Results 101 to 110 of about 1,942 (154)

Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product [PDF]

, 2018
The quality of a drug product may be characterized by the consistency with which its indicated clinical effect, and safety profile, is experienced by the patient.
Steinbach, Douglas
core   +1 more source

Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. Case example: Naproxen

, 2019
Background: Physiologically-based population pharmacokinetic modeling (popPBPK) coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can serve as a powerful tool to establish virtual bioequivalence and set clinically relevant specifications.
Loisios-Konstantinidis, Ioannis, Cristofoletti, Rodrigo, Fotaki, Nikoletta, Turner, David B., Dressman, Jennifer B.   +4 more
openaire   +1 more source

Point biserial correlation [PDF]

John A. Anderson
core   +4 more sources

In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software. [PDF]

BMC Pharmacol Toxicol, 2023
Wang L, Chen J, Chen W, Ruan Z, Lou H, Yang D, Jiang B.   +6 more
europepmc   +1 more source

Effectiveness of virtual simulation-based pre-learning and the mediating role of metacognition in pharmacokinetics laboratory education. [PDF]

BMC Med Educ
Hu X, Liu J, Wang J.
europepmc   +1 more source

Development of a Universal In Vivo Predictive Dissolution Method for a Borderline BCS III/IV Drug Guided by Modeling and Simulations─Acyclovir as a Case Study. [PDF]

Mol Pharm
García MA, Tapia F, Escares B, Langguth P.   +3 more
europepmc   +1 more source

Computer Simulations as a Tool for Optimizing Bioequivalence Trials [PDF]

, 2012
Alfredo García-Arieta, Carlos Fernández-Teruel, Carmen Navarro-Fontestad, Isabel González-Álvarez, Marival Bermejo, Vicente G. Casabó-Alós, Victor Mangas-Sanjuán   +6 more
core   +1 more source

Physiologically based pharmacokinetic modelling to guide drug delivery in older people [PDF]

, 2018

core   +1 more source

Development of in vitro-in vivo correlation for establishing patient-centric quality standards of dissolution for lamotrigine extended-release tablets. [PDF]

Eur J Pharm Biopharm
Zidan A, Siddique AB, Shaklah M, Anand O, O'Connor T, Ashraf M.   +5 more
europepmc   +1 more source

Mechanistic Modelling of Lidocaine and Prilocaine Absorption from EMLA Cream upon Topical Application using Physiologically Based Pharmacokinetic Modelling. [PDF]

AAPS PharmSciTech
Telaprolu KC, Tsakalozou E, Ghosh P, Alam K, Grice JE, Roberts MS, Jamei M, Polak S, Clarke JF.   +8 more
europepmc   +1 more source