Results 91 to 100 of about 4,403,980 (152)

Bioequivalence study models and software tools. [PDF]

, 2011
When introducing new drugs to the market in pharmaceutical industry, researchers have to solve bioequivalence problem using statistical methods. In some occasions different conclusions about bioequivalence are made from the same data, when using several ...
Vileiniškis, Marius,
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Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant dissolution testing

Drug Development and Industrial Pharmacy
The aim of the present study was to assess the accuracy of the PBPK model in predicting the pharmacokinetic behavior of weakly acidic BCS class II drugs in humans through a multipronged approach of in vitro dissolution, in vivo studies, and in silico simulations.
Chenxia, Bai, Jiaming, Zhang, Xiaolan, Xu, Xiaoting, Li, Tianhong, Zhang   +4 more
openaire   +2 more sources

Approaches to conducting a physiologically relevant test (PRT) in the study of medicines containing substance IIc of the BCS subclass using sorafenib as an example

Разработка и регистрация лекарственных средств
Introduction. Sorafenib is an antineoplastic drug belonging to class IIc according to the biopharmaceutical classification system (BCS) due to the presence of both acidic and basic properties.
A. V. Suvorova, Yu. V. Medvedev, P. A. Losenkova, O. S. Kramarenko, E. A. Malashenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions

, 2023
Wanjun Bai,1 Haojing Song,1 Yiting Hu,1 Xueyuan Zhang,2 Xiaoru Wang,3 Caihui Guo,1 Bo Qiu,1 Zhanjun Dong1 1Department of Pharmacy, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Shanghai Innovstone Therapeutics Limited ...
Hu Y, Zhang X, Dong Z, Qiu B, Wang X, Guo C, Song H, Bai W   +7 more
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Demonstration of in vitro-in vivo relationship (IVIVR) and virtual bioequivalence (VBE) between progesterone intravaginal rings using physiologically based pharmacokinetic (PBPK) modelling

Journal of Pharmaceutical Sciences
The vaginal route of administration enables convenient local and systemic drug delivery with the avoidance of hepatic first-pass metabolism. Considering the clinical advantages of vaginal delivery, development of physiologically based pharmacokinetic (PBPK) models of vaginal absorption to inform drug and formulation development is deemed valuable.
Kanika Thakur, Ola Sternebring, Yu-E Zhang, Kevin Wyckoff, Iain Macdonald, Philippe Pinton, Daniel Paterson, Krishna Chaitanya Telaprolu, Sebastian Polak   +8 more
openaire   +3 more sources

Gabapentin Bioequivalence Study: Quantification By Liquid Chromatography Coupled To Mass Spectrometry [PDF]

, 2015
The study was performed to compare the bioavailability of two gabapentin 400 mg capsule formulation (Gabapentin from Arrow Farmacêutica S/A as test formulation and Neurontin ® from Pfizer, Brazil, as reference formulation) in 26 volunteers of both sexes.
Duarte L.F., Pereira R., Abib Jr. E., Tosetti D., Pozzebon J.M., Custodio J.M.C.   +5 more
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Bioequivalence Evaluation of two formulations of lamotrigine tablets in healthy volunteers

, 2012
: Lamotrigine is a phenyltriazine used in the treatment of epilepsy and bipolar disorder type I. The purpose of this study was to compare the bioavailability in healthy Colombian volunteers of two brands of lamotrigine 100 mg tablets: a new generic ...
Restrepo Garay, Margarita María, Archbold, Rosendo, Montoya Beltrán, Blanca Cecilia, Ruiz Correa, Adriana María, Cuesta González, Fanny, Holguín Martínez, Gloria, Parra, Sergio, Peña Acevedo, Lina   +7 more
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Pharmacokinetic studies for the development of transdermal drug delivery systems [PDF]

, 2007
PhDThis thesis mainly describes a series of Phase I pharmacokinetic studies conducted on the TDS®d elivery systemw hich combinedw ith lidocaine,t estosteronea, nd a new drug, Melanotan-I for the transdermal drug delivery.
Chik, Zamri
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Statistics challenges and opportunities for the twenty first century [PDF]

, 2006
The field of statistics has made remarkable contribution to society over several decades its impact is felt across gradually all branches of science, medicine, industries and planning in the government department.
Bhatt, Viral G.
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¿Cómo se aprende una asignatura en la modalidad Virtual?

, 2015
El vídeo describe la metodología a seguir en cada una de las asignaturas en la modalidad ...
UC Virtual
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