Results 101 to 110 of about 59,693 (314)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

How Much is Much?: a Conceptual Study of Web Traffic

Liber Quarterly: The Journal of European Research Libraries, 2012
Valid and relevant statistics are required for library planning and advocacy. As libraries and their users turn to the web, library statistics must follow.
Tord Høivik
doaj   +1 more source

Virtual Advice Services

, 2011
The chapter looks at the issues involved with implementing and running a chat enquiry service, from choosing an appropriate product to staff training and publicity.
Geeson, R.
core  

Do we remove all the walls? Second Life librarianship

, 2008
More than five hundred librarians have been experimenting with providing library services within Second Life, a Multi User Virtual Environment (MUVE) with over thirty thousand users online at any time. This paper outlines the advantages for librarians of
Kathryn Greenhill, Greenhill, K., Greenhill, Kathryn   +2 more
core   +1 more source

Common principles in managing digital libraries and managing VLEs [PDF]

, 2006
This paper illustrate how there are common ways of managing both digital libraries and VLEs (virtual learning environments), based on the concept-in-common of a devolved or centralised approach to their implementation and a devolved or centralised long ...
Joint, N.
core   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Perpustakaan maya sebagai sumber belajar dan penunjang pembelajaran IPS secara daring di era pandemi COVID-19

Jurnal Teori dan Praksis Pembelajaran IPS, 2020
This article aimed to describe how important the existence of virtual libraries is as a learning resource in online social studies learning, because virtual libraries provide the widest possible access by anyone, anywhere, anytime to dig up various ...
Mochamad Doni Akviansah, Sariyatun Sariyatun   +1 more
doaj  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Gestión e implementación de herramientas y servicios bibliotecarios virtuales en la Web 2.0 [PDF]

, 2007
On the relevance of the new Web 2.0 virtual information technology tools, such as content management systems (CMS), digital libraries, podcasting, blogs and other applications, and how these can be utilized as new virtual information services in order to
Gonzáles Cam, Celso
core  

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source