Results 221 to 230 of about 12,263,359 (280)

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Cross-fusion of digital twins and artificial intelligence in diabetes: from mechanistic elucidation to full-cycle precision management. [PDF]

Front Endocrinol (Lausanne)
Sun Y, Yang R, Xin Q, Luo X, Zhou Y, Fu Z, Li J, Gu Z, Liu J, Wang Q, Yang Y.   +10 more
europepmc   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

A Comprehensive Method to Evaluate the Usability of Virtual Reality Headset Devices for Industrial Applications. [PDF]

Sensors (Basel)
Cirelli M, Cellupica A, Valentini PP, Cinque L, Marini MR.   +4 more
europepmc   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

UAV aerial image-based apparent defect detection method for embankments using an integrated framework of improved YOLOv8 and SAHI. [PDF]

Sci Rep
Yuan D, Qiu C, Wei B, Li J.
europepmc   +1 more source

Comparing Judgments of Relative Direction and Object-Based Judgments as Measures of Human Spatial Memory: Evaluation with a Measurement Model. [PDF]

Q J Exp Psychol (Hove)
Colle HA, Carpenter Z, Molinar TJ.
europepmc   +1 more source

Mapping the complexity of psychomotor skills in core nursing procedures: A content analysis for simulation-based education. [PDF]

Int J Nurs Stud Adv
Kim H, Koh A, Lee S, Jin S, Hyun MH, Shin H.   +5 more
europepmc   +1 more source