Results 81 to 90 of about 4,403,980 (152)

Physiologically based absorption modeling to predict the bioequivalence of two apixaban formulations

Clinical and Translational Science
The equivalence of absorption rates and extents between generic drugs and their reference formulations is crucial for ensuring therapeutic comparability.
Ting Luo, Lu Wang, Zourong Ruan, Honggang Lou, Dandan Yang, Zhiyang Wang, Pengfei Zhao, Bo Jiang   +7 more
doaj   +1 more source

Artificial Intelligence Meets Bioequivalence: Using Generative Adversarial Networks for Smarter, Smaller Trials

Machine Learning and Knowledge Extraction
This study introduces artificial intelligence as a powerful tool to transform bioequivalence (BE) trials. We apply advanced generative models, specifically Wasserstein Generative Adversarial Networks (WGANs), to create virtual subjects and reduce the ...
Anastasios Nikolopoulos, Vangelis D. Karalis   +1 more
doaj   +1 more source

Human factors consideration in the interaction process with virtual environment [PDF]

, 2010
Newrequirements are needed by industry for computer aided design (CAD) data. Some techniques of CAD data management and the computer power unit capabilities enable an extraction of a virtual mock-up for an interactive use.
MERIENNE, Frédéric
core  

Advancements in Virtual Bioequivalence: Computational Methods and Regulatory Perspectives in the Pharmaceutical Industry

Background/Objectives: The rise of virtual bioequivalence studies has transformed the pharmaceutical landscape, enabling more efficient drug development processes. This systematic review aims to explore advancements in Physiologically-Based Pharmacokinetic (PBPK) modeling, its regulatory implications, and its role in achieving virtual bioequivalence ...
Nasser Alotaiq, Doni Dermawan
openaire   +1 more source

Bioequivalence evaluation of epinephrine autoinjectors with attention to rapid delivery

, 2013
David Alexander Sclar Department of Pharmacy Practice, College of Pharmacy, Midwestern University, Glendale, AZ, USA Abstract: Timely and proper injection of epinephrine is critical to prevent serious consequences relating to anaphylaxis.
Sclar DA
core  

Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified‐Release Dosage Form

Clinical Pharmacology & Therapeutics
Tofacitinib is a potent, selective inhibitor of the Janus kinase (JAK) family of kinases with a high degree of selectivity within the human genome's set of protein kinases. Currently approved formulations for tofacitinib citrate are immediate‐release (IR) tablets, modified‐release (MR) tablets, and IR solution.
Vivek Purohit, Kazuko Sagawa, Hao‐Jui Hsu, Joseph Kushner, Martin E. Dowty, Susanna Tse, Jian Lin, Andrew Blanchard, Arnab Mukherjee, Vu Le, Cheng Chang   +10 more
openaire   +2 more sources

Bioequivalence Studies of Highly Variable Drugs: An Old Problem Addressed by Artificial Neural Networks

Applied Sciences
The bioequivalence (BE) of highly variable drugs is a complex issue in the pharmaceutical industry. The impact of this variability can significantly affect the required sample size and statistical power.
Dimitris Papadopoulos, Georgia Karali, Vangelis D. Karalis   +2 more
doaj   +1 more source

Virtual reality learning software for individuals with intellectual disabilities : comparison between touchscreen and mouse interactions [PDF]

, 2012
The aim of this article is to analyze the impact of two user interfaces - a tactile interface and a computer mouse - in a virtual environment allowing self-learning tasks, such as dishwashing, by workers with mental deficiencies.
DAMIANO, Romain, LOUP-ESCANDE, Emilie, HERNOUX, Franck, RICHIR, Simon, CHRISTMANN, Olivier   +4 more
core  

PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox

Разработка и регистрация лекарственных средств
Introduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova, P. A. Losenkova, Yu. V. Medvedev, E. A. Malashenko, I. E. Makarenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Fed and Fasting Bioequivalence Study for Two Formulations of Bosentan 125 Mg Tablets in Healthy Colombian People

, 2015
6 páginasThis is a pharmacokinetic study of two formulations containing Bosentan 125 mg, in order to compare the bioavailability between the Test product (Bosentan produced by Tecnoquímicas S.A.
Bustamante C., Villarraga EA., Vargas M.
core   +1 more source