Results 41 to 50 of about 1,942 (154)
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals [PDF]
, 2010 International audienceGeneric PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive modelling of inter-individual variability in the absorption, distribution, metabolism
Bois, Frédéric Y. +2 more
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In silico, experimental, mechanistic model for extended-release felodipine disposition exhibiting complex absorption and a highly variable food interaction [PDF]
, 2014 The objective of this study was to develop and explore new, in silico experimental methods for deciphering complex, highly variable absorption and food interaction pharmacokinetics observed for a modified-release drug product.
Hunt, CA, Jackson, AJ, Kim, SHJ
core +1 more source
Clinical and Translational Science, 2023 In vitro‐in vivo correlation (IVIVC) allows prediction of the in vivo performance of a pharmaceutical product based on its in vitro drug release profiles and can be used to reduce the number of bioequivalence (BE) studies during product development, and ...
Jiaying Wang +7 more
doaj +1 more source
Pharmaceutics, 2023 Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time.
Marcela Staniszewska +8 more
doaj +1 more source
Pricing and Reimbursement in U.S. Pharmaceutical Markets [PDF]
, 2010 In this survey chapter on pricing and reimbursement in U.S. pharmaceutical markets, we first provide background information on important federal legislation, institutional details regarding distribution channel logistics, definitions of alternative price
Berndt, Ernst R., Newhouse, Joseph Paul
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro–in vivo ...
Joyce S. Macwan +4 more
doaj +1 more source
Pharmaceuticals, 2021 Sample sizes for single-period clinical trials, including pharmacokinetic studies, are statistically determined by within-subject variability (WSV).
Won-ho Kang +10 more
doaj +1 more source
Pharmacokinetic studies in children: recommendations for practice and research. [PDF]
, 2018 Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation and paediatric clinical pharmacology, yet there remain ...
Barker, CIS +7 more
core +6 more sources
Selection of medicines in Chilean public hospitals: an exploratory study [PDF]
, 2013 Background There is a growing interest in high income countries to control expenditure on medicines by improving the rationale for their selection. However, in middle income countries with differing priorities and needs, little attention has been paid
Barber, N, Collao, JF, Smith, F
core +2 more sources
Pharmaceutics, 2022 The development of extended-release dosage forms with adequate drug release is a challenge for pharmaceutical companies, mainly when the drug presents high solubility, as in Biopharmaceutics Classification System (BCS) class I.
Michele Georges Issa +4 more
doaj +1 more source