Results 91 to 100 of about 723,786 (352)
Advanced Science, EarlyView.FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang +14 more
wiley +1 more source
Cryptosporidium Pathogenicity and Virulence [PDF]
Clinical Microbiology Reviews, 2013 SUMMARYCryptosporidiumis a protozoan parasite of medical and veterinary importance that causes gastroenteritis in a variety of vertebrate hosts. Several studies have reported different degrees of pathogenicity and virulence amongCryptosporidiumspecies and isolates of the same species as well as evidence of variation in host susceptibility to infection.
Bouzid, Maha +3 more
openaire +4 more sources
Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives
Advanced Science, EarlyView.Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu +13 more
wiley +1 more source
Microbial Virulence Factors [PDF]
International Journal of Molecular Sciences, 2020 Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease [...]
openaire +3 more sources
Advanced Science, EarlyView.The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei +7 more
wiley +1 more source
Microbiome, 2023 Background Ticks are major vectors of diseases affecting humans such as Lyme disease or domestic animals such as anaplasmosis. Cross-alteration of the vertebrate host skin microbiome and the tick microbiome may be essential during the process of tick ...
Nathalie Boulanger +9 more
doaj +1 more source
Advanced Science, EarlyView.This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen +8 more
wiley +1 more source
Evolution of malaria virulence in cross-generation transmission through selective immune pressure [PDF]
, 2007 Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence.
David E. Gurarie
core +2 more sources
Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]
, 2017 The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.
Brown, Alistair J P +4 more
core +2 more sources
Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings
Advanced Science, EarlyView.N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang +15 more
wiley +1 more source