017
LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM).
Agbandje-McKenna, Mavis, Baker, Timothy S, Chipman, Paul, Cotmore, Susan, D'Abramo, Anthony, Geilen, Lorena, Halder, Sujata, Janssen, Mandy, Kurian, Justin, Mckenna, Robert, Misseldine, Adam, Pittman, Nikéa, Smith, J Kennon, Tattersall, Peter   +13 more
core   +3 more sources

Oncolytic Virotherapy for Hematological Malignancies [PDF]

Advances in Virology, 2012
Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. For high-risk disease, hematopoietic stem cell transplant (HCT) can be used. However, in the setting of autologous HCT, relapse due to contamination of the autograft with cancer ...
Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle   +4 more
openaire   +4 more sources

Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer

Journal of Biomedical Sciences
Background As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results
D. Ou, Z. Liao, I. Kempson, Lin Li, Pan-Chyr Yang, S. Tseng   +5 more
semanticscholar   +1 more source

A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report

SAGE Open Medical Case Reports, 2020
Melanoma is an aggressive skin cancer form with a grave prognosis. Current results suggest that oncolytic virus treatment of melanoma has a high therapeutic potential. ECHO-7 (Rigvir) is the first oncolytic virus registered in Latvia.
Vladimirs Sorokins, Andra Tilgase, Evija Olmane, Sergejs Isajevs, Tatjana Zablocka, Agnija Rasa, Pēteris Alberts   +6 more
doaj   +1 more source

Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model

Frontiers in Immunology, 2023
IntroductionPancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB.
Rūta Veinalde, Gemma Pidelaserra-Martí, Gemma Pidelaserra-Martí, Gemma Pidelaserra-Martí, Coline Moulin, Coline Moulin, Chin Leng Tan, Chin Leng Tan, Theresa E. Schäfer, Na Kang, Claudia R. Ball, Claudia R. Ball, Jonas Leichsenring, Jonas Leichsenring, Albrecht Stenzinger, Lars Kaderali, Dirk Jäger, Dirk Jäger, Guy Ungerechts, Guy Ungerechts, Christine E. Engeland, Christine E. Engeland, Christine E. Engeland   +22 more
doaj   +1 more source