Results 101 to 110 of about 4,443,372 (306)
Novel insights into the epigenetic regulation of Plasmodium falciparum virulence genes [PDF]
, 2013 Plasmodium falciparum malaria still places a major health burden upon the developing world. The high virulence of this parasite is linked to the variegated expression of single P.
Brancucci, Nicolas Michel Beat
core +1 more source
Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila
Advanced Science, EarlyView.While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li +7 more
wiley +1 more source
Frontiers in Plant Science, 2015 Canker caused by the Ascomycete Valsa mali is the most destructive disease of apple in Eastern Asia, resulting in yield losses of up to 100 %. This necrotrophic fungus induces severe necrosis on apple, eventually leading to the death of the whole tree ...
Zhengpeng eLi +5 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Potentially virulence-related extracellular proteins of Streptococcus equi [PDF]
, 2006 Equine strangles, a disease of the upper respiratory tract caused by the bacterium Streptococcus equi subspecies equi, is one of the most commonly diagnosed and serious diseases in horses. However, the molecular basis of S. equi subsp.
Lannergård, Jonas
core +1 more source
Evolution of malaria virulence in cross-generation transmission through selective immune pressure [PDF]
, 2007 Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence.
David E. Gurarie
core
Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]
, 2013 Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid, Vale, Pedro F.
core +1 more source
Advanced Science, EarlyView.A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang +12 more
wiley +1 more source
When is a bacterial “virulence factor” really virulent? [PDF]
, 2016 ABSTRACT Bacterial traits that contribute to disease are termed ‘virulence factors’ and there is much interest in therapeutic approaches that disrupt such traits. However, ecological theory predicts disease severity to be multifactorial and context dependent, which might complicate our efforts to identify the most ...
Granato, Elisa T. +3 more
openaire +1 more source
Advanced Science, EarlyView.PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong +14 more
wiley +1 more source