Results 91 to 100 of about 1,942 (154)

DESIGN AND DEVELOPMENT OF A MICROFLUIDIC DEVICE FOR THE ASSESSMENT OF FIRST-PASS METABOLISM [PDF]

, 2017
The aim of the thesis is to develop a microfluidic platform in order to mimic the first pass metabolism of oral ingested compounds. In the first part of the thesis, there is an introduction about the in vivo mechanism involved in the in process of first ...
Corrado, Brunella
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Approaches to conducting a physiologically relevant test (PRT) in the study of medicines containing substance IIc of the BCS subclass using sorafenib as an example

Разработка и регистрация лекарственных средств
Introduction. Sorafenib is an antineoplastic drug belonging to class IIc according to the biopharmaceutical classification system (BCS) due to the presence of both acidic and basic properties.
A. V. Suvorova, Yu. V. Medvedev, P. A. Losenkova, O. S. Kramarenko, E. A. Malashenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference [PDF]

At the 6th International Conference of the Global Bioequivalence Harmonisation Initiative (GBHI), co-organised by the European Federation of Pharmaceutical Sciences (EUFEPS) and the Product Quality Research Institute (PQRI), critical bioequivalence (BE ...
Beuerle, G., Bilensoy, E., Cook, J., Fernandes, E., Haertter, S., Kuribayashi, R., Mehta, M., Paixao, P., Schug, B., Seidlitz, Anne   +9 more
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Does Pharmaceutical Price Regulation Affect the Adoption of Generic Competition? Evidence from the OECD, 1999-2008 [PDF]

Generic competition in the pharmaceutical market is an effective cost-containment mechanism that improves static efficiency and stimulates pharmaceutical innovation. There is no prior study that has empirically analysed the relative delays in adoption of
Alistair McGuire, Joan Costa-i-Font, Nebibe Varol   +2 more
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Reference Pricing of Pharmaceuticals for Medicare: Evidence from Germany, the Netherlands and New Zealand [PDF]

This paper describes three prototypical systems of therapeutic reference pricing (RP) for pharmaceuticals -- Germany, the Netherlands, and New Zealand -- and examines their effects on the availability of new drugs, reimbursement levels, manufacturer ...
Jonathan D. Ketcham, Patricia M. Danzon
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Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant dissolution testing

Drug Development and Industrial Pharmacy
The aim of the present study was to assess the accuracy of the PBPK model in predicting the pharmacokinetic behavior of weakly acidic BCS class II drugs in humans through a multipronged approach of in vitro dissolution, in vivo studies, and in silico simulations.
Bai, Chenxia, Zhang, Jiaming, Xu, Xiaolan, Li, Xiaoting, Zhang, Tianhong   +4 more
openaire   +1 more source

Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices, Vol. 1 [PDF]

, 2007
Prepared by and for policy-makers, leaders of public sector research establishments, technology transfer professionals, licensing executives, and scientists, this online resource offers up-to-date information and strategies for utilizing the power of ...
Bennett, Alan B., Fernandez, Carlos, Graff, Gregory D., Kowalski, Stanley, Krattiger, Anatole, Mahoney, Richard T., Nelsen, Lita, Satyanarayana, Kanikaram, Thomson, Jennifer A.   +8 more
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Assessing the impact of alternative patent systems on the cost of health care: the TPPA and HIV treatment in Vietnam

, 2014
In the Trans Pacific partnership Agreement (TPPA) negotiations, the United States has proposed expanded patent protections that will likely impact the affordability of medicines in TPPA partners.
Gleeson, Deborah, Lopert, Ruth, Moir, Hazel V J, Tenni, Brigitte   +3 more
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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers [PDF]

[EN] The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies.
Bandín-Vilar, Enrique, García-Arieta, Alfredo, M. Cuquerella-Gilabert, Mangas-Sanjuán, Victor, Merino-Sanjuán, Matilde, Reig-López, Javier   +5 more
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DoR Communicator - May 2014 [PDF]

, 2014
The May 2014 issue of the Division of Research newsletter.https://digitalcommons.fiu.edu/research_newsletter/1012/thumbnail ...
Division of Research, Florida International University
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