Results 61 to 70 of about 532,349 (305)

Virulence and Metabolism

Microbiology Spectrum, 2019
ABSTRACT Staphylococcus aureus is clearly the most pathogenic member of the Staphylococcaceae . This is in large part due to the acquisition of an impressive arsenal of virulence factors that are coordinately regulated by a series of dedicated transcription factors.
openaire   +2 more sources

Evolution of malaria virulence in cross-generation transmission through selective immune pressure [PDF]

, 2007
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence.
David E. Gurarie
core  

Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus [PDF]

, 2015
Date of Acceptance: 20/07/2015Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and
Williams, Barnabas, Uhlemann, Anne-Catrin, Edward Feil, Recker, Mario, Maisem Laabei (311431), Lowy, FD, Clarke, SR, Janina Dordel (250569), Janina Dordel, Votintseva, Antonina A., Lowy, Franklin D., Votintseva, AA, Austin, ED, Wilson, Daniel J, Bowden, Rory, Wilson, Daniel J., Daniel J. Wilson (194149), Matthew Holden, Crook, Derrick W., Dordel, Janina, Derrick W Crook, Maho Yokoyama (791513), Thorpe, Harry A, Holden, Matthew, Matthew Holden (791517), Sharon J. Peacock (35782), Derrick W. Crook (145636), Austin, Eloise D, Williams, B, Mario Recker (88496), Sharon J Peacock, Eloise D Austin, Perkins, Mark, Votintseva, Antonina A, Barnabas Williams (791515), Recker, M, Mario Recker, Franklin D Lowy, Young, Bernadette C, Khadija Ouadi, Ouadi, Khadija, Eloise D. Austin (791512), Rory Bowden (179995), Crook, Derrick, Wilson, DJ, Barnabas Williams, Bernadette C Young, Maho Yokoyama, Yokoyama, Maho, Clark, Stephen Robert, Harry A Thorpe, Franklin D. Lowy (299074), Uhlemann, AC, Feil, E, Edward Feil (270047), Anne-Catrin Uhlemann, Stephen R Clarke, Ouadi, K, Antonina A Votintseva, Clarke, Stephen R, Peacock, Sharon J., Mark Perkins, Peacock, SJ, Laabei, M, Ruth C. Massey (174217), Maisem Laabei, Antonina A. Votintseva (791518), Harry A. Thorpe (791514), Austin, Eloise D., Young, BC, Peacock, Sharon J, Massey, Ruth C., Mark Perkins (254177), Bernadette C. Young (408943), Massey, RC, Crook, DW, Thorpe, HA, Clarke, Stephen R., Feil, Edward, Anne-Catrin Uhlemann (299063), Wilson, Daniel, Crook, Derrick W, Laabei, Maisem, Khadija Ouadi (598087), Perkins, M, Lowy, Franklin D, Daniel J Wilson, Rory Bowden, Stephen R. Clarke (791516), Bowden, R, Dordel, J, Massey, Ruth C, Young, Bernadette C., Thorpe, Harry A., Yokoyama, M, Holden, M, Ruth C Massey   +96 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associated Staphylococcus aureus in France

Microbiology Spectrum
In Staphylococcus aureus, an animal pathogen and zoonotic agent, plasmids play a pivotal role in the acquisition and spread of antibiotic resistance genes (ARGs). This study investigated the plasmid content of 329 S.
Rachel Contarin, Séverine Murri, Antoine Drapeau, Tom Cayssials, Jean-Yves Madec, Emilie Dordet-Frisoni, Marisa Haenni   +6 more
doaj   +1 more source

Pathogenic Escherichia coli in Dogs Reveals the Predominance of ST372 and the Human-Associated ST73 Extra-Intestinal Lineages

Frontiers in Microbiology, 2020
Escherichia coli is a ubiquitous commensal and pathogen that has also been recognized as a multi-sectoral indicator of antimicrobial resistance (AMR).
Charlotte Valat, Antoine Drapeau, Stéphanie Beurlet, Véronique Bachy, Henri-Jean Boulouis, Raphaëlle Pin, Géraldine Cazeau, Jean-Yves Madec, Marisa Haenni   +8 more
doaj   +1 more source

Evolution of virulence

Infectious Disease Clinics of North America, 2004
At the close of the 19th century, the germ theory had generated a new understanding of the causes of acute infectious diseases and revealed new directions for study. This understanding contributed to the greatest improvements in health in the history of medicine.
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Clonal, Plasmidic and Genetic Diversity of Multi-Drug-Resistant Enterobacterales from Hospitalized Patients in Tripoli, Libya

Antibiotics, 2023
Resistance to extended-spectrum cephalosporins (ESC) and carbapenems in Enterobacterales is a major issue in public health. Carbapenem resistance in particular is associated with increased morbidity and mortality.
Nada Elgriw, Véronique Métayer, Antoine Drapeau, Pauline François, Sana Azaiez, Maha Mastouri, Hajer Rhim, Adam Elzagheid, Najeeb Soufiyah, Jean-Yves Madec, Cherifa Chaouch, Wejdene Mansour, Marisa Haenni   +12 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source