Results 61 to 70 of about 1,942 (154)

Nanoinformatics knowledge infrastructures: bringing efficient information management to nanomedical research [PDF]

, 2013
Nanotechnology represents an area of particular promise and significant opportunity across multiple scientific disciplines. Ongoing nanotechnology research ranges from the characterization of nanoparticles and nanomaterials to the analysis and processing
Baker N A, D de la Iglesia, de la Iglesia D, de Mel A, Freitas R AJr, García-Remesal M, Kumbar S G, Lemley M A, M García-Remesal, Maojo V, Maojo V, McNeil S E ed McNeil S E, Murashov V, Musen M A, National Science, Ostraat M L, Petre C E, R E Cachau, Tanaka M, V Maojo, Weidl T, Yeri A   +21 more
core   +2 more sources

Integration of Biorelevant Pediatric Dissolution Methodology into PBPK Modeling to Predict In Vivo Performance and Bioequivalence of Generic Drugs in Pediatric Populations:a Carbamazepine Case Study [PDF]

, 2023
This study investigated the impact of gastro-intestinal fluid volume and bile salt (BS) concentration on the dissolution of carbamazepine (CBZ) immediate release (IR) 100 mg tablets and to integrate these in vitro biorelevant dissolution profiles into ...
Al Shoyaib, Abdullah, Batchelor, Hannah K., Burckart, Gilbert J., Fang, Lanyan, Feng, Kairui, Jones, Marie-Christine, Mousa, Youssef M., Pawar, Gopal, Wu, Fang, Zhao, Liang   +9 more
core   +2 more sources

Efficacy, Safety and PK of Once‐Daily Oral Semaglutide 25 mg for Obesity With and Without Type 2 Diabetes in Comparison With Subcutaneous Semaglutide 2.4 mg: A Model‐Informed Drug Development Approach

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide has previously been approved for weight management and cardiovascular disease as a subcutaneous formulation, and more recently also as an oral formulation. However, there is limited information across oral dose levels, and there are no studies for the 25 mg dose in people with obesity and type 2 diabetes (T2D).
Rune Viig Overgaard, Oscar Birkhan, Naveen Rathor, Thomas Sparsø, Anders Strathe, Sean Wharton, Domenica Rubino   +6 more
wiley   +1 more source

The Prevalence of Philippine Prescribing, Dispensing, and Use Behavior in Relation to Generic Drugs and their Risk Factors [PDF]

, 2014
This study was designed to address the issue of compliance of physicians and drugstores to the provisions of Generics Act of 1988. Furthermore, it aims to explore the awareness of consumers on generic medicines to explain current trends and practices in ...
Baclay, J. Richelcyn M., Duque, Richelle G., Ronsing, Aisha-Aziza A., Roque, Patricia Margarita S., Serrano, Grace Kathleen T., Tumlos, Jenina Olivia A., Wong, John Q.   +6 more
core  

Biopharmaceutic Prediction of Oral Absorption from Immediate Release Dosage Forms [PDF]

, 2022
Characterization of the efficacy and safety of pharmaceuticals is typically carried out by the pharmaceutical industry through assessment of pharmacokinetics in clinical trials performed in humans. However, outcomes of those studies do not depend only on
García Alcalde, Mauricio Andrés
core   +1 more source

Virtual Bioequivalence Assessment of Tofacitinib Once Daily Modified Release Dosage Form in Pediatric Subjects

The AAPS Journal
Abstract Tofacitinib is a potent, selective inhibitor of the Janus kinase (JAK) family of kinases with a high degree of selectivity within the human genome’s set of protein kinases. Currently approved formulations for tofacitinib citrate are immediate release (IR) tablets, modified release (MR) tablets and IR solution.
Kazuko Sagawa, Vivek Purohit, Vu Le, Hao-Jui Hsu, Martin E. Dowty, Susanna Tse, Cheng Chang   +6 more
openaire   +2 more sources

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Mechanism‐Based Predictions of Local Tissue and Systemic Exposure for Drug Products Delivered Through the Female Reproductive Tract

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Effective drug delivery through the female reproductive tract (FRT) presents unique challenges due to the lack of robust predictive models for drug exposure via this route. Addressing this gap, we developed and evaluated a comprehensive whole‐body physiologically based pharmacokinetic (PBPK) model that incorporates anatomical and physiological
Xinnong Li, Thomas Straubinger, Lisa C. Rohan, Sharon L. Achilles, Beatrice A. Chen, Guru Valicherla, Zhongfang Zhang, Mark Donnelly, Eleftheria Tsakalozou, Liang Zhao, Robert Bies   +10 more
wiley   +1 more source

Computational Study of Hydrogel Ring Device for Ocular Drug Delivery [PDF]

, 2018
Researchers have developed many different kinds of ocular drug delivery devices. However, most address anterior eye disorders—very few are designed specifically for the treatment of posterior eye diseases.
Hanif, Sarah, Lim, Abigail, Sit, Hilarie, Tan, Wan Qing Melissa   +3 more
core  

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Hereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein. Donidalorsen is an antisense oligonucleotide designed to selectively degrade prekallikrein messenger RNA and thereby reduce prekallikrein production.
John K. Diep, Miao Liu, Pratap Singh, Steve Dorow, Danny M. Cohn, Laura Bordone, Kenneth B. Newman, Xiang Gao   +7 more
wiley   +1 more source