Results 121 to 130 of about 59,693 (314)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

open access: yesAdvanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang   +8 more
wiley   +1 more source

Academic digital libraries of the future : an environment scan

open access: yes, 2009
Libraries are attempting to face a future in which almost every fixed point has disappeared. Users are changing; content is changing; research is taking new forms. Indeed the very need for libraries is being questioned in some quarters.
Law, Derek
core   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

open access: yesAdvanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo   +6 more
wiley   +1 more source

Assessing Chat Transcripts

open access: yesInternational Journal of Librarianship
Ask Us is the Southern Methodist University (SMU) Libraries chat reference service. Since Ask Us is most people’s introduction to SMU Libraries, it’s essential the experience is positive.
Rebecca Graff   +2 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

open access: yesAdvanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan   +10 more
wiley   +1 more source

Virtual Reality: Is It Real Or Not?

open access: yesTürk Kütüphaneciliği, 1996
In this paper virtual reality technology and how libraries might be affected by this technology are examined. Virtual reality sets out to address a problem. The problem is that of user-friendliness of computer systems.
S. Serap Kurbanoğlu
doaj  

Leo Kim Virtual Program, April 22, 2021

open access: yes, 2021
This was a virtual event held live on Zoom, hosted by NDSU Libraries with support from the NDSU Department of Communication.A virtual program was held to celebrate the life and work of distinguished photographer and former NDSU student Leo Kim.

core  

Machine‐Learning Framework for Designing Stable Interfaces in All‐Solid‐State Lithium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
A data‐driven strategy is developed to discover coating materials for all‐solid‐state lithium batteries. Using calculations of interfacial reactivity, unsupervised pattern recognition, and machine‐learning prediction, the study identifies low‐reactivity compositional patterns and screens new lithium‐based oxide and polyanion candidates, extending ...
Sehyeok Park   +4 more
wiley   +1 more source

Virtual Libraries during the COVID-19 Pandemic [PDF]

open access: yesProceeding Papers (BASIQ International Conference), 2021
Daniela Baiasu, Răzvan-Ion Chitescu
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

open access: yesAdvanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen   +11 more
wiley   +1 more source

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